The prevalence and burden of bipolar depression

Journal of Affective Disorders

Volumn 169, Issue S1, 2014, Pages S3-S11

  Miller, Shefali ^a,b   Dell'Osso, Bernardo ^a,c   Ketter, Terence A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Bipolar disorder; Burden; Cost; Depression; Functioning; Prevalence

Indexed keywords

BIPOLAR DEPRESSION; BIPOLAR DISORDER; CAREGIVER BURDEN; CLIMACTERIUM; COGNITIVE DEFECT; COGNITIVE THERAPY; DATA BASE; DEPRESSION; DISEASE ASSOCIATION; FAMILY FUNCTIONING; FUNCTIONAL DISEASE; HEALTH CARE COST; HUMAN; HUMAN RELATION; HYPOMANIA; LEARNING; MAJOR DEPRESSION; MEDLINE; MIXED MANIA AND DEPRESSION; POLYPHARMACY; PREVALENCE; PRODUCTIVITY; QUALITY OF LIFE; RESPONSIBILITY; REVIEW; RISK FACTOR; SOCIOECONOMICS; SUICIDAL IDEATION; SUICIDE; SUICIDE ATTEMPT; SYMPTOM;

EID: 84919620894     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/S0165-0327(14)70003-5     Document Type: Review

References (91)

1. L.L. Altshuler, R.W. Kupka, G. Hellemann, M.A. Frye, C.A. Sugar, S.L. McElroy, W.A. Nolen, H. Grunze, G.S. Leverich, P.E. Keck, M. Zermeno, R.M. Post, T. Suppes Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network Am. J. Psychiatry 167 6 2010 708 715
2. L.L. Altshuler, R.M. Post, D.O. Black, P.E. Keck Jr., W.A. Nolen, M.A. Frye, T. Suppes, H. Grunze, R.W. Kupka, G.S. Leverich, S.L. McElroy, J. Walden, J. Mintz Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study J. Clin. Psychiatry 67 10 2006 1551 1560
3. H. Amini, V. Sharifi Quality of life in bipolar type I disorder in a one-year followup Depress. Res Treat. 2012 2012 860745
4. R. Baldessarini, H. Henk, A. Sklar, J. Chang, L. Leahy Psychotropic medications for patients with bipolar disorder in the United States: polytherapy and adherence Psychiatr. Serv. 59 10 2008 1175 1183
5. R.J. Baldessarini, M. Pompili, L. Tondo Suicide in bipolar disorder: Risks and management CNS Spectr. 11 6 2006 465 471
6. R.J. Baldessarini, J. Undurraga, G.H. Vazquez, L. Tondo, P. Salvatore, K. Ha, H.M. Khalsa, B. Lepri, T.H. Ha, J.S. Chang, M. Tohen, E. Vieta Predominant recurrence polarity among 928 adult international bipolar I disorder patients Acta Psychiatr. Scand. 125 4 2012 293 302
7. L. Berk, M. Berk, S. Dodd, C. Kelly, S. Cvetkovski, A.F. Jorm Evaluation of the acceptability and usefulness of an information website for caregivers of people with bipolar disorder BMC Med. 11 2013 162
8. C.M. Bonnin, A. Martinez-Aran, C. Torrent, I. Pacchiarotti, A.R. Rosa, C. Franco, A. Murru, J. Sanchez-Moreno, E. Vieta Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study J. Affect. Disord. 121 1-2 2010 156 160
9. C. Bourne, O. Aydemir, V. Balanza-Martinez, E. Bora, S. Brissos, J.T. Cavanagh, L. Clark, Z. Cubukcuoglu, V.V. Dias, S. Dittmann, I.N. Ferrier, D.E. Fleck, S. Frangou, P. Gallagher, L. Jones, T. Kieseppa, A. Martinez-Aran, I. Melle, P.B. Moore, M. Mur, A. Pfennig, A. Raust, V. Senturk, C. Simonsen, D.J. Smith, D.S. Bio, M.G. Soeiro-de-Souza, S.D. Stoddart, K. Sundet, A. Szoke, J.M. Thompson, C. Torrent, T. Zalla, N. Craddock, O.A. Andreassen, M. Leboyer, E. Vieta, M. Bauer, P.D. Worhunsky, C. Tzagarakis, R.D. Rogers, J.R. Geddes, G.M. Goodwin Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis Acta Psychiatr. Scand. 128 3 2013 149 162
10. L. Bryant-Comstock, M. Stender, G. Devercelli Health care utilization and costs among privately insured patients with bipolar I disorder Bipolar Disord. 4 6 2002 398 405
