Association of the C677T polymorphism in the human methylenetetrahydrofolate reductase (MTHFR) gene with the genetic predisposition for type 2 diabetes mellitus in a moroccan population

Genetic Testing and Molecular Biomarkers

Volumn 16, Issue 5, 2012, Pages 383-387

  Benrahma, Houda ^a   Abidi, Omar ^a   Melouk, Leila ^a   Ajjemami, Maria ^a   Rouba, Hassan ^a   Chadli, Asmaa ^b   Oudghiri, Mounia ^c   Farouqui, Ahmed ^b   Barakat, Abdelhamid ^a  

^a Institut Pasteur du Maroc   (Morocco)

^b IBN ROCHD UNIVERSITY HOSPITAL   (Morocco)

^c Université HASSAN II   (Morocco)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; ENZYME METABOLISM; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION;

AGED; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MOROCCO; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84861518822     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2011.0179     Document Type: Article

References (35)

1. Benes P, Kanková K, Muźk J, et al. (2001) Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population. Mol Genet Metab 73:188-195.
2. Benrahma H, Arfa I, Charif M, et al. (2011) Maternal effect and familial aggregation in a type 2 diabetic Moroccan population. J Community Health. 2011 Mar 26. DOI: 10.1007/s10900-011-9393-3.
3. Boushey CJ, Beresford SAA, Omenn GS, et al. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 274:1049-1057.
4. Cugini P, Baldoni F, De Rosa R, et al. (2002) Higher blood pressure load (baric impact) in normotensives with endothelial dysfunction. a paraphysiological status of "pre-hypertension". Clin Ter 153:309-315.
5. Eroglu Z, Erdogan M, Tetik A, et al. (2007) The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy. Diabetes Metab Res Rev 23:621-624.
6. Fletcher O, Kessling AM (1998) MTHFR association with arteriosclerotic vascular disease? Hum Genet 103:11-21.
7. Frosst P, Blom HJ, Milos R, et al. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113.
8. Helfenstein T, Fonseca FA, Relvas WG, et al. (2005) Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects. Clin Chim Acta 355:165-172.
9. Internatioal Diabetes Federation (2009) Diabetes Atlas, 4th edition. www.diabetesatlas.org/map (accessed August 25, 2011).
10. Koubaa N, Nakbi A, Smaoui M, et al. (2007) Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients. Role of genetic and dietary factors. Clin Biochem 40:1007-1014.
11. Ksiazek P, Bednarek-Skublewsk A, Buraczynska M (2004) The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus. Med Sci Monit 10:BR47-51.
12. Lee SC, Pu YB, Chow CC, et al. (2000) Diabetes in Hong Kong Chinese. Evidence for familial clustering and parental effects. Diabetes Care 23:1365-1368.
13. Maeda M, Yamamoto I, Fukuda M, et al. ( 2003) MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation. Diabetes Care 26:547-548.
14. Mehri S, Koubaa N, Nakbi A, et al. ( 2010) Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients. Clin Biochem 43:259-266.
15. Moczulski D, Fojcik H, Zukowska-Szczechowska E, et al. (2003) Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy. Nephrol Dial Transplant 18:1535-1540.
16. Movva S, Alluri RV, Venkatasubramanian S, et al. (2011) Association of methylene tetrahydrofolate reductase C677T genotype with type 2 diabetes mellitus patients with and without renal complications. Genet Test Mol Biomarkers 15:257-261.
17. Ndrepepa G, Kastrati A, Braun S, et al. (2008) Circulating homocysteine levels in patients with type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 18:66-73.
18. Newman B, Selby JV, King MC, et al. (1987) Concordance for type 2 diabetes mellitus in male twins. Diabetologia 30:763-768.
19. Paluku They-They T, Hamzi K, Mazabraud A, et al. (2009) Frequency of C677T polymorphism of methylene tetrahyrofolate reductase (MTHFR) gene among Berber and Arabic Moroccan populations. Antropo 20:11-17.
20. Pepe G, Camacho Vanegas O, Giusti B, et al. (1998) Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10- methylenetetrahydrofolate reductase. Am J Hum Genet 63:917-920.
21. Permutt MA, Wasson J, Cox N (2005) Genetic epidemiology of diabetes. J Clin Invest 115:1431-1439.
22. Ralph C, Jacobsen DW (2001) Homocysteine in Health and Disease. Cambridge University Press, Cambridge, UK: 92-112.
23. Rozen R (1996) Molecular genetics of methylenetetrahydrofolate reductase deficiency. J Inher Metab Dis 19:589-594.
24. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, Vol. 3. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
25. Scott LJ, Mohlke KL, Bonnycastle LL, et al. (2007) A genomewide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345.
26. Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes. principles of pathogenesis and therapy. Lancet 365: 1333-1346.
27. Sun J, Xu Y, Xue J, Zhu Y, Lu H (2005) Methylenetetrahydrofolate reductase polymorphism associated with susceptibility to coronary heart disease in Chinese type 2 diabetic patients. Mol Cell Endocrinol 229:95-101.
28. Sun J, Xu Y, Zhu Y, et al. (2004) Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients. Diabetes Res Clin Pract 64:185-190.
29. Szczeklik A, Sanak M, Jankowski M, et al. (2001) Mutation A1298C of methylenetetrahydrofolate reductase. risk for early coronary disease not associated with hyperhomocysteinemia. Am J Med Genet 101:36-39.
30. Van der Put NM, Gabreëls F, Stevens EM, et al. (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62:1044-1051.
31. Weisberg I, Tran P, Christensen B, et al. (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Gen Methab 64:169-172.
32. Weisberg IS, Jacques PF, Selhub J, et al. (2001) The 1298A-> C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156:409-415.
33. Wild S, Roglic G, Green A, et al. (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-1053.
34. Yoshioka K, Yoshida T, Umekawa T, et al. (2004) Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese Type 2 diabetic patients. Diabet Med 21:1051-1052.
35. Zeggini E, Scott LJ, Saxena R, et al. (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645.