Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

Science Translational Medicine

Volumn 3, Issue 98, 2011, Pages

  Tanas, Munir R ^a   Sboner, Andrea ^b   Oliveira, Andre M ^c   Erickson Johnson, Michele R ^c   Hespelt, Jessica ^a   Hanwright, Philip J ^a   Flanagan, John ^d   Luo, Yuling ^d   Fenwick, Kerry ^e   Natrajan, Rachael ^e   Mitsopoulos, Costas ^e   Zvelebil, Marketa ^e   Hoch, Benjamin L ^f   Weiss, Sharon W ^g   Debiec Rychter, Maria ^h   Sciot, Raf ^h   West, Rob B ⁱ   Lazar, Alexander J ^j   Ashworth, Alan ^e   Reis Filho, Jorge S ^e   Lord, Christopher J ^e   Gerstein, Mark B ^b,k   Rubin, Mark A ^l   Rubin, Brian P ^a   more..

^a TAUSSIG CANCER INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

^d Advanced Cell Diagnostics Inc   (United States)

^e INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^f UNIVERSITY OF WASHINGTON   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF LEUVEN   (Belgium)

ⁱ STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^k Yale University   (United States)

^l WEILL CORNELL MEDICAL COLLEGE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN BINDING TRANSCRIPTION ACTIVATOR 1; MESSENGER RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WW DOMAIN CONTAINING TRANSCRIPTION REGULATOR 1; CALCIUM BINDING PROTEIN; CAMTA1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TRANSACTIVATOR PROTEIN; WWTR1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CALMODULIN BINDING TRANSCRIPTION ACTIVATOR 1 GENE; CHIMERA; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUSION; GENE IDENTIFICATION; GENE REARRANGEMENT; GENE SEQUENCE; GENE SWITCHING; GENE TRANSLOCATION; GENETIC CODE; HEMANGIOENDOTHELIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR PATHOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RARE DISEASE; TRANSCRIPTION REGULATION; TUMOR GENE; TUMOR LOCALIZATION; WW DOMAIN CONTAINING TRANSCRIPTION REGULATOR 1 GENE; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; GENE EXPRESSION PROFILING; GENETICS; HUMAN GENOME; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; POLYMERASE CHAIN REACTION;

CALCIUM-BINDING PROTEINS; CHROMOSOME BREAKAGE; CYTOGENETIC ANALYSIS; GENE EXPRESSION PROFILING; GENE FUSION; GENOME, HUMAN; HEMANGIOENDOTHELIOMA, EPITHELIOID; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS;

EID: 80052349902     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002409     Document Type: Article

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28. Acknowledgments: We thank C. L. Corless (Oregon Health Sciences University) and M. van de Rijn (Stanford University) for assistance with construction of the vascular tumor tissue array. Primary human endothelial cells were gifts from the following individuals from the Cleveland Clinic: P. DiCorleto (HUVECs), D. Jacobsen (HAECs), S. Erzurum (PAECs), and R. Silverstein (DMVECs). Funding: This study was funded in part by Breakthrough Breast Cancer. Competing interests: The authors declare that they have no competing interests.