11. J.R. Calabrese, R.M. Hirschfeld, M.A. Frye, M.L. Reed Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample. J. Clin. Psychiatry 65 11 2004 1499 1504
12. C. De Dios, E. Ezquiaga, A. Garcia, B. Soler, E. Vieta Time spent with symptoms in a cohort of bipolar disorder outpatients in Spain: a prospective, 18-month follow-up study J. Affect. Disord. 125 1-3 2010 74 81
13. T. Deckersbach, A.A. Nierenberg, R. Kessler, H.G. Lund, R.M. Ametrano, G. Sachs, S.L. Rauch, D. Dougherty RESEARCH: Cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptoms CNS Neurosci. Ther. 16 5 2010 298 307
14. B. Dell'osso, M. Buoli, S. Bortolussi, G. Camuri, V. Vecchi, A.C. Altamura Patterns of Axis I comorbidity in relation to age in patients with Bipolar Disorder: a cross-sectional analysis J. Affect. Disord. 130 1-2 2011 318 322
15. C.A. Depp, C.E. Davis, D. Mittal, T.L. Patterson, D.V. Jeste Health-related quality of life and functioning of middle-aged and elderly adults with bipolar disorder J. Clin. Psychiatry 67 2 2006 215 221
16. S.C. Dilsaver An estimate of the minimum economic burden of bipolar I and II disorders in the United States: 2009 J. Affect. Disord. 129 1-3 2011 79 83
17. K. Duckworth, L. Halpern Peer support and peer-led family support for persons living with schizophrenia Curr. Opin. Psychiatry 27 3 2014 216 221
18. J.G. Fiedorowicz, N.M. Palagummi, V.L. Forman-Hoffman, D.D. Miller, W.G. Haynes Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder Ann. Clin. Psychiatry 20 3 2008 131 137
19. M.A. Frye, T.A. Ketter, G.S. Leverich, T. Huggins, C. Lantz, K.D. Denicoff, R.M. Post The increasing use of polypharmacotherapy for refractory mood disorders: 22 years of study J. Clin. Psychiatry 61 1 2000 9 15
20. A.M. Gadermann, J. Alonso, G. Vilagut, A.M. Zaslavsky, R.C. Kessler Comorbidity and disease burden in the National Comorbidity Survey Replication (NCS-R) Depress. Anxiety 29 9 2012 797 806
21. H.H. Gardner, N.L. Kleinman, R.A. Brook, K. Rajagopalan, T.J. Brizee, J.E. Smeeding The economic impact of bipolar disorder in an employed population from an employer perspective J. Clin. Psychiatry 67 8 2006 1209 1218
22. S.N. Ghaemi, D.J. Hsu, F. Soldani, F.K. Goodwin Antidepressants in bipolar disorder: the case for caution Bipolar Disord. 5 6 2003 421 433
23. E. Gilbert, S. Marwaha Predictors of employment in bipolar disorder: A systematic review J. Affect. Disord. 145 2 2013 156 164
24. M.J. Gitlin, J. Mintz, K. Sokolski, C. Hammen, L.L. Altshuler Subsyndromal depressive symptoms after symptomatic recovery from mania are associated with delayed functional recovery J. Clin. Psychiatry 72 5 2011 692 697
25. F.S. Goes, M.G. McCusker, O.J. Bienvenu, D.F. Mackinnon, F.M. Mondimore, B. Schweizer, J.R. Depaulo, J.B. Potash Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder Psychol. Med. 42 7 2012 1449 1459
26. J.F. Goldberg, J.O. Brooks III, K. Kurita, J.C. Hoblyn, S.N. Ghaemi, R.H. Perlis, D.J. Miklowitz, T.A. Ketter, G.S. Sachs, M.E. Thase Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD J. Clin. Psychiatry 70 2 2009 155 162
27. J.F. Goldberg, M. Harrow A 15-year prospective follow-up of bipolar affective disorders: comparisons with unipolar nonpsychotic depression Bipolar Disord. 13 2 2011 155 163
28. J.F. Goldberg, R.H. Perlis, S.N. Ghaemi, J.R. Calabrese, C.L. Bowden, S. Wisniewski, D.J. Miklowitz, G.S. Sachs, M.E. Thase Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD Am. J. Psychiatry 164 9 2007 1348 1355
