Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus;Avaliação da N-acetil-beta-D-glucosaminidase urinária como marcador de dano renal precoce em pacientes com diabetes melito tipo 2

Arquivos Brasileiros de Endocrinologia e Metabologia

Volumn 58, Issue 8, 2014, Pages 798-801

  Bouvet, Beatriz R ^a   Paparella, Cecilia V ^a   Arriaga, Sandra M M ^a   Monje, Adriana L ^a   Amarilla, Ana M ^a   Almará, Adriana M ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Diabetic nephropathy; Microalbuminuria; N acetyl beta D glucosaminidase; Tubular dysfunction; Type 2 diabetes mellitus

Indexed keywords

ACETYLGLUCOSAMINIDASE; BIOLOGICAL MARKER; CREATININE; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

AGED; ALBUMINURIA; ANALYSIS; BLOOD; COLORIMETRY; COMPLICATION; CROSS-SECTIONAL STUDY; DIABETIC NEPHROPATHIES; FEMALE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HUMAN; INJURIES; KIDNEY TUBULE; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY; URINE;

ACETYLGLUCOSAMINIDASE; AGED; ALBUMINURIA; BIOLOGICAL MARKERS; BLOOD GLUCOSE; COLORIMETRY; CREATININE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; GLOMERULAR FILTRATION RATE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; KIDNEY TUBULES; MALE; MIDDLE AGED;

EID: 84919329835     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/0004-2730000003010     Document Type: Article

References (17)

1. American Diabetes Association. Standards of Medical Care in Diabetes-2013. Diabetes Care. 2013;36(Suppl 1):S11-66.
2. Gilbert RE, Cooper ME. The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int. 1999;56:1627-37.
3. Comper WD, Hilliard LM, Nikolic-Paterson DJ, Russo LM. Disease-dependent mechanisms of albuminuria. Am J Physiol Renal Physiol. 2008;295:F1589-600.
4. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol. 2006;17:2974-84.
5. Hong CY, Chia KS. Markers of diabetic nephropathy. J Diabetes Complications. 1998;12:43-60.
6. Basturk T, Altuntas Y, Kurklu A, Avdin L, Eren N, Unsai A. Urinary N-acetyl-B glucosaminidase as an earlier marker of diabetic nephropathy and influence of low-dose perindopril/indapamide combination. Ren Fail. 2006;28:125-8.
7. Ikenaga H, Suzuki H, Ishii N, Itoh H, Saruta T. Enzymuria in non-insulin-dependent diabetic patients: signs of tubular cell dysfunction. Clin Sci (Lond). 1993;84:469-75.
8. Nauta FL, Boertien WE, Bakker SJ, van Goor H, van Oeveren W, de Jong PE, et al. Glomerular and tubular damage markers are elevated in patients with diabetes. Diabetes Care. 2011;34: 975-81.
9. Piwowar A, Knapik-Kordecka M, Fus I, Warwas M. Urinary activities of cathepsin B, N-acetyl-beta-D-glucosaminidase, and albuminuria in patients with type 2 diabetes mellitus. Med Sci Monit. 2006;12:CR210-14.
10. Farvid MS, Djalali M, Siassi F, Farvid S. Association of glomerular and tubular dysfunction with glycaemic control, lipid, lipoprotein, apolipoprotein and antioxidant status in type 2 diabetes mellitus. Singapore Med J. 2007;48:840-6.
11. Fujita H, Morii T, Koshimura J, Ishikawa M, Kato M, Miura T, et al. Possible relationship between adiponectin and renal tubular injury in diabetic nephropathy. Endocr J. 2006;53:745-52.
12. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005;67:2089-100.
13. Murussi M, Murussi N, Campagnolo N, Pinho Silveiro S. Detecção precoce da nefropatia diabética. Arq Bras Endrocrinol Metab. 2008;52:442-51.
14. Udomah FP, Ekpenyong Ekrikpo U, Effa E, Salako B, Arije A, Kadiri S. Association between Urinary N-Acetyl-Beta-D-Glucosaminidase and Microalbuminuria in Diabetic Black Africans. Int J Nephrol. 2012;2012:235-234.
15. Gibb D, Tomlinson P, Dalton N, Turner C, Shah V, Barratt T. Renal tubular proteinuria and microalbuminuria in diabetic patients. Arch Dis Child. 1989;64:129-34.
16. Vaidya V, Niewczas M, Ficociello L, Johnson A, Collings F, Warram J, et al. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1,and N-acetyl-b-D-glucosaminidase. Kidney Int. 2011;79:464-70.
17. Yamanouchi T, Kawasaki T, Yoshimura T, Inoue T, Koshibu E, Ogata N, et al. Relationship between serum 1,5-anhydroglucitol and urinary excretion of N-acetylglucosaminidase and albumin determined at onset of NIDDM with 3-year follow-up. Diabetes Care. 1998;21:619-24.