Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 50, 2014, Pages 18078-18083

  Hondares, Elayne ^a   Brown, Mark Adrian ^a   Musset, Boris ^b   Morgan, Deri ^c   Cherny, Vladimir V ^c   Taubert, Christina ^a,f   Bhamrah, Mandeep K ^d,g   Coe, David ^a   Marelli Berg, Federica ^a   Gribben, John G ^a   Dyer, Martin J S ^e   Decoursey, Thomas E ^c   Capasso, Melania ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c RUSH MEDICAL COLLEGE   (United States)

^d MRC TOXICOLOGY UNIT   (United Kingdom)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

^f NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^g Cancer Research Technology   (United Kingdom)

Author keywords

Chronic lymphocytic leukemia; Gating kinetics; Hv1; Phosphorylation; Proton currents

Indexed keywords

B LYMPHOCYTE RECEPTOR; CATION CHANNEL; HYDROGEN VOLTAGE GATED CHANNEL 1; ISOPROTEIN; PROTEIN KINASE C; PROTON; THREONINE; UNCLASSIFIED DRUG; HV1 CHANNEL, HUMAN; ION CHANNEL; REACTIVE OXYGEN METABOLITE;

ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; B-CELL LYMPHOMA CELL LINE; CELL MIGRATION; CELL PROLIFERATION; CHANNEL GATING; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; COMPARATIVE STUDY; GENETICS; HEK293 CELL LINE; HEMATOLOGIC DISEASE; IMMUNOLOGY; METABOLISM; MOUSE; PATCH CLAMP TECHNIQUE; PHOSPHORYLATION; TUMOR CELL LINE;

MAMMALIA;

ANIMALS; B-LYMPHOCYTES; CELL LINE, TUMOR; HEK293 CELLS; HEMATOLOGIC NEOPLASMS; HUMANS; ION CHANNELS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES;

EID: 84919360914     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411390111     Document Type: Article

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