29. B.I. Goldstein, S.M. Liu, N. Zivkovic, A. Schaffer, L.C. Chien, C. Blanco The burden of obesity among adults with bipolar disorder in the United States Bipolar Disord 13 4 2011 387 395
30. F.K. Goodwin, K.R. Jamison Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression 2nd ed. 2007 Oxford University Press New York, NY
31. J.J. Guo, P.E. Keck Jr., H. Li, R. Jang, C.M. Kelton Treatment costs and health care utilization for patients with bipolar disorder in a large managed care population Value Health 11 3 2008 416 423
32. J.J. Guo, P.E. Keck, H. Li, N.C. Patel Treatment costs related to bipolar disorder and comorbid conditions among Medicaid patients with bipolar disorder Psychiatr. Serv. 58 8 2007 1073 1078
33. L. Gutierrez-Rojas, M. Gurpegui, J.L. Ayuso-Mateos, J.A. Gutierrez-Ariza, M. Ruiz-Veguilla, D. Jurado Quality of life in bipolar disorder patients: a comparison with a general population sample Bipolar Disord. 10 5 2008 625 634
34. R.T. Joffe, G.M. MacQueen, M. Marriott, Y.L. Trevor A prospective, longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders Bipolar Disord. 6 1 2004 62 66
35. L.L. Judd, H.S. Akiskal The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases J. Affect. Disord. 73 1-2 2003 123 131
36. L.L. Judd, H.S. Akiskal, P.J. Schettler, W. Coryell, J. Endicott, J.D. Maser, D.A. Solomon, A.C. Leon, M.B. Keller A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder Arch. Gen. Psychiatry 60 3 2003 261 269
37. L.L. Judd, H.S. Akiskal, P.J. Schettler, J. Endicott, A.C. Leon, D.A. Solomon, W. Coryell, J.D. Maser, M.B. Keller Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study Arch. Gen. Psychiatry 62 12 2005 1322 1330
38. L.L. Judd, H.S. Akiskal, P.J. Schettler, J. Endicott, J. Maser, D.A. Solomon, A.C. Leon, J.A. Rice, M.B. Keller The long-term natural history of the weekly symptomatic status of bipolar I disorder Arch. Gen. Psychiatry 59 6 2002 530 537
39. D.E. Kemp, K. Gao, P. Chan, S.J. Ganocy, R.L. Findling, J.R. Calabrese Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome Bipolar Disord. 12 4 2010 404 413
40. R.C. Kessler, H.S. Akiskal, M. Ames, H. Birnbaum, P. Greenberg, R.M. Hirschfeld, R. Jin, K.R. Merikangas, G.E. Simon, P.S. Wang Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers Am. J. Psychiatry 163 9 2006 1561 1568
41. R.C. Kessler, P. Berglund, O. Demler, R. Jin, K.R. Merikangas, E.E. Walters Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication Arch. Gen. Psychiatry 62 6 2005 593 602
42. N.L. Kleinman, R.A. Brook, K. Rajagopalan, H.H. Gardner, T.J. Brizee, J.E. Smeeding Lost time, absence costs, and reduced productivity output for employees with bipolar disorder J. Occup. Environ. Med. 47 11 2005 1117 1124
43. R.W. Kupka, L.L. Altshuler, W.A. Nolen, T. Suppes, D.A. Luckenbaugh, G.S. Leverich, M.A. Frye, P.E. Keck Jr., S.L. McElroy, H. Grunze, R.M. Post Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder Bipolar Disord. 9 5 2007 531 535
44. M.M. Kurtz, R.T. Gerraty A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state Neuropsychology 23 5 2009 551 562
45. G.S. Leverich, L.L. Altshuler, M.A. Frye, T. Suppes, S.L. McElroy, P.E. Keck Jr., R.W. Kupka, K.D. Denicoff, W.A. Nolen, H. Grunze, M.I. Martinez, R.M. Post Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers Am. J. Psychiatry 163 2 2006 232 239
46. P.V. Magalhaes, F. Kapczinski, A.A. Nierenberg, T. Deckersbach, D. Weisinger, S. Dodd, M. Berk Illness burden and medical comorbidity in the Systematic Treatment Enhancement Program for Bipolar Disorder Acta Psychiatr. Scand. 125 4 2012 303 308
