Markers of diabetic nephropathy

Journal of Diabetes and its Complications

Volumn 12, Issue 1, 1998, Pages 43-60

  Hong, Ching Ye ^a   Chia, Kee Seng ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA 1 MICROGLOBULIN; ANTIGEN; BETA 2 MICROGLOBULIN; BETA2 GLYCOPROTEIN 1; CHOLINESTERASE; FIBRONECTIN; GAMMA GLUTAMYLTRANSFERASE; MARKER; MICROSOMAL AMINOPEPTIDASE; N ACETYL BETA GLUCOSAMINIDASE; PROTEIN; RETINOL BINDING PROTEIN; TAMM HORSFALL GLYCOPROTEIN; TRANSFERRIN;

DIABETES MELLITUS; DIABETIC NEPHROPATHY; EARLY DIAGNOSIS; EXTRACELLULAR MATRIX; GLOMERULUS; HUMAN; KIDNEY INJURY; KIDNEY TUBULE; KIDNEY TUBULE EPITHELIUM; MICROALBUMINURIA; MOLECULAR WEIGHT; PRIORITY JOURNAL; REVIEW;

EID: 0031974608     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8727(97)00045-7     Document Type: Review

References (154)

1. Entmacher PS, Root HF, Marks HH Longevity in diabetic patients in recent years. Diabetes. 13:1964;373-377.
2. Morgensen CE, Christensen CK, Vittinghus E The stages of diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy Diabetes. 32(suppl 2):1983;64-78.
3. Deckert T, Anderson AR, Christiansen JS, Anderson JK Course of diabetic nephropathy. Factors related to development Acta Endocrinol. 97:1981;14-15.
4. Andersen AR, Christiansen JS, Andersen JK, Kreiner S, Deckert T Diabetic nephropathy in type I (insulin-dependent) diabetes. An epidemiological study Diabetologica. 25:1983;496-501.
5. Catalano C, Marshall SM Epidemiology of end-stage renal disease in patients with diabetes mellitus. From the dark ages to the middle ages Nephrol Dial Transplant. 7:1992;181-190.
6. Geiss LS, Herman WH, Teutsh SM Diabetes and renal mortality in the United States. Am J Public Health. 75:1985;1325-1326.
7. Fabre J, Balant LP, Dayer PG, Fox HM, Vernet AT The kidney in maturity-onset diabetes mellitus. Kidney Int. 21:1982;730-738.
8. Marshall SM, Alberti KGMM: Comparison of the prevalence and associated features of abnormal albumin excretion in insulin-dependent and non-insulin-dependent diabetes. Q J Med 70;61-71, 1989.
9. Damsgaard EM, Morgensen CE Microalbuminuria in elderly hyperglycaemic patients and controls. Diabetic Med. 3:1986;430-435.
10. Ballard DJ, Humphrey LL, Melton LJ, Frohnert PP, Chu PC, O'Fallon WM, Palumbo PJ Epidemiology of persistent proteinuria in type II diabetes mellitus. Diabetes. 37:1988;405-412.
11. Uusitupa M, Siitonen O, Penttilä I, Aro A, Pyörälä K Proteinuria in newly-diagnosed type II diabetic patients. Diabetes Care. 10:1987;101-104.
12. Parving HH, Oxenboll B, Svendsen PA, Christiansen JS, Anderson AR Early detection of patients at risk of developing diabetic nephropathy. Longitudinal study of urinary albumin excretion Acta Endocrinol. 100:1982;550-555.
13. Viberti GC, Jarrett RJ, Mahmud U, Hill RD Argyropoulos A, Keen H. Microalbuminuria as predictor of clinical nephropathy in insulin-dependent diabetes mellitus Lancet. 1:1982;1430-1432.
14. Mathieson ER, Oxenboll B, Johansen K, Svendsen PA, Deckert T Incipient nephropathy in type I (insulin-dependent) diabetes. Diabetologica. 26:1984;406-410.
15. Mogensen CE, Christensen CK Predicting diebetic nephropathy in insulin-dependent patients. N Engl J Med. 31:1984;89-93.
16. Viberti G Recent advances in understanding mechanisms and natural history of diabetic renal disease. Diabetes Care. 11:1988;3-9.
17. Jarett RJ, Viberti GC, Argyropoulos A, Hill RD, Mahmud U, Murrell TJ Microalbiuminuria predicts mortality in non-insulin-dependent diabetes. Diabetic Med. 1:1984;17-19.
18. Morgensen CE Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 310:1984;356-360.
