메뉴 건너뛰기




Volumn 55, Issue 12, 2014, Pages 2691-2698

Prognostic significance of Tet methylcytosine dioxygenase 2 (TET2) gene mutations in adult patients with acute myeloid leukemia: A meta-analysis

Author keywords

Acute myeloid leukemia; Meta analysis; Mutation; Prognosis; TET2

Indexed keywords

DIOXYGENASE; HEMOGLOBIN; TET METHYLCYTOSINE DIOXYGENASE 2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

EID: 84919414970     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2014.893308     Document Type: Review
Times cited : (44)

References (52)
  • 1
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
    • Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011;29:475-486.
    • (2011) J Clin Oncol , vol.29 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Dohner, H.3
  • 2
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study
    • Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood 2000;96:4075-4083.
    • (2000) Blood , vol.96 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 3
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010;115:453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3
  • 4
    • 77955914238 scopus 로고    scopus 로고
    • Ref nement of cytogenetic classif cation in acute myeloid leukemia: Determination of prognostic signif cance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials
    • Grimwade D, Hills RK, Moorman AV, et al. Ref nement of cytogenetic classif cation in acute myeloid leukemia: determination of prognostic signif cance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood 2010; 116: 354-365.
    • (2010) Blood , vol.116 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3
  • 5
    • 77956925717 scopus 로고    scopus 로고
    • WHO classif cation of tumours of haematopoietic and lymphoid tissues in 2008: An overview
    • Sabattini E, Bacci F, Sagramoso C, et al. WHO classif cation of tumours of haematopoietic and lymphoid tissues in 2008: an overview. Pathologica 2010; 102: 83-87.
    • (2010) Pathologica , vol.102 , pp. 83-87
    • Sabattini, E.1    Bacci, F.2    Sagramoso, C.3
  • 6
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008;358:1909-1918.
    • (2008) N Engl J Med , vol.358 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 7
    • 84866378702 scopus 로고    scopus 로고
    • The role of mutations in epigenetic regulators in myeloid malignancies
    • Shih AH, Abdel-Wahab O, Patel JP, et al. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer 2012;12:599-612.
    • (2012) Nat Rev Cancer , vol.12 , pp. 599-612
    • Shih, A.H.1    Abdel-Wahab, O.2    Patel, J.P.3
  • 8
    • 83055161507 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
    • Grossmann V, Tiacci E, Holmes AB, et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 2011;118:6153-6163.
    • (2011) Blood , vol.118 , pp. 6153-6163
    • Grossmann, V.1    Tiacci, E.2    Holmes, A.B.3
  • 9
    • 78549279199 scopus 로고    scopus 로고
    • Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comblike 1 (ASXL1) mutations
    • Chou WC, Huang HH, Hou HA, et al. Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comblike 1 (ASXL1) mutations. Blood 2010;116:4086-4094.
    • (2010) Blood , vol.116 , pp. 4086-4094
    • Chou, W.C.1    Huang, H.H.2    Hou, H.A.3
  • 10
    • 82155183257 scopus 로고    scopus 로고
    • Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia
    • Li M, Collins R, Jiao Y, et al. Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia. Blood 2011;118:5914-5917.
    • (2011) Blood , vol.118 , pp. 5914-5917
    • Li, M.1    Collins, R.2    Jiao, Y.3
  • 11
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic prof ling in acute myeloid leukemia
    • Patel JP, Gonen M, Figueroa ME, et al. Prognostic relevance of integrated genetic prof ling in acute myeloid leukemia. N Engl J Med 2012;366:1079-1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3
  • 12
    • 84868342138 scopus 로고    scopus 로고
    • Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: A meta-analysis
    • Zhou KG, Jiang LJ, Shang Z, et al. Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis. Leuk Lymphoma 2012; 53:2423-2429.
    • (2012) Leuk Lymphoma , vol.53 , pp. 2423-2429
    • Zhou, K.G.1    Jiang, L.J.2    Shang, Z.3
  • 13
    • 84886804684 scopus 로고    scopus 로고
    • DNMT3A mutation is a poor prognosis biomarker in AML: Results of a meta-analysis of 4500 AML patients
    • Shivarov V, Gueorguieva R, Stoimenov A, et al. DNMT3A mutation is a poor prognosis biomarker in AML: Results of a meta-analysis of 4500 AML patients. Leuk Res 2013; 37: 1445-1450.
    • (2013) Leuk Res , vol.37 , pp. 1445-1450
    • Shivarov, V.1    Gueorguieva, R.2    Stoimenov, A.3
  • 14
    • 84894232507 scopus 로고    scopus 로고
    • Prognostic signif cance of IDH1 mutations in acute myeloid leukemia: A meta-analysis
    • Feng JH, Guo XP, Chen YY, et al. Prognostic signif cance of IDH1 mutations in acute myeloid leukemia: a meta-analysis. Am J Blood Res 2012;2:254-264.
    • (2012) Am J Blood Res , vol.2 , pp. 254-264
    • Feng, J.H.1    Guo, X.P.2    Chen, Y.Y.3
  • 15
    • 79960229916 scopus 로고    scopus 로고
    • Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
    • Itzykson R, Kosmider O, Cluzeau T, et al. Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia 2011; 25: 1147-1152.
    • (2011) Leukemia , vol.25 , pp. 1147-1152
    • Itzykson, R.1    Kosmider, O.2    Cluzeau, T.3
  • 16
    • 80052285127 scopus 로고    scopus 로고
    • Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
    • Li Z, Cai X, Cai CL, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 2011;118:4509-4518.
    • (2011) Blood , vol.118 , pp. 4509-4518
    • Li, Z.1    Cai, X.2    Cai, C.L.3
  • 17
    • 84901457444 scopus 로고    scopus 로고
    • Mutation selective IDH inhibitors mediate histone and DNA methylation changes
    • Yen K, Wang F, Schalm S, et al. Mutation selective IDH inhibitors mediate histone and DNA methylation changes. Blood 2012; 120 (Suppl. 1): Abstract 3509.
    • (2012) Blood , vol.120 , pp. 3509
    • Yen, K.1    Wang, F.2    Schalm, S.3
  • 18
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber J, Shi J, Wang E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011; 478: 524-528.
    • (2011) Nature , vol.478 , pp. 524-528
    • Zuber, J.1    Shi, J.2    Wang, E.3
  • 19
    • 80054984945 scopus 로고    scopus 로고
    • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
    • Dawson MA, Prinjha RK, Dittmann A, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 2011;478:529-533.
    • (2011) Nature , vol.478 , pp. 529-533
    • Dawson, M.A.1    Prinjha, R.K.2    Dittmann, A.3
  • 20
    • 67649876132 scopus 로고    scopus 로고
    • Acquired mutations in TET2 are common in myelodysplastic syndromes
    • Langemeijer SM, Kuiper RP, Berends M, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 2009;41:838-842.
    • (2009) Nat Genet , vol.41 , pp. 838-842
    • Langemeijer, S.M.1    Kuiper, R.P.2    Berends, M.3
  • 21
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He YF, Li BZ, Li Z, et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011;333:1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3
  • 22
    • 70149101696 scopus 로고    scopus 로고
    • Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms
    • Saint-Martin C, Leroy G, Delhommeau F, et al. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Blood 2009;114:1628-1632.
    • (2009) Blood , vol.114 , pp. 1628-1632
    • Saint-Martin, C.1    Leroy, G.2    Delhommeau, F.3
  • 23
    • 77953753005 scopus 로고    scopus 로고
    • New TET2 gene mutations in patients with myeloproliferative neoplasms and splanchnic vein thrombosis
    • Colaizzo D, Tiscia GL, Pisanelli D, et al. New TET2 gene mutations in patients with myeloproliferative neoplasms and splanchnic vein thrombosis. J T romb Haemost 2010; 8: 1142-1144.