47. L.B. Marangell, E.B. Dennehy, S. Miyahara, S.R. Wisniewski, M.S. Bauer, M.H. Rapaport, M.H. Allen The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD J. Affect. Disord. 114 1-3 2009 58 67
48. L.B. Marangell, E.B. Dennehy, S.R. Wisniewski, M.S. Bauer, S. Miyahara, M.H. Allen, M. Martinez, R.K. Al Jurdi, M.E. Thase Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD J. Clin. Psychiatry 69 6 2008 916 922
49. W.K. Marsh, T.A. Ketter, N.L. Rasgon Increased depressive symptoms in menopausal age women with bipolar disorder: age and gender comparison J. Psychiatr. Res. 43 8 2009 798 802
50. S.L. McElroy, L.L. Altshuler, T. Suppes, P.E. Keck Jr., M.A. Frye, K.D. Denicoff, W.A. Nolen, R.W. Kupka, G.S. Leverich, J.R. Rochussen, A.J. Rush, R.M. Post Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder Am. J. Psychiatry 158 3 2001 420 426
51. R.S. McIntyre, J.Z. Konarski, V.L. Misener, S.H. Kennedy Bipolar disorder and diabetes mellitus: epidemiology, etiology, and treatment implications Ann. Clin. Psychiatry 17 2 2005 83 93
52. R.S. McIntyre, J.Z. Konarski, J.K. Soczynska, K. Wilkins, G. Panjwani, B. Bouffard, A. Bottas, S.H. Kennedy Medical comorbidity in bipolar disorder: implications for functional outcomes and health service utilization Psychiatr. Serv. 57 8 2006 1140 1144
53. B.J. McMorris, K.E. Downs, J.M. Panish, R. Dirani Workplace productivity, employment issues, and resource utilization in patients with bipolar I disorder J. Med. Econ. 13 1 2010 23 32
54. K.R. Merikangas, H.S. Akiskal, J. Angst, P.E. Greenberg, R.M. Hirschfeld, M. Petukhova, R.C. Kessler Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey Replication Arch. Gen. Psychiatry 64 5 2007 543 552
55. K.R. Merikangas, L. Cui, G. Kattan, G.A. Carlson, E.A. Youngstrom, J. Angst Mania with and without depression in a community sample of US adolescents Arch. Gen. Psychiatry 69 9 2012 943 951
56. K.R. Merikangas, R. Jin, J.P. He, R.C. Kessler, S. Lee, N.A. Sampson, M.C. Viana, L.H. Andrade, C. Hu, E.G. Karam, M. Ladea, M.E. Medina-Mora, Y. Ono, J. Posada-Villa, R. Sagar, J.E. Wells, Z. Zarkov Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative Arch. Gen. Psychiatry 68 3 2011 241 251
57. D.J. Miklowitz Functional impairment, stress, and psychosocial intervention in bipolar disorder Curr. Psychiatry Rep. 13 6 2011 504 512
58. C.J. Miller, K.M. Abraham, L.A. Bajor, Z. Lai, H.M. Kim, K.M. Nord, D.E. Goodrich, M.S. Bauer, A.M. Kilbourne Quality of life among patients with bipolar disorder in primary care versus community mental health settings J. Affect. Disord. 146 1 2013 100 105
59. M.J. Ostacher, A.A. Nierenberg, D.V. Iosifescu, P. Eidelman, H.G. Lund, R.M. Ametrano, R. Kaczynski, J. Calabrese, D.J. Miklowitz, G.S. Sachs, D.A. Perlick Correlates of subjective and objective burden among caregivers of patients with bipolar disorder Acta Psychiatr. Scand. 118 1 2008 49 56
60. M.W. Otto, N.M. Simon, S.R. Wisniewski, D.J. Miklowitz, J.N. Kogan, N.A. Reilly-Harrington, E. Frank, A.A. Nierenberg, L.B. Marangell, K. Sagduyu, R.D. Weiss, S. Miyahara, M.E. Thas, G.S. Sachs, M.H. Pollack Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders Br. J. Psychiatry 189 2006 20 25
61. P.B. Peele, Y. Xu, D.J. Kupfer Insurance expenditures on bipolar disorder: clinical and parity implications Am. J. Psychiatry 160 7 2003 1286 1290
62. D.A. Perlick, D.J. Miklowitz, N. Lopez, J. Chou, C. Kalvin, V. Adzhiashvili, A. Aronson Family-focused treatment for caregivers of patients with bipolar disorder Bipolar Disord. 12 6 2010 627 637
