Simvastatin is associated with reduced risk of acute pancreatitis: Findings from a regional integrated healthcare system

Gut

Volumn 64, Issue 1, 2015, Pages 133-138

  Wu, Bechien U ^a   Pandol, Stephen J ^b   Liu, In Lu Amy ^c  

^a KAISER PERMANENTE   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c Department of Research and Evaluation Kaiser Permanente Southern California ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACUTE PANCREATITIS; ADULT; AGE; AGED; ALCOHOLISM; ARTICLE; CHOLELITHIASIS; CONTROLLED STUDY; DISEASE COURSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EXPOSURE; DRUG USE; ETHNIC DIFFERENCE; FEMALE; FOLLOW UP; HIGH RISK POPULATION; HUMAN; HYPERTRIGLYCERIDEMIA; INCIDENCE; INTEGRATED HEALTH CARE SYSTEM; MAJOR CLINICAL STUDY; MALE; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SEX DIFFERENCE; SMOKING; TREATMENT DURATION; UNITED STATES; ACUTE DISEASE; ADOLESCENT; CHEMICALLY INDUCED; COHORT ANALYSIS; MIDDLE AGED; PANCREATITIS; YOUNG ADULT;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; COHORT STUDIES; DELIVERY OF HEALTH CARE, INTEGRATED; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PANCREATITIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SIMVASTATIN; YOUNG ADULT;

EID: 84919726677     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-306564     Document Type: Article

References (16)

1. Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 2012; 143: 1179-87. e1-3.
2. National Center for Health Statistics. Health US, 2010: in brief. Center for Disease Control and Prevention Hyattsville, MD. 2011.
3. Anagnostopoulos GK, Tsiakos S, Margantinis G, et al. Acute pancreatitis due to pravastatin therapy. Jop 2003; 4: 129-32.
4. Pezzilli R, Ceciliato R, Corinaldesi R, et al. Acute pancreatitis due to simvastatin therapy: increased severity after rechallenge. Dig Liver Dis 2004; 36: 639-40.
5. McDonald KB, Garber BG, Perreault MM. Pancreatitis associated with simvastatin plus fenofibrate. Ann Pharmacother 2002; 36: 275-9.
6. Singh S, Nautiyal A, Dolan JG. Recurrent acute pancreatitis possibly induced by atorvastatin and rosuvastatin. Is statin induced pancreatitis a class effect? Jop 2004; 5: 502-4.
7. Preiss D, Tikkanen MJ, Welsh P, et al. Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA 2012; 308: 804-11.
8. Gornik I, Gasparovic V, Gubarev Vrdoljak N, et al. Prior statin therapy is associated with milder course and better outcome in acute pancreatitis - a cohort study. Pancreatology 2013; 13: 196-200.
9. von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med 2007; 4:e296.
10. Yadav D, Agarwal N, Pitchumoni CS. A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol 2002; 97: 1309-18.
11. Badalov N, Baradarian R, Iswara K, et al. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol 2007; 5: 648-61; quiz 4.
12. Thisted H, Jacobsen J, Munk EM, et al. Statins and the risk of acute pancreatitis: a population-based case-control study. Aliment Pharmacol Ther 2006; 23: 185-90.
13. Saligram S, Lo D, Saul M, et al. Analyses of hospital administrative data that use diagnosis codes overestimate the cases of acute pancreatitis. Clin Gastroenterol Hepatol 2012; 10: 805-11 e1.
14. Bu DX, Griffin G, Lichtman AH. Mechanisms for the anti-inflammatory effects of statins. Curr Opin Lipidol 2011; 22: 165-70.
15. Jougasaki M, Ichiki T, Takenoshita Y, et al. Statins suppress interleukin-6-induced monocyte chemo-attractant protein-1 by inhibiting Janus kinase/signal transducers and activators of transcription pathways in human vascular endothelial cells. Br J Pharmacol 2010; 159: 1294-303.
16. Morck C, Olsen L, Kurth C, et al. Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans. Proc Natl Acad Sci USA 2009; 106: 18285-90.