Regulatory Mechanisms and Physiological Relevance of a Voltage-Gated H + Channel in Murine Osteoclasts: Phorbol Myristate Acetate Induces Cell Acidosis and the Channel Activation

Journal of Bone and Mineral Research

Volumn 18, Issue 11, 2003, Pages 2069-2076

  Mori, Hiroyuki ^a   Sakai, Hiromu ^a   Morihata, Hirokazu ^a   Kawawaki, Junko ^a   Amano, Hitoshi ^b   Yamano, Tsunekazu ^a   Kuno, Miyuki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Cell acidosis; Osteoclast; pH homeostasis; Phorbol ester; Proton channel

Indexed keywords

COLONY STIMULATING FACTOR 1; ION CHANNEL; OSTEOCLAST DIFFERENTIATION FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM ION; PROTON; PROTON PUMP;

ACIDIFICATION; ACIDOSIS; ALKALINITY; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PH; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; FLUORESCENCE; HOMEOSTASIS; ION CURRENT; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PH MEASUREMENT; REGULATORY MECHANISM; VOLTAGE GATED PROTON CHANNEL;

ACIDOSIS; ANIMALS; ELECTRIC CONDUCTIVITY; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; ION CHANNELS; MALE; MEMBRANE POTENTIALS; MICE; OSTEOCLASTS; PATCH-CLAMP TECHNIQUES; PROTONS; TETRADECANOYLPHORBOL ACETATE;

EID: 0242412921     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.11.2069     Document Type: Article

References (39)