63. D.A. Perlick, R.A. Rosenheck, J.F. Clarkin, P.K. Maciejewski, J. Sirey, E. Struening, B.G. Link Impact of family burden and affective response on clinical outcome among patients with bipolar disorder Psychiatr. Serv. 55 9 2004 1029 1035
64. D.A. Perlick, R.A. Rosenheck, D.J. Miklowitz, C. Chessick, N. Wolff, R. Kaczynski, M. Ostacher, J. Patel, R. Desai Prevalence and correlates of burden among caregivers of patients with bipolar disorder enrolled in the systematic treatment enhancement program for bipolar disorder Bipolar Disord. 9 3 2007 262 273
65. R.H. Perlis, S. Miyahara, L.B. Marangell, S.R. Wisniewski, M. Ostacher, M.P. DelBello, C.L. Bowden, G.S. Sachs, A.A. Nierenberg Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD) Biol. Psychiatry 55 9 2004 875 881
66. R.M. Post, D.A. Luckenbaugh, G.S. Leverich, L.L. Altshuler, M.A. Frye, T. Suppes, P.E. Keck, S.L. McElroy, W.A. Nolen, R. Kupka, H. Grunze, J. Walden Incidence of childhood-onset bipolar illness in the USA and Europe Br. J. Psychiatry 192 2 2008 150 151
67. D.A. Revicki, L.S. Matza, E. Flood, A. Lloyd Bipolar disorder and health-related quality of life: review of burden of disease and clinical trials Pharmacoeconomics 23 6 2005 583 594
68. A.R. Rosa, M. Reinares, E.E. Michalak, C.M. Bonnin, B. Sole, C. Franco, M. Comes, C. Torrent, F. Kapczinski, E. Vieta Functional impairment and disability across mood states in bipolar disorder Value Health 13 8 2010 984 988
69. B. Roshanaei-Moghaddam, W. Katon Premature mortality from general medical illnesses among persons with bipolar disorder: a review Psychiatr. Serv. 60 2 2009 147 156
70. N.D. Shippee, N.D. Shah, M.D. Williams, J.P. Moriarty, M.A. Frye, J.Y. Ziegenfuss Differences in demographic composition and in work, social, and functional limitations among the populations with unipolar depression and bipolar disorder: results from a nationally representative sample Health Qual. Life Outcomes 9 2011 90
71. P. Sierra, L. Livianos, L. Rojo Quality of life for patients with bipolar disorder: relationship with clinical and demographic variables Bipolar Disord. 7 2 2005 159 165
72. G.E. Simon, M.S. Bauer, E.J. Ludman, B.H. Operskalski, J. Unutzer Mood symptoms, functional impairment, and disability in people with bipolar disorder: specific effects of mania and depression J. Clin. Psychiatry 68 8 2007 1237 1245
73. G.E. Simon, E.J. Ludman, J. Unutzer, B.H. Operskalski, M.S. Bauer Severity of mood symptoms and work productivity in people treated for bipolar disorder Bipolar Disord. 10 6 2008 718 725
74. B. Solé, C.M. Bonnin, C. Torrent, V. Balanza-Martinez, R. Tabares-Seisdedos, D. Popovic, A. Martinez-Aran, E. Vieta Neurocognitive impairment and psychosocial functioning in bipolar II disorder Acta Psychiatr. Scand. 125 4 2012 309 317
75. A. Steele, N. Maruyama, I. Galynker Psychiatric symptoms in caregivers of patients with bipolar disorder: a review J. Affect. Disord. 121 1-2 2010 10 21
76. A. Stringaris, P. Santosh, E. Leibenluft, R. Goodman Youth meeting symptom and impairment criteria for mania-like episodes lasting less than four days: an epidemiological enquiry J. Child. Psychol. Psychiatry 51 1 2010 31 38
