Early Reperfusion rates with IV tPA Are determined by CTA clot characteristics

American Journal of Neuroradiology

Volumn 35, Issue 12, 2014, Pages 2265-2272

  Mishra, S M ^a   Dykeman, J ^a   Sajobi, T T ^a,b,h   Trivedi, A ^a   Almekhlafi, M ^a,d,g   Sohn, S I ^c   Bal, S ^e   Qazi, E ^a,g   Calleja, A ^f   Eesa, M ^a,g   Goyal, M ^a,g,h   Demchuk, A M ^a,g,h   Menon, B K ^a,b,g,h  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c Dongsan Medical Center   (South Korea)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^e UNIVERSITY OF MANITOBA   (Canada)

^f UNIVERSITY OF VALLADOLID   (Spain)

^g Seaman Family MR Research Centre   (Canada)

^h UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR; FIBRINOLYTIC AGENT;

AGED; ALGORITHM; ARTICLE; BLOOD CLOT; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CLINICAL ASSESSMENT; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; DATA BASE; DISEASE REGISTRY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; REPERFUSION; SENSITIVITY ANALYSIS; BRAIN ANGIOGRAPHY; FIBRINOLYTIC THERAPY; IMAGE PROCESSING; INTRACRANIAL THROMBOSIS; MIDDLE AGED; PROCEDURES; RADIOGRAPHY; REPRODUCIBILITY; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CEREBRAL ANGIOGRAPHY; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTRACRANIAL THROMBOSIS; MALE; MIDDLE AGED; REPERFUSION; REPRODUCIBILITY OF RESULTS; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84919495106     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A4048     Document Type: Article

References (25)

1. von Kummer R, Meyding-Lamade U, Forsting M, et al. Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk. AJNR Am J Neuroradiol 1994;15:9-15.
2. Leys D, Pruvo JP, Godefroy O, et al. Prevalence and significance of hyperdense middle cerebral artery in acute stroke. Stroke 1992; 23:317-24.
3. Riedel CH, Jensen U, Rohr A, et al. Assessment of thrombus in acute middle cerebral artery occlusion using thin-slice nonenhanced computed tomography reconstructions. Stroke 2010;41:1659-64.
4. Moulin T, Cattin F, Crepin-Leblond T, et al. Early CT signs in acute middle cerebral artery infarction: predictive value for subsequent infarct locations and outcome. Neurology 1996;47:366-75.
5. Tomsick T, Brott T, Barsan W, et al. Prognostic value of the hyperdense middle cerebral artery sign and stroke scale score before ultraearly thrombolytic therapy. AJNR Am J Neuroradiol 1996;17: 79-85.
6. Somford DM, Nederkoorn PJ, Rutgers DR, et al. Proximal and distal hyperattenuating middle cerebral artery signs at CT: different prognostic implications. Radiology 2002;223:667-71.
7. Leary MC, Kidwell CS, Villablanca JP, et al. Validation of computed tomographic middle cerebral artery "dot" sign: An angiographic correlation study. Stroke 2003;34:2636-40.
8. Barber PA, Demchuk AM, Hudon ME, et al. Hyperdense Sylvian fissure MCA "dot" sign: A CT marker of acute ischemia. Stroke 2001;32:84-88.
9. Riedel CH, Zimmermann P, Jensen-Kondering U, et al. The importance of size: Successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length. Stroke 2011;42:1775-77.
10. Shobha N, Bal S, Boyko M, et al. Measurement of length of hyperdense MCA sign in acute ischemic stroke predicts disappearance after IV tPA. J Neuroimaging 2014;24:7-10.
11. Bhatia R, Hill MD, Shobha N, et al. Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action. Stroke 2010;41:2254-58.
12. Puetz V, Dzialowski I, Hill MD, et al. Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: The clot burden score. Int J Stroke 2008;3:230-36.
13. Lee KY, Han SW, Kim SH, et al. Early recanalization after intravenous administration of recombinant tissue plasminogen activator as assessed by pre- And post-thrombolytic angiography in acute ischemic stroke patients. Stroke 2007;38:192-93.
14. Saqqur M, Tsivgoulis G, Molina CA, et al. Residual flow at the site of intracranial occlusionontranscranial Doppler predicts response to intravenous thrombolysis: A multi-center study. Cerebrovasc Dis 2009;27:5-12.
15. Ma M, Berger J. A novel TCD grading system for residual flow in stroke patients. Stroke 2001;32:2446.
16. Rha JH, Saver JL. The impact of recanalization on ischemic stroke outcome: A meta-analysis. Stroke 2007;38:967-73.
17. Wintermark M, Albers GW, Broderick JP, et al. Acute stroke imaging research roadmap II. Stroke 2013;44:2628-39.
18. Lemon SC, Roy J, Clark MA, et al. Classification and regression tree analysis in public health: Methodological review and comparison with logistic regression. Ann Behav Med 2003;26:172-81.
19. Menon BK, Smith EE, Coutts SB, et al. Leptomeningeal collaterals are associated with modifiable metabolic risk factors. Ann Neurol 2013;74:241-48.
20. Hirano T, Sasaki M, Mori E, et al. Residual vessel length on magnetic resonance angiography identifies poor responders to alteplase in acute middle cerebral artery occlusion patients: Exploratory analysis of the Japan Alteplase Clinical Trial II. Stroke 2010;41:2828-33.
21. Saarinen JT, Sillanpaa N, Rusanen H, et al. The mid-M1 segment of the middle cerebral artery is a cutoff clot location for good outcome in intravenous thrombolysis. Eur J Neurol 2012;19:1121-27.
22. Anand M, Rajagopal K, Rajagopal KR. A model for the formation and lysis of blood clots. Pathophysiol Haemost Thromb 2005;34: 109-20.
23. Blanke H, Cohen M, Karsch KR, et al. Prevalence and significance of residual flow to the infarct zone during the acute phase of myocardial infarction. J Am Coll Cardiol 1985;5:827-31.
24. Liebeskind DS, Sanossian N, Yong WH, et al. CT and MR Iearly vessel signs reflect clot composition in acute stroke. Stroke 2011;42: 1237-43.
25. Moftakhar P, English JD, Cooke DL, et al. Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke. Stroke 2013;44:243-45.