19. Schmidt A, Vaeth M Microalbuminuria. A major risk factor in non-insulin-dependent diabetes. A 10-year follow-up study of 503 patients Diabetic Med. 5:1988;126-134.
20. Schmidt A The kidney in non-insulin-dependent diabetes. Studies on glomerular structure and function and the relationship between microalbuminuria and mortality. Acta Diabetologica. 29:1992;47-69.
21. Neil A, Hawkins M, Potok M, Thorogood M, Cohen D, Mann J A prospective population-based study of microalbuminuria as a predictor of mortality in NIDDM. Diabetes Care. 16:1993;996-1003.
22. Bending JJ, Viberti GC, Bilous RW, Keen H for the Kroc Collaborative Study Group. Eight-month correction of hyperglycaemia in insulin-dependent diabetes mellitus is associated with a significant and sustained reduction of urinary AERs in patients with microalbuminuria Diabetes. 34(suppl 3):1985;69-73.
23. Dahl-Jorgensen K, Hanssen KF, Kierulf P, Bjoro T, Sandvik L, Aegenaes O Reduction of urinary albumin excretion after 4 years of continuous subcutaneous insulin infusion in insulin-dependent diabetes mellitus. Acto Endocrinol. 117:1988;19-25.
24. Feldt-Rasmussen B, Mathiesen ER, Jensen T, Lauritzen T, Deckert T Effect of improved metabolic control on loss of kidney function in insulin-dependent diabetic patients. Diabetologica. 34:1991;164-170.
25. Reichard P, Berglund B, Britz A, Cars I, Nilsson BY, Rosenqvist U Intensified conventional insulin treatment retards the microvascular complications of insulin-dependent diabetes mellitus (IDDM). The Stockholm Diabetes Intervention Study after five years. Intern Med. 230:1991;101-108.
26. Kawazu S, Tomono S, Shimizu M, Kato N, Ohno T, Ishii C, Murata K, Watanabe T, Negishi K, Suzuki M, Takahashi M, Ishii J The relationship between early diabetic nephropathy and control of plasma glucose in non-insulin-dependent diabetes mellitus. J Diabet Complications. 8:1994;13-17.
27. Viberti G, Bending JJ Early diabetic nephropathy. Adv Nephrol. 17:1988;101-112.
28. Mimran A, Insua A, Ribstein J, Bringer J, Monnier L Comparative effect of captopril and nifedipine in normotensive patients with incipient diabetic nephropathy. Diabetes Care. 11:1988;850-853.
29. McCormick CP, Konen JC, Shihabi ZK Microtransferrinuria and microalbuminuria. I. In the diabetic human. Clin Physiol Biochem. 8:1990;53-58.
30. Konen JC, Summerson JH, Shihabi ZK Changes in diabetic urinary transferrin excretion after moderate exercise. Med Sci Sports Exers. 25:1993;1110-1114.
31. Bernard AM, Ouled A, Goemaere-Vanneste J, Antione JL, Lauwerys RR, Lambert A, Vandeleene B Microtransferrinuria is a more sensitive indicator of early glomerular damage in diabetes than microalbuminuria. Clin Chem. 34:1988;1920-1921.
32. Weber MH, Rothkegel S, Verwiebe R, Tewes C, Scheler F Urinary protein patterns in diabetic nephropathy. Contr Nephrol. 73:1989;30-44.
33. Aronoff SL, Schnider S, Smeltzer J, Mackay W, Tchou P, Rushforth N, Miller M, Bennett PH Urinary excretion and renal clearance of specific plasma proteins in diabetes of short and long duration. Diabetes. 30:1981;656-663.
34. Bernard A, Lauwerys R Continuous-flow system for the automation of latex immunoassay. Clin Chem. 28:1983;168-177.
35. Martin P, Handley T, Chapman C: Urinary transferrin - An early predictor of glomerular dysfunction [Abstract]. Ann Clin Biochem 1988; 25(suppl):158S.
36. Cheung CK, Cockram CS, Yeung VTF, Swaminathan R Urinary excretion of transferrin by non-insulin-depen- dent diabetics. A marker for early complications? Clin Chem. 35:1989;1672-1674.