77. C. Torrent, C.M. Bonnin, A. Martinez-Aran, J. Valle, B.L. Amann, A. Gonzalez-Pinto, J.M. Crespo, A. Ibanez, M.P. Garcia-Portilla, R. Tabares-Seisdedos, C. Arango, F. Colom, B. Sole, I. Pacchiarotti, A.R. Rosa, J.L. Ayuso-Mateos, C. Anaya, P. Fernandez, R. Landin-Romero, S. Alonso-Lana, J. Ortiz-Gil, B. Segura, S. Barbeito, P. Vega, M. Fernandez, A. Ugarte, M. Subira, E. Cerrillo, N. Custal, J.M. Menchon, J. Saiz-Ruiz, J.M. Rodao, S. Isella, A. Alegria, S. Al-Halabi, J. Bobes, G. Galvan, P.A. Saiz, V. Balanza-Martinez, G. Selva, I. Fuentes-Dura, P. Correa, M. Mayoral, G. Chiclana, J. Merchan-Naranjo, M. Rapado-Castro, M. Salamero, E. Vieta Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study Am. J. Psychiatry 170 8 2013 852 859
78. J. Undurraga, R.J. Baldessarini, M. Valenti, I. Pacchiarotti, L. Tondo, G. Vazquez, E. Vieta Bipolar depression: clinical correlates of receiving antidepressants J. Affect. Disord. 139 1 2012 89 93
79. J. Undurraga, R.J. Baldessarini, M. Valenti, I. Pacchiarotti, E. Vieta Suicidal risk factors in bipolar I and II disorder patients J. Clin. Psychiatry 73 6 2012 778 782
80. H.M. Valtonen, K. Suominen, J. Haukka, O. Mantere, S. Leppamaki, P. Arvilommi, E.T. Isometsa Differences in incidence of suicide attempts during phases of bipolar I and II disorders Bipolar Disord. 10 5 2008 588 596
81. D. Vancampfort, K. Vansteelandt, C.U. Correll, A.J. Mitchell, A. De Herdt, P. Sienaert, M. Probst, M. De Hert Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators Am. J. Psychiatry 170 3 2013 265 274
82. C. Vojta, B. Kinosian, H. Glick, L. Altshuler, M.S. Bauer Self-reported quality of life across mood states in bipolar disorder Compr. Psychiatry 42 3 2001 190 195
83. N.S. Weber, J.A. Fisher, D.N. Cowan, D.W. Niebuhr Psychiatric and general medical conditions comorbid with bipolar disorder in the National Hospital Discharge Survey Psychiatr. Serv. 62 10 2011 1152 1158
84. R.D. Weiss, M.J. Ostacher, M.W. Otto, J.R. Calabrese, M. Fossey, S.R. Wisniewski, C.L. Bowden, A.A. Nierenberg, M.H. Pollack, I.M. Salloum, N.M. Simon, M.E. Thase, G.S. Sachs Does recovery from substance use disorder matter in patients with bipolar disorder? J. Clin. Psychiatry 66 6 2005 730 735
85. J. Westman, J. Hallgren, K. Wahlbeck, D. Erlinge, L. Alfredsson, U. Osby Cardiovascular mortality in bipolar disorder: a population-based cohort study in Sweden BMJ Open 3 4 2013
86. M.D. Williams, N.D. Shah, A.E. Wagie, D.L. Wood, M.A. Frye Direct costs of bipolar disorder versus other chronic conditions: an employer-based health plan analysis Psychiatr. Serv. 62 9 2011 1073 1078
87. World Health Organization The global burden of disease: 2004 update 2008 World Health Organization Geneva, Switzerland http://www.who.int/healthinfo/global-burden-disease/GBD-report-2004update-full.pdf 2008 Accessed October 17, 2014.
88. R.J. Wyatt, I. Henter An economic evaluation of manic-depressive illness-1991 Soc. Psychiatry Psychiatr. Epidemiol. 30 5 1995 213 219
89. L.N. Yatham, Y. Lecrubier, R.R. Fieve, K.H. Davis, S.D. Harris, A.A. Krishnan Quality of life in patients with bipolar I depression: data from 920 patients Bipolar Disord. 6 5 2004 379 385
90. H. Zhang, S.R. Wisniewski, M.S. Bauer, G.S. Sachs, M.E. Thase Comparisons of perceived quality of life across clinical states in bipolar disorder: data from the first 2000 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) participants Compr. Psychiatry 47 3 2006 161 168
91. M. Zimmerman, J.N. Galione, I. Chelminski, D. Young, K. Dalrymple, C.J. Ruggero Sustained unemployment in psychiatric outpatients with bipolar disorder: frequency and association with demographic variables and comorbid disorders Bipolar Disord. 12 7 2010 720 726