Three column intermittent simulated moving bed chromatography: 1. Process description and comparative assessment

Journal of Chromatography A

Volumn 1361, Issue , 2014, Pages 125-138

  Jermann, Simon ^a   Mazzotti, Marco ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

3C ISMB; I SMB; Separation of enantiomers; Simulated moving bed chromatography; Three zone SMB

Indexed keywords

PROCESS DESIGN; PRODUCTIVITY;

3C-ISMB; CHROMATOGRAPHIC PROCESS; COMPARATIVE ASSESSMENT; EXTENSIVE SIMULATIONS; PRODUCTIVITY INCREASE; SEPARATION OF ENANTIOMERS; SIMULATED MOVING BED CHROMATOGRAPHY; THREE ZONES;

COLUMN CHROMATOGRAPHY;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; FLOW RATE; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; PRESSURE; PRODUCTIVITY; SIMULATED MOVING BED CHROMATOGRAPHY; SIMULATION; STEADY STATE; ADSORPTION; CHEMISTRY; COMPARATIVE STUDY; DEVICES; METHODOLOGY; PROCEDURES;

SOLVENT;

ADSORPTION; CHROMATOGRAPHY; RESEARCH DESIGN; SOLVENTS;

EID: 84919690985     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.07.101     Document Type: Article

References (22)

1. D.B. Broughton, C.G. Gerhold, Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets, US Patent 2,985,589 (1961).
2. Ruthven D.M., Ching C.B. Counter-current and simulated counter-current adsorption separation processes. Chem. Eng. Sci. 1989, 44(5):1011-1038.
3. Rajendran A., Paredes G., Mazzotti M. Simulated moving bed chromatography for the separation of enantiomers. J. Chromatogr. A 2009, 1216(4):709-738.
4. Mazzotti M., Storti G., Morbidelli M. Optimal operation of simulated moving bed units for nonlinear chromatographic separations. J. Chromatogr. A 1997, 769(1):3-24.
5. Ludemann-Hombourger O., Pigorini G., Nicoud R.M., Ross D.S., Terfloth G. Application of the "VARICOL" process to the separation of the isomers of the SB-553261 racemate. J. Chromatogr. A 2002, 947(1):59-68.
6. Kloppenburg E., Gilles E.D. A new concept for operating simulated moving-bed processes. Chem. Eng. Technol. 1999, 22(10):813-817.
7. Zhang Z., Morbidelli M., Mazzotti M. Experimental assessment of powerfeed chromatography. AlChE J. 2004, 50(3):625-632.
8. Zang Y., Wankat P.C. SMB operation strategy-partial feed. Ind. Eng. Chem. Res. 2002, 41(10):2504-2511.
9. Schramm H., Kaspereit M., Kienle A., Seidel-Morgenstern A. Simulated moving bed process with cyclic modulation of the feed concentration. J. Chromatogr. A 2003, 1006(1/2):77-86.
10. Hashimoto K., Yamada M., Adachi S., Shirai Y. A simulated moving-bed adsorber with three zones for continuous separation of L-phenylalanine and NaCl. J. Chem. Eng. Jpn. 1989, 22(4):432-434.
11. Zang Y., Wankat P.C. Three-zone simulated moving bed with partial feed and selective withdrawal. Ind. Eng. Chem. Res. 2002, 41(21):5283-5289.
12. Y.M. Koo, J.W. Lee, J.I. Kim, Chromatographic method of using three-zone simulated moving bed process comprising partial recycle, Korean Patent KR 10-2009-0039979 (2007).
13. Lee J.W. Design of modified SMBs and retention behaviors in gradient elution 2007, INHA University, Incheon, (Ph.D. thesis).
14. Katsuo S., Mazzotti M. Intermittent simulated moving bed chromatography: 2. Separation of Tröger's base enantiomers. J. Chromatogr. A 2010, 1217(18):3067-3075.
15. Katsuo S., Langel C., Sandré A.-L., Mazzotti M. Intermittent simulated moving bed chromatography: 3. Separation of Tröger's base enantiomers under nonlinear conditions. J. Chromatogr. A 2011, 1218(52):9345-9352.
16. M. Tanimura, M. Tamura, T. Teshima, Method of chromatographic separation, US Patent 5,064,539 (1991).
17. M. Tanimura, M. Tamura, T. Teshima, Japanese Patent JP-B-H07-046097 (1995).
18. Katsuo S., Mazzotti M. Intermittent simulated moving bed chromatography: 1. Design criteria and cyclic steady-state. J. Chromatogr. A 2010, 1217(8):1354-1361.
19. Guiochon G., Felinger A., Shirazi D.G., Katti A.M. Fundamentals of Preparative and Nonlinear Chromatography 2006, Academic Press, San Diego. second ed.
20. Hindmarsh A.C., Brown P.N., Grant K.E., Lee S.L., Serban R., Shumaker D.E., Woodward C.S. Sundials: suite of nonlinear and differential/algebraic equation solvers. ACM Trans. Math. Softw. 2005, 31(3):363-396.
21. Jermann S., Katsuo S., Mazzotti M. Intermittent simulated moving bed processes for chromatographic three-fraction separation. Org. Process Res. Dev. 2012, 16(2):311-322.
22. Migliorini C., Mazzotti M., Morbidelli M. Robust design of countercurrent adsorption separation processes: 5. Nonconstant selectivity. AlChE J. 2000, 46(7):1384-1399.