37. Jerums G, Cooper ME, Seeman E, Murray RML, McNeil JJ Spectrum of proteinuria in type I and type II diabetes. Diabetes Care. 10:1987;419-427.
38. O'Donnel MJ, Martin P, Florkowski CM, Toop MJ, Chapman C, Holder R, Barnett AH Urinary transferrin excretion in type I (insulin dependent) diabetes mellitus. Diabetic Med. 8:1991;657-661.
39. Martin P, Walton C, Bodansky HJ, Sticklane MH Increased urinary excretion of transferrin in children with type I diabetes mellitus. Diabetic Med. 7:1990;35-40.
40. Kordonouri O, Jorres A, Muller C, Enders I, Gani GM, Weber B Quantitative assessment of urinary protein and enzyme excretion - A diagnostic programme for the detection of renal involvement in type I diabetes mellitus. Scand J Clin Lab Invest. 52:1992;781-790.
41. Martin P, Tindall H, Harvey JN, Handley TM, Chapman C, Davies JA Glomerular and tubular proteinuria in type I (insulin-dependent) diabetic patients with and without retinopathy. Ann Clin Biochem. 29:1992;256-270.
42. O'Donnel MJ, Martin P, Cavan D, Parkes A, Chapman J, Chapman C, Barnett AH Increased transferrin excretion in exercising normoalbuminuric insulin-dependent diabetic patients. Ann Clin Biochem. 28:1991;456-460.
43. O'Donnel MJ, Watson J, Martin P, Chapman C, Barnett AH Transferrinuria in type 2 diabetes. The effect of glycaemic control Ann Clin Biochem. 28:1991;174-178.
44. Yamazaki M, Tani N, Igarashi K, Nakamura H, Nomotsu T, Ito S, Shibata A Changes in the glomerular pore size selectivity in patients with type II diabetes mellitus. J Diabet Complications. 5:1991;138-139.
45. Konen J, Shihabi Z, Newman J The association of non-insulin-dependent diabetes mellitus and hypertension with urinary excretion of albumin and transferrin. Am J Kidney Dis. 22:1993;791-797.
46. Ishibashi F Glomerular clearance and tubular reabsorption of transferrin in microtransferrinuric patients with non-insulin-dependent diabetes. Diabetes Res Clin Pract. 25:1994;169-175.
47. Mosesson MV, Armani DL The structure and biologic activities of plasma fibronectin. Blood. 56:1980;145-158.
48. Jaffe EA, Mosher DF Synthesis of fibronectin by cultured endothelial cells. J Exp Med. 147:1978;1779-1791.
49. Owens MR, Cimino CD Synthesis of fibronectin by the isolated perfused rat liver. Blood. 59:1982;1305-1313.
50. Ginsberg MH, Painter RG, Berdwell C The detection, immunofluorescent localisation and thrombin-induce release of human platelet-associated fibronectin antigen. J Supramol Struct. 11:1974;167-174.
51. Wautier JL, Paton RC, Wautier MP, Pintigny D, Abadie E, Passa P, Caen JP Increased adhesion of erythrocytes to endothelial cells in diabetes mellitus and its relation to ascular complications. N Engl J med. 305:1981;237-242.
52. Solerte SB, Piovella F, Adamo S, Almasio P, Viola C, Ricetti MM, Ferrari E Plasma fibronectin and blood rheology in diabetic microangiopathy. Clin Hemorheol. 3:1983;315-320.
53. Schmid-Schonbein H, Volger E Red cell aggregation and red-cell deformity in diabetes. Diabetes. 25:1976;897-902.
54. Labat RJ, Chevalier X Fibronectin, ageing and related pathologies. C R Seances Soc Biol Fil. 185:1991;121-126.
55. Labat RJ, Kern P, Robert L Modifications of the biosynthesis of type I and type III collagens and fibronectin during diabetes and atherosclerosis. Z Gerontol. 24:1991;66-69.
56. Fraidakis M, Mantzavinos T, Dalamanga A, Gargaropoulos A, Zourlas PA Plasma and amniotic fluid concentration fibronectin during normal and diabetic pregnancy. Clin Exp Obstet Gynecol. 19:1992;98-102.
57. Davies TME Plasma fibronectin concentrations in diabetes and the effect of short term, improved glucose control [Abstract]. Diabetologica. 21:1981;262.
