Association of tagging SNPs in the MTHFR gene with risk of type 2 diabetes mellitus and serum homocysteine levels in a Chinese population

Disease Markers

Volumn 2014, Issue , 2014, Pages

  Wang, Han ^a   Hu, Cong ^b   Xiao, Shu Hui ^c   Wan, Bin ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c LINYI PEOPLE'S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

ADULT; AGED; ALLELE; AMINO ACID BLOOD LEVEL; ARTICLE; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; GENETICS; MIDDLE AGED; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HAPLOTYPES; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84919426885     PISSN: 02780240     EISSN: 18758630     Source Type: Journal    
DOI: 10.1155/2014/725731     Document Type: Article

References (29)

1. H. King, R. E. Aubert, and W. H. Herman, "Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections, " Diabetes Care, vol. 21, no. 9, pp. 1414-1431, 1998.
2. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, "Global prevalence of diabetes: estimates for the year 2000 and projections for 2030, " Diabetes Care, vol. 27, no. 5, pp. 1047-1053, 2004.
3. X. R. Pan, W. Y. Yang, G. W. Li, and J. Liu, "Prevalenceof diabetes and its risk factors in China, 1994, " Diabetes Care, vol. 20, no. 11, pp. 1664-1669, 1997.
4. W. Yang, J. Lu, J. Weng et al. , "Prevalence of diabetes amongmen and women in China, " The New England Journal of Medicine, vol. 362, no. 25, pp. 1090-1101, 2010.
5. Y. Bi, T. Wang, M. Xu et al. , "Advanced research on risk factors of type 2 diabetes, " Diabetes/Metabolism Research and Reviews, vol. 28, supplement 2, pp. 32-39, 2012.
6. S. Mao, W. Xiang, S. Huang, and A. Zhang, "Association between homocysteine status and the risk of nephropathy in type 2 diabetesmellitus, " Clinica ChimicaActa, vol. 431, pp. 206-210, 2014.
7. E. K. Hoogeveen, P. J. Kostense, P. J. Beks et al. , "Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, no. 1, pp. 133-138, 1998.
8. M. Qureshi, H. Khsandwala, I. U. Haq, and K. Prasad, "Elevated levels of plasma homocysteine in hypertensive patients with diabetes mellitus, " Journal of Cardiovascular Pharmacology and Therapeutics, vol. 8, no. 4, pp. 261-266, 2003.
9. T. Huang, J. Ren, and J. Huang, "Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach, " BMC Genomics, vol. 14, article 867, 2013.
10. M. O. Ebesunun and E. O. Obajobi, "Elevated plasma homocysteine in type 2 diabetes mellitus: a risk factor for cardiovascular diseases, " The Pan African medical journal, vol. 12, p. 48, 2012.
11. P. Frosst, H. J. Blom, R. Milos et al. , "A candidate genetic risk factor for vascular disease: a commonmutation in methylenetetrahydrofolate reductase, " Nature Genetics, vol. 10, no. 1, pp. 111-113, 1995.
12. K. Shahzad, A. Hai, A. Ahmed, N. Kizilbash, and J. Alruwaili, "A structured-based model for the decreased activity of Ala222Val and Glu429Ala Methylenetetrahydrofolate Reductase (MTHFR)mutants, " Bioinformation, vol. 9, no. 18, pp. 929-936, 2013.
13. S. C. Larsson, E. Giovannucci, and A. Wolk, "Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis, " Gastroenterology, vol. 131, no. 4, pp. 1271-1283, 2006.
14. P. Li and C. Qin, "Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to ischemic stroke: a meta-analysis, " Gene, vol. 535, no. 2, pp. 359-364, 2014.
15. B. Yang, S. Fan, and X. Zhi, "Associations of MTHFR gene polymorphisms with hypertension and hypertension in pregnancy: a meta-analysis from 114 studies with 15411 cases and 21970 controls, " PLoS ONE, vol. 9, no. 2, Article ID e87497, 2014.
16. American Diabetes Association, "Diagnosis and classification of diabetes mellitus, " Diabetes Care, vol. 33, supplement 1, pp. S62-S69, 2010.
17. J. C. Barrett, B. Fry, J. Maller, and M. J. Daly, "Haploview: analysis and visualization of LDand haplotypemaps, " Bioinformatics, vol. 21, no. 2, pp. 263-265, 2005.
18. D. Y. Lin, D. Zeug, and R. Millikan, "Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies, " Genetic Epidemiology, vol. 29, no. 4, pp. 299-312, 2005.
19. P. F. Jacques, A. G. Bostom, R. R. Williams et al. , "Relation between folate status, a commonmutation inmethylenetetrahydrofolate reductase, and plasma homocysteine concentrations, " Circulation, vol. 93, no. 1, pp. 7-9, 1996.
20. G. Friedman, N. Goldschmidt, Y. Friedlander et al. , "A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations, " Journal of Nutrition, vol. 129, no. 9, pp. 1656-1661, 1999.
21. N. R. AbdRaboh, S. Badr, and S. Ali, "Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Egyptian patients with type 2 diabetes mellitus, " Egyptian Journal of Medical Human Genetics, vol. 14, no. 1, pp. 87-93, 2013.
22. Y. Chang, W. Fu, Y. Wu, C. Yeh, C. Huang, and M. Shiau, "Prevalence ofmethylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Taiwanese patients with Type 2 diabetic mellitus, " Clinical Biochemistry, vol. 44, no. 17-18, pp. 1370-1374, 2011.
23. H. Benrahma, O. Abidi, L. Melouk et al. , "Association of the C677T polymorphism in the human methylenetetrahydrofolate reductase (MTHFR) gene with the genetic predisposition for type 2 diabetes mellitus in a Moroccan population, " Genetic Testing and Molecular Biomarkers, vol. 16, no. 5, pp. 383-387, 2012.
24. Y. Yan, H. Liang, S. Yang et al. , "Methylenetetrahydrofolate reductase A1298C polymorphism and diabetes risk: evidence from a meta-analysis, " Renal Failure, vol. 15, pp. 1-5, 2014.
25. J. Kumar, S. K. Das, P. Sharma, G. Karthikeyan, L. Ramakrishnan, and S. Sengupta, "Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population, " Journal of Human Genetics, vol. 50, no. 12, pp. 655-663, 2005.
26. S. Narayanan, J. McConnell, J. Little et al. , "Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and of measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo, " Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 9, pp. 1436-1443, 2004.
27. M. D. Swartz, C. B. Peterson, P. J. Lupo et al. , "Investigating multiple candidate genes and nutrients in the folatemetabolism pathway to detect genetic and nutritional risk factors for lung cancer, " PLoS ONE, vol. 8, no. 1, Article ID e53475, 2013.
28. A. Yoshimi, B. Aleksic, Y. Kawamura et al. , "Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data, " Schizophrenia Research, vol. 124, no. 1-3, pp. 216-222, 2010.
29. F. Marti, P. Vollenweider, P. Marques-Vidal et al. , "Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study, " BMC Public Health, vol. 11, article 733, 2011.