Distinguishing nested variants of urothelial carcinoma from benign mimickers by TERT promoter mutation

American Journal of Surgical Pathology

Volumn 39, Issue 1, 2015, Pages 127-131

  Zhong, Minghao ^a   Tian, Wei ^b   Zhuge, Jian ^a   Zheng, Xiaoyong ^a   Huang, Tiangui ^a   Cai, Dongming ^b   Zhang, David ^c   Yang, Ximing J ^d   Argani, Pedram ^b   Fallon, John T ^a   Epstein, Jonathan I ^e  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI MEDICAL CENTER   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Benign mimickers; Nested variants of urothelial carcinoma; TERT promoter mutation

Indexed keywords

TELOMERASE; TERT PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; BIOPSY; CARCINOMA; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; GENETICS; HUMAN; MALE; MIDDLE AGED; MULTICENTER STUDY; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PILOT STUDY; PREDICTIVE VALUE; PROMOTER REGION; UNITED STATES; UROGENITAL TRACT TUMOR; UROTHELIUM; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BALTIMORE; BIOPSY; CARCINOMA; DIAGNOSIS, DIFFERENTIAL; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; NEW YORK; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; PROMOTER REGIONS, GENETIC; TELOMERASE; TUMOR MARKERS, BIOLOGICAL; UROGENITAL NEOPLASMS; UROTHELIUM;

EID: 84919400533     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000305     Document Type: Article

References (19)

1. Murphy WM, Deana DG. The nested variant of transitional cell carcinoma: a neoplasm resembling proliferation of Brunns nests. Mod Pathol. 1992;5:240-243.
2. Stern JB. Unusual benign bladder tumor of Brunn nest origin. Urology. 1979;14:288-289.
3. Talbert ML, Young RH. Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. Am J Surg Pathol. 1989;13:374-381.
4. Lin O, Cardillo M, Dalbagni G, et al. Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. Mod Pathol. 2003;16:1289-1298.
5. Volmar KE, Chan TY, De Marzo AM, et al. Florid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma. Am J Surg Pathol. 2003;27:1243-1252.
6. Cox R, Epstein JI. Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. Am J Surg Pathol. 2011; 35:1337-1342.
7. Horn S, Figl A, Rachakonda PS, et al. TERT promoter mutations in familial and sporadic melanoma. Science. 2013;339:959-961.
8. Huang FW, Hodis E, Xu MJ, et al. Highly recurrent TERT promoter mutations in human melanoma. Science. 2013;339: 957-959.
9. Killela PJ, Reitman ZJ, Jiao Y, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci USA. 2013; 110:6021-6026.
10. Liu X, Wu G, Shan Y, et al. Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma. Cell Cycle. 2013;12: 1637-1638.
11. Vinagre J, Almeida A, Populo H, et al. Frequency of TERT promoter mutations in human cancers. Nat Commun. 2013;4: 2185-2190.
12. Wu S, Huang P, Li C, et al. Telomerase reverse transcriptase gene promoter mutations help discern the origin of urogenital tumors: a genomic and molecular study. Eur Urol. 2014;65:274-277.
13. Kinde I, Munari E, Faraj SF, et al. TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine. Cancer Res. 2013;73: 7162-7167.
14. Hurst CD, Platt FM, Knowles MA. Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine. Eur Urol. 2014;65:367-369.
15. Allory Y, Beukers W, Sagrera A, et al. Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome. Eur Urol. 2014;65:360-366.
16. Linder BJ, Frank I, Cheville JC, et al. Outcomes following radical cystectomy for nested variant of urothelial carcinoma: a matched cohort analysis. J Urol. 2013;189:1670-1675.
17. Drew PA, Furman J, Civantos F, et al. The nested variant of transitional cell carcinoma: an aggressive neoplasm with innocuous histology. Mod Pathol. 1996;9:989-994.
18. Holmang S, Johansson SL. The nested variant of transitional cell carcinoma-a rare neoplasm with poor prognosis. Scand J Urol Nephrol. 2001;35:102-105.
19. Cardillo M, Reuter VE, Lin O. Cytologic features of the nested variant of urothelial carcinoma: a study of seven cases. Cancer. 2003;99:23-27.