Prion diseases and adult neurogenesis: How do prions counteract the brain's endogenous repair machinery?

Prion

Volumn 8, Issue 3, 2014, Pages 240-246

  Relaño Ginés, Aroa ^a,c   Lehmann, Sylvain ^a,b   Crozet, Carole ^a,b  

^a INSTITUTE OF HUMAN GENETICS   (France)

^b INSERM   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell therapy; Neurodegenerative diseases; Neurogenesis; Prion; Stem cell

Indexed keywords

ADULT; ANIMAL CELL; ARTICLE; CELL FATE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRION; PRION DISEASE; PROTEIN AGGREGATION; STEM CELL TRANSPLANTATION; ANIMAL; BRAIN; CELL GROWTH; CELL LINE; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; STEM CELL;

MUS;

PRION;

ANIMALS; BRAIN; CELL GROWTH PROCESSES; CELL LINE; MICE; NEUROGENESIS; PRION DISEASES; PRIONS; STEM CELLS;

EID: 84919777737     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.29021     Document Type: Article

References (30)

1. Collinge J. Prion diseases of humans and animals: their causes and molecular basis. Annu Rev Neurosci 2001; 24:519-50; PMID:11283320; http://dx.doi.org/10.1146/annurev.neuro.24.1.519
2. Prusiner SB, Scott MR, DeArmond SJ, Cohen FE Prion protein biology. Cell 1998; 93:337-48; PMID:9590169; http://dx.doi.org/10.1016/S0092-8674(00)81163-0
3. Bouzamondo-Bernstein E., Hopkins SD, Spilman P, Uyehara-Lock J, Deering C., Safar J, Prusiner SB, Ralrdston HJ 3, DeArmond SJ. The neurodegeneration sequence in prion diseases: evidence from functional, morphological and ultrastructural studies of the GABAergic system. J Neuropathol Exp Neurol 2004; 63:882-99; PMID:15330342
4. Mallucci G, Collinge J. Rational targeting for prion therapeutics. Nat Rev Neurosci 2005; 6:23-34; PMID:15611724; http://dx.doi.org/10.1038/nrn1584
5. Brown KL, Brown J, Ritchie DL, Sales J., Fraser JR Fetal cell grafts provide long-term protection against scrapie induced neuronal loss. Neuroreport 2001; 12:77-82; PMID:11201096; http://dx.doi.org/10.1097/00001756-200101220-00023
6. Relano-Gines A., Lehmann S, Bencsik A., Herva ME, Torres JM, Crozet CA Stem cell therapy extends incubation and survival time in prion-infected mice in a time window-dependant manner. J Infect Dis 2011; 204:1038-45; PMID:21881119; http://dx.doi.org/10.1093/infdis/jir484
7. Relano-Gines A., Gabelle A, Lehmann S., Milhavet O, Crozet C. Gene and cell therapy for prion diseases. Infect Disord Drug Targets 2009; 9:58-68; PMID: 19200016; http://dx.doi.org/10.2174/1871526510909010058
8. Crozet C, Lin YL, Mettling C, Mourton-Gilles C, Corbeau P., Lehmann S, Perrier V. Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations. J Cell Sci 2004; 117:5591-7; PMID:15494372; http://dx.doi.org/10.1242/jcs.01484
9. Toupet K, Compan V, Crozet C., Mourton-Gilles C, Mestre-Frances N, Ibos F., Corbeau P, Verdier JM, Perrier V. Effective gene therapy in a mouse model of prion diseases. PLoS One 2008; 3:e2773; PMID:18648643; http://dx.doi.org/10.1371/journal.pone.0002773
10. Cameron HA, McKay RD Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 2001; 435:406-17; PMID:11406822; http://dx.doi.org/10.1002/cne.1040
11. Taupin P, Gage FH Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res 2002; 69:745-9; PMID:12205667; http://dx.doi.org/10.1002/jnr.10378
12. Alvarez-Buylla A., Garcia-Verdugo JM. Neurogenesis in adult subventricular zone. J Neurosci 2002; 22:629-34; PMID:11826091
13. Gage FH. Mammalian neural stem cells. Science 2000; 287:1433-8; PMID:10688783; http://dx.doi.org/10.1126/science.287.5457.1433
14. Kempermann G, Wiskott L, Gage FH Functional significance of adult neurogenesis. Curr Opin Neurobiol 2004; 14:186-91; PMID:15082323; http://dx.doi.org/10.1016/j.conb.2004.03.001
