A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders

Blood

Volumn 124, Issue 25, 2014, Pages 3768-3771

  Velusamy, Thirunavukkarasu ^a   Kiel, Mark J ^a   Sahasrabuddhe, Anagh A ^a   Rolland, Delphine ^a   Dixon, Catherine A ^a   Bailey, Nathanael G ^a   Betz, Bryan L ^a   Brown, Noah A ^a   Hristov, Alexandra C ^a   Wilcox, Ryan A ^a   Miranda, Roberto N ^b   Medeiros, L Jeffrey ^b   Jeon, Yoon K ^c   Inamdar, Kedar V ^d   Lim, Megan S ^a   Elenitoba Johnson, Kojo S J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Seoul National University Hospital   (South Korea)

^d HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD30 ANTIGEN; NUCLEOPHOSMIN; PROTEIN KINASE TYK2; SHORT HAIRPIN RNA; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTOME; NUCLEAR PROTEIN; ONCOPROTEIN; TYK2 PROTEIN, HUMAN;

ANGIOIMMUNOBLASTIC T CELL LYMPHOMA; ARTICLE; CHROMOSOME TRANSLOCATION; ENTEROPATHY ASSOCIATED T CELL LYMPHOMA; ENZYME ACTIVE SITE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; IMMUNOHISTOCHEMISTRY; LYMPHOPROLIFERATIVE DISEASE; NK T CELL LYMPHOMA; OLIGOMERIZATION; SIGNAL TRANSDUCTION; T CELL LYMPHOMA; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; LARGE CELL LYMPHOMA; LYMPHOMATOID PAPULOSIS; METABOLISM; MUTATION; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SKIN TUMOR; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIGENS, CD30; BLOTTING, WESTERN; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOMA, PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL; LYMPHOMATOID PAPULOSIS; MUTATION; NUCLEAR PROTEINS; ONCOGENE FUSION; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANSCRIPTOME; TYK2 KINASE;

EID: 84919663234     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-07-588434     Document Type: Article

References (12)

1. Rowley JD. Chromosome translocations: dangerous liaisons revisited. Nat Rev Cancer. 2001;1(3):245-250.
2. Mitelman F, Johansson B, Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007;7(4):233-245.
3. Greuber EK, Smith-Pearson P, Wang J, Pendergast AM. Role of ABL family kinases in cancer: from leukaemia to solid tumours. Nat Rev Cancer. 2013;13(8):559-571.
4. Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC; 2008.
5. Iyer MK, Chinnaiyan AM, Maher CA. ChimeraScan: a tool for identifying chimeric transcription in sequencing data. Bioinformatics. 2011;27(20):2903-2904.
6. Sahasrabuddhe AA, Chen X, Chung F, Velusamy T, Lim MS, Elenitoba-Johnson KS. Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation [published online ahead of print January 27, 2014]. Oncogene.
7. Chen YW, Liang AC, Au WY, et al. Multiple BCL6 translocation partners in individual cases of gastric lymphoma. Blood. 2003;102:1931-2; author reply 2.
8. Harper DP, Aplan PD. Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects. Cancer Res. 2008;68(24):10024-10027.
9. Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1):11-23.
10. Sanda T, Tyner JW, Gutierrez A, et al. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer discovery. 2013;3:564-77.
11. Pearson JD, Lee JK, Bacani JT, Lai R, Ingham RJ. NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases. Journal of signal transduction. 2012;2012:123253.
12. Bischof D, Pulford K, Mason DY, Morris SW. Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol Cell Biol. 1997;17(4):2312-2325.