Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity

Journal of Biological Chemistry

Volumn 289, Issue 51, 2014, Pages 35265-35282

  Yamaguchi, Soichiro ^a,b   Tanimoto, Akira ^a   Otsuguro, Ken Ichi ^a   Hibino, Hiroshi ^b   Ito, Shigeo ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; CALMODULIN; ELECTROPHYSIOLOGY; MANGANESE; PHOSPHOLIPIDS; POSITIVE IONS;

ACIDIC AMINO ACIDS; MEMBRANE DEPOLARIZATION; MOLECULAR MECHANISM; MOLECULAR-BIOLOGICAL TECHNIQUES; MONOVALENT CATIONS; NEGATIVELY CHARGED; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; TRANSIENT RECEPTOR POTENTIALS;

CALCIUM;

ASPARTIC ACID; BARIUM ION; CADMIUM; CALCIUM ION; CARBON DIOXIDE; CHELATING AGENT; EDETIC ACID; EGTAZIC ACID; FLUORIDE ION; GLUTAMIC ACID; MAGNESIUM ION; MANGANESE; NICKEL; O PHENYLENEDIOXYDIACETIC ACID; STRONTIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; UNCLASSIFIED DRUG; ZINC ION; CALCIUM; COBALT; DIVALENT CATION; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM4 PROTEIN, RAT;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM METABOLISM; CALCIUM SENSITIVITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CURRENT AMPLITUDE; ELECTRICAL POTENTIAL PARAMETERS; ION CURRENT; MALE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP TECHNIQUE; POINT MUTATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; RAT; STEADY STATE; ANIMAL; BROWN NORWAY RAT; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; MEMBRANE POTENTIAL; METABOLISM; MUTATION; PHYSIOLOGY;

RATTUS;

ANIMALS; ASPARTIC ACID; BINDING SITES; CALCIUM; CATIONS, DIVALENT; COBALT; GLUTAMIC ACID; HEK293 CELLS; HUMANS; MALE; MEMBRANE POTENTIALS; MUTATION; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; RATS, INBRED BN; TRANSFECTION; TRPM CATION CHANNELS;

EID: 84919332655     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.606087     Document Type: Article

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