Serum ghrelin levels partially recover with the recovery of appetite and food intake after total gastrectomy

Surgery Today

Volumn 44, Issue 11, 2014, Pages 2131-2137

  Koizumi, Masaru ^a   Hosoya, Yoshinori ^a   Dezaki, Katsuya ^a   Yada, Toshihiko ^a   Hosoda, Hiroshi ^b   Kangawa, Kenji ^b   Nagai, Hideo ^a,c   Lefor, Alan T ^a   Sata, Naohiro ^a   Yasuda, Yoshikazu ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c IBARAKI PREFECTURAL CENTRAL HOSPITAL   (Japan)

Author keywords

Gastrectomy; Ghrelin; Weight loss

Indexed keywords

ANTINEOPLASTIC AGENT; GHRELIN; SERUM ALBUMIN;

ADULT; AGED; ALBUMIN BLOOD LEVEL; APPETITE; ARTICLE; BODY MASS; CANCER ADJUVANT THERAPY; CANCER CLASSIFICATION; CANCER PATIENT; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CLINICAL ARTICLE; DUMPING SYNDROME; FEMALE; FOOD INTAKE; HORMONE BLOOD LEVEL; HUMAN; LYMPH NODE DISSECTION; MALE; NUTRITIONAL STATUS; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; QUESTIONNAIRE; STOMACH CARCINOMA; TOTAL STOMACH RESECTION; WEIGHT REDUCTION; BLOOD; CONVALESCENCE; EATING; GASTRECTOMY; GENETICS; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PERIOPERATIVE PERIOD; PHYSIOLOGY; STOMACH NEOPLASMS; TIME; WEIGHT GAIN;

AGED; APPETITE; EATING; FEMALE; GASTRECTOMY; GHRELIN; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PERIOPERATIVE PERIOD; PROSPECTIVE STUDIES; QUESTIONNAIRES; RECOVERY OF FUNCTION; STOMACH NEOPLASMS; TIME FACTORS; WEIGHT GAIN; WEIGHT LOSS;

EID: 84919386306     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-014-0873-9     Document Type: Article

References (31)

1. Bae JM, Park JW, Yang HK, Kim JP. Nutritional status of gastric cancer patients after total gastrectomy. World J Surg. 1998;22:254–60.
2. Melissas J, Kampitakis E, Schoretsanitis G, Mouzas J, Kouromalis E, Tsiftsis DD. Does reduction in gastric acid secretion in bariatric surgery increase diet-induced thermogenesis? Obes Surg. 2002;12:399–403.
3. Adachi S, Takeda T, Fukao K. Evaluation of esophageal bile reflux after total gastrectomy by gastrointestinal and hepatobiliary dual scintigraphy. Surg Today. 1999;29:301–6.
4. Iesato H, Ohya T, Ohwada S, Itagaki S, Yokomori T, Morishita Y. Jejunal pouch interposition with an antiperistaltic conduit as a pyloric ring substitute after standard distal gastrectomy: a comparison with the use of an isoperistaltic conduit. Hepatogastroenterology. 2000;47:756–60.
5. Braga M, Zuliani W, Foppa L, DiCarlo V, Cristallo M. Food intake and nutritional status after total gastrectomy: results of a nutritional follow-up. Br J Surg. 1988;75:477–80.
6. Bergh C, Sjostedt S, Hellers G, Zandian M, Sodersten P. Meal size, satiety and cholecystokinin in gastrectomized humans. Physiol Behav. 2003;78:143–7.
7. Fein M, Fuchs KH, Thalheimer A, Freys SM, Heimbucher J, Thiede A. Long-term benefits of Roux-en-Y pouch reconstruction after total gastrectomy: a randomized trial. Ann Surg. 2008;247:759–65.
8. Yamashita K, Sakuramoto S, Shibata T, Nemoto M, Mieno H, Katada N, Kikuchi S, Watanabe M. Survival outcome of laparoscopic gastrectomy for early (cT1) gastric cancer. Surg Today. 2013;43:1013–8.
9. Liedman B. Symptoms after total gastrectomy on food intake, body composition, bone metabolism, and quality of life in gastric cancer patients: is reconstruction with a reservoir worthwhile? Nutrition. 1999;15:677–82.
10. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–60.
11. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes. 2001;50:227–32.
12. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka X, Itoh Z, et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun. 2000;276:905–8.
13. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondai MS, Sugunuma T, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000;141:4255–61.
14. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346:1623–30.
15. Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem. 2003;278:64–70.
16. Leonetti F, Silecchia G, Iacobellis G, Ribaudo MC, Zappaterrano A, Tiberti C, et al. Different plasma ghrelin levels after laparoscopic gastric bypass and adjustable gastric banding in morbid obese subjects. J Clin Endocrinol Metab. 2003;88:4227–31.
17. Doki Y, Takachi K, Ishikawa O, Miyashiro I, Sasaki Y, Ohigashi H, et al. Ghrelin reduction after esophageal substitution and its correlation to postoperative body weight loss in esophageal cancer patients. Surgery. 2006;139:797–805.
18. Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun. 2000;279:909–13.
19. Takachi K, Doki Y, Ishikawa O, Miyashiro I, Sasaki Y, Ohigashi H, et al. Postoperative ghrelin levels and delayed recovery from body weight loss after distal or total gastrectomy. J Surg Res. 2006;130:1–7.
20. Jeon TY, Lee S, Kim HH, Kim YJ, Son HC, Kim DH, et al. Changes in plasma ghrelin concentration immediately after gastrectomy in patients with early gastric cancer. J Clin Endocrinol Metab. 2004;89:5392–6.
21. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001;120:337–45.
22. Date Y, Murakami N, Toshinai K, Matsukura S, Nijima A, Matsuo H, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology. 2002;123:1120–8.
23. Williams DL, Grill HJ, Cummings DE, Kaplan JM. Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology. 2003;144:5184–7.
24. Nakamura M, Kido Y, Yano M, Hosoya Y. Reliability and validity of a new scale to assess postoperative dysfunction after resection of upper gastrointestinal carcinoma. Surg Today. 2005;35:535–42.
25. Nakamura M, Hosoya Y, Yano M, Doki Y, Miyashiro I, Kurashina K, et al. Extent of gastric resection impacts patient quality of life: the dysfunction after upper gastrointestinal surgery for cancer (DAUGS32) scoring system. Ann Surg Oncol. 2011;18:314–20.
26. Neary NM, Small CJ, Wren AM, Lee JL, Druce WR, Palmieri C, et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab. 2004;89:2832–6.
27. le Roux CW, Neary NM, Halsey TJ, Small CJ, Martinez-Isla AM, Ghatei MA, et al. Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrinol Metab. 2005;90:4521–4.
28. Koizumi M, Hosoya Y, Dezaki K, Yada T, Hosoda H, Kangawa K, et al. Postoperative weight loss does not resolve after esophagectomy despite normal serum ghrelin levels. Ann Thor Surg. 2011;91:1032–8.
29. Yamamoto K, Takiguchi S, Miyata H, Adachi S, Hiura Y, Yamasaki M, et al. Randomized phase II study of clinical effects of ghrelin after esophagectomy with gastric tube resection. Surgery. 2010;148:31–8.
30. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86:5992.
31. Nagaya N, Miyatake K, Uematsu M, Oya H, Shimizu W, Hosoda H, et al. Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure. J Clin Endocrinol Metab. 2001;86:5854–9.