1. Rousselle AV, Heymann D 2002 Osteoclastic acidification pathways during bone resorption. Bone 30:533-540.
2. Kapus A, Romanek R, Qu AY, Rotstein OD, Grinstein S 1993 A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages. J Gen Physiol 102:729-760.
3. Holevinsky KO, Jow F, Nelson DJ 1994 Elevation in intracellular calcium activates both chloride and proton currents in human macrophages. J Membr Biol 140:13-30.
4. Eder C, Fischer H-G, Hadding U, Heinemann U 1995 Properties of voltage-gated currents of microglia developed using macrophage colony-stimulating factor. Pflugers Arch 430:526-533.
5. Morihata H, Nakamura F, Tsutada T, Kuno M 2000 Potentiation of a voltage-gated proton current in acidosis-induced swelling of rat microglia. J Neurosci 20:7220-7227.
6. Nordström T, Rotstein OD, Romanek R, Asotra S, Heersche JN, Manolson MF, Brisseau GF, Grinstein S 1995 Regulation of cytoplasmic pH in osteoclasts. Contribution of proton pumps and a proton-selective conductance. J Biol Chem 270:2203-2212.
7. + channel is a powerful mechanism for pH homeostasis in murine osteoclasts. Kobe J Med Sci 48:87-96.
8. DeCoursey TE 2003 Voltage-gated proton channels and other proton transfer pathways. Physiol Rev 83:475-579.
9. + channel involved in the respiratory burst. J Gen Physiol 120:757.
10. Kuno M, Kawawaki J, Nakamura F 1997 A highly temperature-sensitive proton current in mouse bone marrow-derived mast cells. J Gen Physiol 109:731-740.
11. + currents in human neutrophils, rat alveolar epithelial cells, and mammalian phagocytes. J Gen Physiol 112:503-522.
12. + channel. Biochem J 246:325-329.
13. Schrenzel J, Serrander L, Bánfi B, Nüsse O, Fouyouzi R, Lew DP, Demaurex N, Krause KH 1998 Electron currents generated by the human phagocyte NADPH oxidase. Nature 392:734-737.
14. DeCoursey TE, Cherny VV, Zhou W, Thomas LL 2000 Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils. Proc Natl Acad Sci USA 97:6885-6889.
15. + (equivalent) conductance in the plasma membrane of human neutrophils. Proc Natl Acad Sci USA 88:10816-10820.
16. +-conducting pathway in the membrane of neutrophils. Biochem J 281:697-701.
17. DeCoursey TE, Cherny VV, DeCoursey AG, Xu W, Thomas LL 2001 Interactions between NADPH oxidase-related proton and electron currents in human eosinophils. J Physiol 535:767-781.
18. Lorenzo JA, Sousa S 1988 Phorbol esters stimulate bone resorption in fetal rat long-bone culture by mechanisms independent of prostaglandin synthesis. J Bone Miner Res 3:63-67.
19. o-sensing in cultured osteoclasts. Am J Physiol 263:C130-C139.
20. Williams JP, McKenna MA, Thames AM III, McDonald JM 2000 Tamoxifen inhibits phorbol ester stimulated osteoclastic bone resorption: An effect mediated by calmodulin. Biochem Cell Biol 78:715-723.
21. Zhang ZY, Mühlbauer R, Felix R 1998 Phorbol myristate acetate downregulates the binding sites for colony-stimulating factor-1 on osteoclasts isolated form rats. Calcif Tissue Int 62:148-152.
22. Mori H, Sakai H, Morihata H, Sakuta K, Kuno M 2001 A voltage-gated proton channel in murine osteoclasts during development from bone marrow cells. J Bone Miner Res 16:S1;S377.
23. Niida S, Kaku M, Amano H, Yoshida H, Kataoka H, Nishikawa S, Tanne K, Maeda N, Nishikawa S, Kodama H 1999 Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med 190:293-298.
24. Suzuki K, Zhu B, Rittling SR, Denhardt DT, Goldberg HA, McCulloch CA, Sodek J 2002 Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J Bone Miner Res 17:1486-1497.
25. - conductances in murine osteoclasts. J Membr Biol 158:59-67.
26. Morihata H, Kawawaki J, Sakai H, Sawada M, Tsutada T, Kuno M 2000 Temporal fluctuation of voltage-gated proton currents in rat spinal microglia via pH-dependent and -independent mechanisms. Neurosci Res 38:265-271.
27. Gordienko DV, Tare M, Parveen S, Fenech CJ, Robinson C, Bolton TB 1996 Voltage-activated proton current in eosinophils from human blood. J Physiol 496:299-316.
28. i in large (≥10 nuclei) and small (≤5 nuclei) osteoclasts. Am J Physiol 279:C751-C761.
29. Steinbeck MJ, Appel WH Jr, Verhoeven AJ, Karnovsky MJ 1994 NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone. J Cell Biol 126:765-772.
30. Darden AG, Ries WL, Wolf WC, Rodriguiz RM, Key LL Jr 1996 Osteoclastic superoxide production and bone resorption: Stimulation and inhibition by modulators of NADPH oxidase. J Bone Miner Res 11:671-675.
31. + conducting channel. Biochem J 251:563-567.
32. 2+ in murine osteoclasts. J Physiol 515:157-168.
33. - channel in extracellular calcium-sensing of murine osteoclasts. Osaka City Med J 48:29-38.
34. Samura A, Wada S, Suda S, Iitaka M, Katayama S 2000 Calcitonin receptor regulation and responsiveness to calcitonin in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappa B ligand and macrophage colony stimulating factor. Endocrinology 141:3774-3782.
35. Su Y, Chakraborty M, Nathanson MH, Baron R 1992 Differential effects of the 3′, 5′-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin. Endocrinology 131:1497-1502.
36. 2+-sensing receptor (CaR) activates phospholipase C, A2, D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells. J Bone Miner Res 12:715-725.
37. 2+-sensing is modulated by pH in human osteoclast-like cells in vitro. Am J Physiol 267:C961-C968.
38. - channel in murine osteoclasts. Bone 31:374-380.
39. Shanker VS, Huang CLH, Adebanjo O, Simon B, Alam ASMT, Moonga BS, Pazianas M, Scott RH, Zaidi M 1995 Effect of membrane potential on surface receptor activation in rat osteoclasts. J Cell Physiol 162:1-8.