Reply to comment on "an antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice"

Science Translational Medicine

Volumn 6, Issue 268, 2014, Pages

  Sheline, Yvette I ^a   West, Tim ^b   Yarasheski, Kevin ^c   Jasielec, Mateusz S ^d   Hettinger, Jane C ^c   Tripoli, Danielle L ^c   Xiong, Chengjie ^c,d   Frederiksen, Christine ^c   Grzelak, Monica V ^c   Bateman, Randall J ^c   Morris, John C ^c   Lee, Jin Moo ^c   Cirrito, John R ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b C2N Diagnostics   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CITALOPRAM; ESCITALOPRAM; ANTIDEPRESSANT AGENT;

ALZHEIMER DISEASE; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; HUMAN; LETTER; MOUSE; NONHUMAN; PROTEIN CEREBROSPINAL FLUID LEVEL; SINGLE DRUG DOSE; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; CEREBROSPINAL FLUID; CHEMISTRY; FEMALE; GENETICS; MALE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIDEPRESSIVE AGENTS; CITALOPRAM; FEMALE; HUMANS; MALE;

EID: 84919719373     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3010609     Document Type: Letter

References (6)

1. J. F. Emilsson, U. Andreasson, K. Blennow, E. Eriksson, H. Zetterberg, Comment on "An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice." Sci. Transl. Med. 6, 268le5 (2014).
2. Y. I. Sheline, T. West, K. Yarasheski, R. Swarm, M. S. Jasielec, J. R. Fisher, W. D. Ficker, P. Yan, C. Xiong, C. Frederiksen, M. V. Grzelak, R. Chott, R. J. Bateman, J. C. Morris, M. A. Mintun, J. M. Lee, J. R. Cirrito, An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice. Sci. Transl. Med. 6, 236re4 (2014).
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6. J. R. Cirrito, B. M. Disabato, J. L. Restivo, D. K. Verges, W. D. Goebel, A. Sathyan, D. Hayreh, G. D'Angelo, T. Benzinger, H. Yoon, J. Kim, J. C. Morris, M. A. Mintun, Y. I. Sheline, Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans. Proc. Natl. Acad. Sci. U.S.A. 108, 14968-14973 (2011).