15. Ruan L, Lau BW, Wang J, Huang L., Zhuge Q, Wang B, et al Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside. Prog Neurobiol 2014; 115:116-37; PMID:24384539
16. Cayre M, Canoll P, Goldman JE Cell migration in the normal and pathological postnatal mammalian brain. Prog Neurobiol 2009; 88:41-63; PMID:19428961; http://dx.doi.org/10.1016/j.pneurobio.2009.02.001
17. Arvidsson A, Collin T, Kirik D., Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002; 8:963-70; PMID:12161747; http://dx.doi.org/10.1038/nm747
18. Jin K, Sun Y, Xie L., Peel A, Mao XO, Batteur S, Greenberg DA Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol Cell Neurosci 2003; 24:171-89; PMID:14550778; http://dx.doi.org/10.1016/S1044-7431(03)00159-3
19. Jin K, Peel AL, Mao XO, Xie L., Cottrell BA, Henshall DC, Greenberg DA Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci U S A 2004; 101:343-7; PMID:14660786; http://dx.doi.org/10.1073/pnas.2634794100
20. Curtis MA, Penney EB, Pearson AG, van Roon-Mom WM, Butterworth NJ, Dragunow M, Connor B, Faull RL. Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain. Proc Natl Acad Sci U S A 2003; 100:9023-7; PMID:12853570; http://dx.doi.org/10.1073/pnas.1532244100
21. Chevallier NL, Soriano S, Kang DE, Masliah E., Hu G, Koo EH Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol 2005; 167:151-9; PMID:15972961; http://dx.doi.org/10.1016/S0002-9440(10)62962-8
22. Mehler MF, Gokhan S. Developmental mechanisms in the pathogenesis of neurodegenerative diseases. Prog Neurobiol 2001; 63:337-63; PMID:11115729; http://dx.doi.org/10.1016/S0301-0082(00)00052-6
23. Cronier S, Carimalo J, Schaeffer B., Jaumain E, Beringue V, Miquel MC, Laude H., Peyrin JM Endogenous prion protein conversion is required for prion-induced neuritic alterations and neuronal death. FASEB J 2012; 26:3854-61; PMID:22661006; http://dx.doi.org/10.1096/fj.11-201772
24. Steele AD, Emsley JG, Ozdinler PH, Lindquist S., Macklis JD Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci USA 2006; 103:3416-21; PMID:16492732; http://dx.doi.org/10.1073/pnas.0511290103
25. Westergard L, Christensen HM, Harris DA The cellular prion protein (PrP(C)): its physiological function and role in disease. Biochim Biophys Acta 2007; 1772:629-44; PMID:17451912; http://dx.doi.org/10.1016/j.bbadis.2007.02.011
26. Pradines E, Hernandez-Rapp J, Villa-Diaz A, Dakowski C, Ardila-Osorio H, Haik S., Schneider B, Launay JM, Kellermann O, Torres JM, et al. Pathogenic prions deviate PrP(C) signaling in neuronal cells and impair A-beta clearance. Cell Death Dis 2013; 4:e456; PMID:23303130; http://dx.doi.org/10.1038/cddis.2012.195
27. Simon D, Herva ME, Benitez MJ, Garrido JJ, Rojo AI, Cuadrado A, et al Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease. Neuropathol Appl Neurobiol 2014; 40:311-26; PMID:23741998
28. Relano-Gines A., Gabelle A, Hamela C., Belondrade M, Casanova D, Mourton-Gilles C, Lehmann S., Crozet C. Prion replication occurs in endogenous adult neural stem cells and alters their neuronal fate: involvement of endogenous neural stem cells in prion diseases. PLoS Pathog 2013; 9:e1003485; PMID:23935493; http://dx.doi.org/10.1371/journal.ppat.1003485
29. Haughey NJ, Nath A, Chan SL, Borchard AC, Rao MS, Mattson MP Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem 2002; 83:1509-24; PMID:12472904; http://dx.doi.org/10.1046/j.1471-4159.2002.01267.x
30. Lee YJ, Baskakov IV The cellular form of the prion protein is involved in controlling cell cycle dynamics, self-renewal, and the fate of human embryonic stem cell differentiation. J Neurochem 2013; 124:310-22; PMID:22860629; http://dx.doi.org/10.1111/j.1471-4159.2012.07913.x