What can we expect from biomarkers for acute kidney injury?

Biomarkers in Medicine

Volumn 8, Issue 10, 2014, Pages 1239-1245

  Kellum, John A ^a   Devarajan, Prasad ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

acute kidney injury; acute renal failure; biomarkers; clinical trial design; diagnostics; risk assessment

Indexed keywords

BIOLOGICAL MARKER; CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 7; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; CHRONIC KIDNEY DISEASE; CLINICAL DECISION MAKING; CLINICAL TRIAL (TOPIC); CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; GLOMERULUS FILTRATION RATE; HUMAN; OLIGURIA; REVIEW; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; URINE VOLUME; ACUTE KIDNEY INJURY; BLOOD; URINE;

ACUTE KIDNEY INJURY; BIOMARKERS; CLINICAL TRIALS AS TOPIC; HUMANS;

EID: 84919796420     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/bmm.14.82     Document Type: Review

References (24)

1. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup. Acute renal failure: definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Clin. Care 8(4), R204-R212 (2004
2. Mehta RL, Kellum JA, Shah SV., et al Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. 11(2), R31 (2007
3. KDIGO AKI Workgroup. Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline for acute kidney injury. Kidney Int. Suppl. 2012 2, 1-141 (2012
4. Bell M, Granath F, Mårtensson J., et al. Cystatin C is correlated with mortality in patients with and without acute kidney injury. Nephrol. Dial. Transplant. 24(10), 3096-3102 (2009
5. Mehta RL, Pascual MT, Gruta CG, Zhuang S, Chertow GM. Refining predictive models in critically ill patients with acute renal failure. J. Am. Soc. Nephrol. 13(5), 1350-1357 (2002
6. Palevsky PM, Liu KD, Brophy PD., et al. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am. J. Kidney Dis. 61(5), 649-672 (2013
7. The Ad-Hoc Working Group of ERBP; Fliser D, Laville M., et al. A European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guidelines on Acute Kidney Injury: Part 1: Definitions, conservative management and contrast-induced nephropathy. Nephrol. Dial. Transplant. 27(12), 4263-4272 (2012
8. Ralib AM, Pickering JW, Shaw GM, Endre ZH. The urine output definition of acute kidney injury is too liberal. Crit. Care 17(3), R112 (2013
9. Zeng X, McMahon GM, Brunelli SM, Bates DW, Waikar SS. Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin. J. Am. Soc. Nephrol. 9(1), 12-20 (2014
10. Levey AS, Coresh J, Balk E., et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann. Intern. Med. 139(2), 137-147 (2003
11. Goldstein SL, Jaber BL, Faubel S, Chawla LS, Acute Kidney Injury Advisory Group of American Society of Nephrology. AKI transition of care: a potential opportunity to detect and prevent CKD. Clin. J. Am. Soc. Nephrol. 8(3), 476-483 (2013
12. Goldstein SL, Chawla L, Ronco C, Kellum JA. Renal recovery. Crit Care. 18(1), 301 (2014
13. Murugan R, Karajala-Subramanyam V, Lee M., et al. Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int. 77(6), 527-535 (2010
14. Kashani K, Al-Khafaji A, Ardiles T., et al. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit. Care 17(1), R25 (2013
15. Kerr KF, Meisner A, Thiessen-Philbrook H, Coca SG, Parikh CR. Developing risk prediction models for kidney injury and assessing incremental value for novel biomarkers. Clin. J. Am. Soc. Nephrol. 9(8), 1488-1496 (2014
16. Endre ZH, Pickering JW, Walker RJ., et al. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int. 79(10), 1119-1130 (2011
17. Nickolas TL, Schmidt-Ott KM, Canetta P., et al. Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: A multicenter prospective cohort study. J. Am. Coll. Cardiol. 59(3), 246-255 (2012
18. Nickolas TL, O'Rourke MJ, Yang J., et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann. Intern. Med. 148(11), 810-819 (2008
19. Haase-Fielitz A, Haase M, Devarajan P. Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status. Ann. Clin. Biochem. 51(3), 335-351 (2014
20. Bihorac A, Chawla LS, Shaw AD., et al. Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am. J. Respir. Crit. Care Med. 189(8), 932-939 (2014
21. Price PM, Safirstein RL, Megyesi J. The cell cycle and acute kidney injury. Kidney Int. 76(6), 604-613 (2009
22. Boonstra J, Post JA. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 337, 1-13 (2004
23. Seo D-W, Li H, Qu C-K., et al. Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells. J. Biol. Chem. 281(6), 3711-3721 (2006
24. Zuo S, Liu C, Wang J., et al. IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells. J. Cancer Res. Clin. Oncol. 138(6), 1045-1055 (2012