    • (2010) J T Romb Haemost , vol.8 , pp. 1142-1144
    • Colaizzo, D.1    Tiscia, G.L.2    Pisanelli, D.3
  • 24
    • 77953616961 scopus 로고    scopus 로고
    • Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations
    • Szpurka H, Jankowska AM, Makishima H, et al. Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations. Leuk Res 2010;34:969-973.
    • (2010) Leuk Res , vol.34 , pp. 969-973
    • Szpurka, H.1    Jankowska, A.M.2    Makishima, H.3
  • 25
    • 77955081371 scopus 로고    scopus 로고
    • Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias
    • Rocquain J, Carbuccia N, Trouplin V, et al. Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. BMC Cancer 2010;10:401.
    • (2010) BMC Cancer , vol.10 , pp. 401
    • Rocquain, J.1    Carbuccia, N.2    Trouplin, V.3
  • 26
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010;468:839-843.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3
  • 27
    • 84861389471 scopus 로고    scopus 로고
    • A meta-analysis of TET2 mutations shows a distinct distribution pattern in de novo acute myeloid leukemia and chronic myelomonocytic leukemia
    • Euba B, Vizmanos JL, Garcia-Granero M, et al. A meta-analysis of TET2 mutations shows a distinct distribution pattern in de novo acute myeloid leukemia and chronic myelomonocytic leukemia. Leuk Lymphoma 2012; 53: 1230-1233.
    • (2012) Leuk Lymphoma , vol.53 , pp. 1230-1233
    • Euba, B.1    Vizmanos, J.L.2    Garcia-Granero, M.3
  • 29
    • 84860703461 scopus 로고    scopus 로고
    • Landscape of TET2 mutations in acute myeloid leukemia
    • Weissmann S, Alpermann T, Grossmann V, et al. Landscape of TET2 mutations in acute myeloid leukemia. Leukemia 2012; 26: 934-942.
    • (2012) Leukemia , vol.26 , pp. 934-942
    • Weissmann, S.1    Alpermann, T.2    Grossmann, V.3
  • 30
    • 84862266735 scopus 로고    scopus 로고
    • TET2 mutations in acute myeloid leukemia (AML): Results from a comprehensive genetic and clinical analysis of the AML study group
    • Gaidzik VI, Paschka P, Spath D, et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin Oncol 2012; 30: 1350-1357.
    • (2012) J Clin Oncol , vol.30 , pp. 1350-1357
    • Gaidzik, V.I.1    Paschka, P.2    Spath, D.3
  • 31
    • 84861208252 scopus 로고    scopus 로고
    • The incidence of TET2 gene mutation and its clinical signif cance in acute myeloid leukemia patients
    • Wei JF, Chen GH, Qiu HY, et al. The incidence of TET2 gene mutation and its clinical signif cance in acute myeloid leukemia patients. Zhonghua Xue Ye Xue Za Zhi 2011; 32: 304-307.
    • (2011) Zhonghua Xue Ye Xue Za Zhi , vol.32 , pp. 304-307
    • Wei, J.F.1    Chen, G.H.2    Qiu, H.Y.3
  • 32
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European LeukemiaNet risk classif cation of acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Metzeler KH, Maharry K, Radmacher MD, et al. TET2 mutations improve the new European LeukemiaNet risk classif cation of acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2011;29:1373-1381.
    • (2011) J Clin Oncol , vol.29 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3
  • 33
    • 79959952948 scopus 로고    scopus 로고
    • TET2 mutations in secondary acute myeloid leukemias: A French retrospective study
    • Kosmider O, Delabesse E, Mansat-De Mas V, et al. TET2 mutations in secondary acute myeloid leukemias: a French retrospective study. Haematologica 2011; 96: 1059-1063.
    • (2011) Haematologica , vol.96 , pp. 1059-1063
    • Kosmider, O.1    Delabesse, E.2    Mansat-De Mas, V.3
  • 34
    • 80053620171 scopus 로고    scopus 로고
    • TET2mutationisanunfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
    • Chou WC, Chou SC, Liu CY, et al. TET2mutationisanunfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood 2011;118:3803-3810.
    • (2011) Blood , vol.118 , pp. 3803-3810
    • Chou, W.C.1    Chou, S.C.2    Liu, C.Y.3
  • 35
    • 77956513784 scopus 로고    scopus 로고
    • Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission
    • Nibourel O, Kosmider O, Cheok M, et al. Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission. Blood 2010;116:1132-1135.
    • (2010) Blood , vol.116 , pp. 1132-1135
    • Nibourel, O.1    Kosmider, O.2    Cheok, M.3
  • 36
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009;114:144-147.
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3
  • 38
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998;17:2815-2834.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 39
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560.
    • (2003) BMJ , vol.327 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3
  • 41
    • 0030693603 scopus 로고    scopus 로고
    • Quantitative synthesis in systematic reviews
    • Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med 1997;127:820-826.
    • (1997) Ann Intern Med , vol.127 , pp. 820-826
    • Lau, J.1    Ioannidis, J.P.2    Schmid, C.H.3
  • 42
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 43
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3
  • 44
    • 70350438115 scopus 로고    scopus 로고
    • TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
    • Kosmider O, Gelsi-Boyer V, Cheok M, et al. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood 2009;114:3285-3291.
    • (2009) Blood , vol.114 , pp. 3285-3291
    • Kosmider, O.1    Gelsi-Boyer, V.2    Cheok, M.3
  • 45
    • 67650924270 scopus 로고    scopus 로고
    • Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
    • Theferi A, Lim KH, Abdel-Wahab O, et al. Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia 2009; 23: 1343-1345.
    • (2009) Leukemia , vol.23 , pp. 1343-1345
    • Theferi, A.1    Lim, K.H.2    Abdel-Wahab, O.3
  • 46
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofbrosis
    • Theferi A, Pardanani A, Lim KH, et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofbrosis. Leukemia 2009; 23: 905-911.
    • (2009) Leukemia , vol.23 , pp. 905-911
    • Theferi, A.1    Pardanani, A.2    Lim, K.H.3
  • 47
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classifcation?
    • Mrozek K, Marcucci G, Paschka P, et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classifcation? Blood 2007;109:431-448.
    • (2007) Blood , vol.109 , pp. 431-448
    • Mrozek, K.1    Marcucci, G.2    Paschka, P.3
  • 48
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Dohner K, Schlenk RF, Habdank M, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood 2005;106:3740-3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 49
    • 77449140390 scopus 로고    scopus 로고
    • Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene-and microRNA-expression signatures: A Cancer and Leukemia Group B study
    • Becker H, Marcucci G, Maharry K, et al. Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene-and microRNA-expression signatures: a Cancer and Leukemia Group B study. J Clin Oncol 2010;28:596-604.
    • (2010) J Clin Oncol , vol.28 , pp. 596-604
    • Becker, H.1    Marcucci, G.2    Maharry, K.3
  • 50
    • 55549103713 scopus 로고    scopus 로고
    • Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: A Cancer and Leukemia Group B Study
    • Marcucci G, Maharry K, Radmacher MD, et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol 2008;26:5078-5087.
    • (2008) J Clin Oncol , vol.26 , pp. 5078-5087
    • Marcucci, G.1    Maharry, K.2    Radmacher, M.D.3
  • 51
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010;28:2348-2355.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 52
    • 80052924863 scopus 로고    scopus 로고
    • Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors
    • Pollyea DA, Raval A, Kusler B, et al. Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors. Hematol Oncol 2011;29: 157-160.
    • (2011) Hematol Oncol , vol.29 , pp. 157-160
    • Pollyea, D.A.1    Raval, A.2    Kusler, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.