Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of FLG gene mutations

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 6, 2014, Pages 1459-1461.e7

  Pellerin, Laurence ^a,b,c   Paul, Carle ^a,b,c,d   Schmitt, Anne Marie ^e   Serre, Guy ^a,b,c   Simon, Michel ^a,b,c  

^a CNRS   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d TOULOUSE UNIVERSITY HOSPITAL   (France)

^e Centre d'Immunologie Pierre Fabre   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN HYDROLASE; CALPAIN 1; CASPASE 14; FILAGGRIN; PROFILAGGRIN; TISSUE EXTRACT; CALPAIN; CAPN1 PROTEIN, HUMAN; CYSTEINE PROTEINASE; INTERMEDIATE FILAMENT PROTEIN; STOP CODON;

ADULT; ADULT DISEASE; ATOPIC DERMATITIS; CASE CONTROL STUDY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; DRY SKIN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOTYPE; HUMAN; HUMAN CELL; KERATINOCYTE; LETTER; NONSENSE MUTATION; WESTERN BLOTTING; FEMALE; GENETICS; MALE; METABOLISM; SKIN; STOP CODON;

ADULT; CALPAIN; CASPASE 14; CODON, NONSENSE; CYSTEINE ENDOPEPTIDASES; DERMATITIS, ATOPIC; DOWN-REGULATION; FEMALE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MALE; SKIN;

EID: 84919684807     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.056     Document Type: Article

References (11)

1. S. Kezic, N. Novak, I. Jasaka, J.M. Jungersted, M. Simon, and J.M. Brandner Skin barrier in atopic dermatitis Front Biosci 19 2014 542 556
2. S.J. Brown, and W.H. McLean One remarkable molecule: filaggrin J Invest Dermatol 132 2011 751 762
3. B.A. Dale, K.A. Resing, and J.D. Lonsdale-Eccles Filaggrin: a keratin filament associated protein Ann N Y Acad Sci 455 1985 330 342
4. Pendaries-Rahoul V, Malaisse J, Pellerin L, Le Lamer M, Nachat R, Kezic S, et al. Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte terminal differentiation [published online ahead of print June 13, 2014]. J Invest Dermatol doi:10.1038/jid.2014.259.
5. H. Kawasaki, K. Nagao, A. Kubo, T. Hata, A. Shimizu, and H. Mizuno Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice J Allergy Clin Immunol 129 2012 1538 1546
6. L. Pellerin, J. Henry, C.Y.S. Hsu, S. Balica, C. Jean-Decoster, and M.C. Méchin Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin J Allergy Clin Immunol 131 2013 1094 1102
7. S.P. Tan, S. Abdul-Ghaffar, R.B. Weller, and S.B. Brown Protease-antiprotease imbalance may be linked to potential defects in profilaggrin proteolysis in atopic dermatitis Br J Dermatol 166 2012 1137 1140
8. M. Yamamoto, Y. Kamata, T. Iida, H. Fukushima, J. Nomura, and M. Saito Quantification of activated and total caspase-14 with newly developed ELISA systems in normal and atopic skin J Dermatol Sci 61 2011 110 117
9. Y. Kamata, M. Yamamoto, F. Kawakami, R. Tsuboi, A. Takeda, and K. Ishihara Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis J Biol Chem 286 2011 8204 8212
10. L. Pellerin, J. Henry, C.Y. Hsu, S. Balica, C. Jean-Decoster, and M.C. Méchin Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin J Allergy Clin Immunol 131 2013 1094 1102
11. M. Simon, M. Sebbag, M. Haftek, C. Vincent, E. Girbal-Neuhauser, and J. Rakotoarivony Monoclonal antibodies to human epidermal filaggrin, some not recognizing profilaggrin J Invest Dermatol 105 1995 432 437