The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation

Gut

Volumn 64, Issue 1, 2015, Pages 11-19

  Barbera, Mariagnese ^a   Pietro, Massimiliano D ^a   Walker, Elaine ^a   Brierley, Charlotte ^a   MacRae, Shona ^a   Simons, Benjamin D ^b,c,d   Jones, Phil H ^a   Stingl, John ^d   Fitzgerald, Rebecca C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CD34 ANTIGEN; CYTOKERATIN; CYTOKERATIN 13; EPITHELIAL CELL ADHESION MOLECULE; KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 2; PANCYTOKERATIN; PROTEIN P63; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CELL SELF RENEWAL; COLONY FORMATION; CONTROLLED STUDY; ESOPHAGUS MUCOSA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MITOSIS RATE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; SQUAMOUS EPITHELIUM; SQUAMOUS EPITHELIUM CELL; THREE DIMENSIONAL IMAGING; CELL CLONE; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; ESOPHAGUS; MITOSIS; PHYSIOLOGY;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; EPITHELIAL CELLS; ESOPHAGUS; HUMANS; MITOSIS;

EID: 84919762825     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-306171     Document Type: Article

References (24)

1. Blanpain C, Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 2009; 10: 207-17.
2. Lagergren J, Bergstrom R, Lindgren A, et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825-31.
3. Goetsch E. The structure of the mammalian esophagus. Am J Anat 1910; 10: 1-40.
4. Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008; 132: 598-611.
5. Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449: 1003-7.
6. Barker N, Ridgway RA, van Es JH, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009; 457: 608-11.
7. Croagh D, Phillips WA, Redvers R, et al. Identification of candidate murine esophageal stem cells using a combination of cell kinetic studies and cell surface markers. Stem Cells 2007; 25: 313-18.
8. Kalabis J, Oyama K, Okawa T, et al. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest 2008; 118: 3860-9.
9. Doupe DP, Alcolea MP, Roshan A, et al. A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science 2012; 337: 1091-3.
10. Grinnell F. Wound repair, keratinocyte activation and integrin modulation. J Cell Sci 1992; 101(Pt 1): 1-5.
11. Jankowski J, Austin W, Howat K, et al. Proliferating cell nuclear antigen in oesophageal mucosa: comparison with autoradiography. Eur J Gatroenetrol Hepathol 1992; 4: 579-84.
12. Seery JP, Watt FM. Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium. Curr Biol 2000; 10: 1447-50.
13. Pan Q, Nicholson AM, Barr H, et al. Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus. Gastroenterology 2013; 144: 761-70.
14. Saadi A, Shannon NB, Lao-Sirieix P, et al. Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers. Proc Natl Acad Sci USA 2010; 107: 2177-82.
15. Rader JS, Golub TR, Hudson JB, et al. In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions. Oncogene 1990; 5: 571-6.
16. Jones PH, Harper S, Watt FM. Stem cell patterning and fate in human epidermis. Cell 1995; 80: 83-93.
17. Legg J, Jensen UB, Broad S, et al. Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Development 2003; 130: 6049-63.
18. Seery JP Stem cells of the oesophageal epithelium. J Cell Sci 2002; 115: 1783-9.
19. Smart IH Changes in location and orientation of mitotic figures in mouse oesophageal epithelium during the development of stratification. J Anat 1970; 106: 15-21.
20. Jones PH, Watt FM. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 1993; 73: 713-24.
21. Leedham SJ, Preston SL, McDonald SA, et al. Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus. Gut 2008; 57: 1041-8.
22. Chang CL, Lao-Sirieix P, Save V, et al. Retinoic acid-induced glandular differentiation of the oesophagus. Gut 2007; 56: 906-17.
23. Quante M, Bhagat G, Abrams JA, et al. Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell 2012; 21: 36-51.
24. Wang X, Ouyang H, Yamamoto Y, et al. Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell 2011; 145: 1023-35.