Development of a quantification method for digoxin, a typical P-glycoprotein probe in clinical and non-clinical studies, using high performance liquid chromatography-tandem mass spectrometry: The usefulness of negative ionization mode to avoid competitive adduct-ion formation

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 32, 2011, Pages 3837-3844

  Hirabayashi, Hideki ^a   Sugimoto, Hiroshi ^a   Matsumoto, Shinichi ^a   Amano, Nobuyuki ^a   Moriwaki, Toshiya ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Adduct formation; Analytical method; Digoxin; P glycoprotein; Tandem mass spectrometry

Indexed keywords

ADDUCT FORMATION; ANALYTICAL METHOD; DIGOXIN; P-GLYCOPROTEIN; TANDEM MASS SPECTROMETRY;

ACETONITRILE; AMMONIUM COMPOUNDS; CHROMATOGRAPHY; DEUTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETRY; METHANOL; PROBES; RAT CONTROL; RATS; SODIUM CHLORIDE;

GLYCOPROTEINS;

ACETONITRILE; AMMONIUM CARBONATE; DEUTERIUM; DIGOXIN; GLYCOPROTEIN P; METHANOL; SODIUM CHLORIDE; SODIUM HYDROXIDE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG LABELING; DRUG SCREENING; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IONIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIGOXIN; DRUG STABILITY; LIMIT OF DETECTION; LINEAR MODELS; LIQUID-LIQUID EXTRACTION; MALE; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 82955227505     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.10.031     Document Type: Article

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