Thoracic epithelioid malignant vascular tumors: A clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions

American Journal of Surgical Pathology

Volumn 39, Issue 1, 2015, Pages 132-139

  Anderson, Todd ^a   Zhang, Lei ^a   Hameed, Meera ^a   Rusch, Valerie ^a   Travis, William D ^a   Antonescu, Cristina R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Angiosarcoma; CAMTA1; Epithelioid hemangioendothelioma; Prognosis; Thoracic; WWTR1

Indexed keywords

CALCIUM BINDING PROTEIN; CAMTA1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TRANSACTIVATOR PROTEIN; TUMOR MARKER; WWTR1 PROTEIN, HUMAN;

ADULT; AGED; BIOPSY; CANCER GRADING; CELL PROLIFERATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; GENETICS; HEMANGIOENDOTHELIOMA, EPITHELIOID; HEMANGIOSARCOMA; HUMAN; KAPLAN MEIER METHOD; MALE; MIDDLE AGED; MITOSIS INDEX; MORTALITY; NECROSIS; PATHOLOGY; PREDICTIVE VALUE; THORACIC NEOPLASMS; TIME FACTOR; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; BIOPSY; CALCIUM-BINDING PROTEINS; CELL PROLIFERATION; FEMALE; GENE FUSION; HEMANGIOENDOTHELIOMA, EPITHELIOID; HEMANGIOSARCOMA; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MITOTIC INDEX; NECROSIS; NEOPLASM GRADING; PREDICTIVE VALUE OF TESTS; THORACIC NEOPLASMS; TIME FACTORS; TRANS-ACTIVATORS; YOUNG ADULT;

EID: 84919342049     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000346     Document Type: Article

References (20)

1. OConnell JX, Nielsen GP, Rosenberg AE. Epithelioid vascular tumors of bone: a review and proposal of a classification scheme. Adv Anat Pathol. 2001;8:74-82.
2. Wenger DE, Wold LE. Malignant vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol. 2000;29:619-631.
3. Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50: 970-981.
4. Deyrup AT, Tighiouart M, Montag AG, et al. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol. 2008;32:924-927.
5. Errani C, Zhang L, Sung YS, et al. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer. 2011;50:644-653.
6. Tanas MR, Sboner A, Oliveira AM, et al. Identification of a diseasedefining gene fusion in epithelioid hemangioendothelioma. Sci Transl Med. 2011;3:98ra82.
7. Antonescu CR, Le Loarer F, Mosquera JM, et al. Novel YAP1- TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer. 2013;52:775-784.
8. Antonescu CR, Zhang L, Chang NE, et al. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010;49:1114-1124.
9. Luburich P, Ayuso MC, Picado C, et al. CT of pulmonary epithelioid hemangioendothelioma. J Comput Assist Tomogr. 1994;18:562-565.
10. Liu K, Xie P, Peng W, et al. The computed tomographic findings of pulmonary epithelioid hemangioendothelioma. Radiol Med. 2014; 119:705-713.
11. Mukundan G, Urban BA, Askin FB, et al. Pulmonary epithelioid hemangioendothelioma: atypical radiologic findings of a rare tumor with pathologic correlation. J Comput Assist Tomogr. 2000;24: 719-720.
12. Yousem SA, Hochholzer L. Unusual thoracic manifestations of epithelioid hemangioendothelioma. Arch Pathol Lab Med. 1987;111: 459-463.
13. Lin BT, Colby T, Gown AM, et al. Malignant vascular tumors of the serous membranes mimicking mesothelioma. A report of 14 cases. Am J Surg Pathol. 1996;20:1431-1439.
14. Dail DH, Liebow AA, Gmelich JT, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer. 1983;51:452-464.
15. Miettinen M, Fetsch JF. Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol. 2000;31:1062-1067.
16. Lau K, Massad M, Pollak C, et al. Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer. Chest. 2011;140:1312-1318.
17. Zhang PJ, Livolsi VA, Brooks JJ. Malignant epithelioid vascular tumors of the pleura: report of a series and literature review. Hum Pathol. 2000;31:29-34.
18. Suster S, Moran CA, Koss MN. Epithelioid hemangioendothelioma of the anterior mediastinum. Clinicopathologic, immunohistochemical, and ultrastructural analysis of 12 cases. Am J Surg Pathol. 1994;18:871-881.
19. Lahon B, Fabre D, De Montpreville V, et al. Epithelioid haemangioendothelioma of the superior vena cava. Interact Cardiovasc Thorac Surg. 2012;15:186-187.
20. Ferretti GR, Chiles C, Woodruff RD, et al. Epithelioid hemangioendothelioma of the superior vena cava: computed tomography demonstration and review of the literature. J Thorac Imaging. 1998;13:45-48.