A sensitive method for digoxin determination using formate-adduct ion based on the effect of ionization enhancement in liquid chromatograph-mass spectrometer

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 978-979, Issue , 2015, Pages 138-144

  Li, Xia ^a   Wang, Yu ^a   Zhou, Qingyuan ^a   Yu, Yunqiu ^a   Chen, Lihong ^b   Zheng, Jie ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Digoxin; Formate adduct; LC MS MS; Rat plasma; Sensitivity

Indexed keywords

BODY FLUIDS; FORMIC ACID; IONIZATION OF LIQUIDS; METABOLITES; RATS;

DIGOXIN; FORMATE-ADDUCT; LC/MS/MS; RAT PLASMA; SENSITIVITY;

IONS;

DESLANOSIDE; DIGITOXIN; DIGOXIN; FORMIC ACID; GINSENOSIDE RB 1; GINSENOSIDE RG 1; FORMIC ACID DERIVATIVE;

ADDUCTION; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; HUMAN; IONIZATION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; RAT; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; VALIDATION STUDY; ANIMAL; BLOOD; CHEMISTRY; DRUG STABILITY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; TANDEM MASS SPECTROMETRY;

RATTUS;

ANIMALS; CHROMATOGRAPHY, LIQUID; DIGOXIN; DRUG STABILITY; FORMATES; HUMANS; LINEAR MODELS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84919833629     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.11.023     Document Type: Article

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