58. Bartolomei G, Seghieri G, De Giorgio LA, Gironi A, Chisci C, Niccolai M, Mammini P Plasma fibronectin in diabetes. Belfiore F, Galton DJ, Reaven GM Diabetes Mellitus. Etiopathogenesis and Metabolic Aspects:1984;269 S. Karger, Basel.
59. De Giorgia LA, Seghieri G, Gironi A, Mammini P, Bartoli U, Bartolomei G Raised plasma fibronectin concentration is related to the presence of diabetic retinopathy. Acta Diabetol. 21:1984;251-256.
60. De Giorgio LA, Bartolomei G, Gironi A, Caselli P, Seghieri G Increased plasm fibronectin concentration in diabetic patients with microalbuminuria. Diabetes Care. 11:1988;527-530.
61. Solerte SB, Piovella F, Viola C, Camevale C, Schianca GP, Gamba G, Fioravanti M, Ferrari E Plasma fibronectin, von Willibrand factor antigen and blood rheology. Association with diabetic microvascular disease Acta Diabetol. 22:1985;239-246.
62. Lee Ik, Park KY, Oh HK, Park RW, Jo JS Plasma type IV collagen and fibronectin concentrations in diabetic patients with microangiopathy. J Korean Med Sci. 9:1994;341-346.
63. Ozata M, Kurt I, Azal O, Bolu E, Corakci A, Beyhan Z, Karaca L, Gundogan MA Can we use plasma fibronectin levels as a marker for early diabetic nephropathy. Endocrinol J. 42:1995;301-305.
64. Isogai S, Tada H, Kuboki Ket al. Clinical significance of urinary fibronectin degradation products excretion in the development of diabetic nephropathy. Diabetes Res Clin Pract. Suppl(1-3):1987;S19.
65. Kuboki J, Tada H, Shin K, Oshima Y, Isogai S Relationship between urinary excretion of fibronectin degradation products and proteinuria in diabetic patients and their suppression after continuous subcutaneous heparin infusion. Diabetes Res Clin Pract. 21:1993;61-66.
66. Takahashi M Increased urinary fibronectin excretion in type II diabetic patients with microalbuminuria. Nippon Jinzo Gakkai Shi. 37:1995;336-342.
67. Beck K, Hunter I, Engel J Structure and function of laminin; anatomy of a multidomain glycoprotein. FASEB J. 4:1990;148-160.
68. Kleinman HK, Weeks BS, Schnaper HW, Kibbey MC, Yamamura K, Grant DS The laminins. A family of basement membrane glycoproteins important in cell differentiation and tumour metastases Vitam Horm. 47:1993;161-186.
69. Brocks DG, Strecker H, Nerbauer HP, Timpl R Radioimmunoassay of laminin in serum and its application to cancer patients. Clin Chem. 32:1986;787-791.
70. Miyake H, Nagashima K, Yagi H, Omigata K Urinary laminin P1 as an index of glycaemic control in children with insulin dependent diabetes mellitus. Diabetes Res. 23:1993;131-139.
71. Högemann B, Voss B, Altenwerth FJ, Schneider M, Rauterberg J Concentration of 7S collagen and laminin P1 in sera of patients with diabetes mellitus. Klin Wochenschr. 64:1986;382-385.
72. Tomono S, Kawazu S, Kato N, Ohno T, Utsugi T, Murata K Clinical implications of serum levels of basement membrane components in diabetic patients with and without albuminuria. J Diabetes Complications. 5:1991;193-194.
73. Hayashi Y, Makino H, Ota Z Serum and urinary concentrations of type IV collagen and laminin as marker of microangiopathy in diabetes. Diabetic Med. 9:1992;366-370.
74. Okazaki R, Matsuoka K, Atsumi Y, Maruyama K, Matsuki H, Okazaki T Serum concentrations of basement membrane proteins in NIDDM as a prognostic marker for nephropathy. Diabetes Res Clin Pract. 27:1995;39-49.
75. Banu N, Hara H, Okamura M, Egusa G, Yamakido M Urinary excretion of type IV collagen and laminin in the evaluation of nephropathy in NIDDM. Comparison with urinary albumin and markers of tubular dysfunction and/or damage Diabetes Res Clin Pract. 29:1995;57-67.
76. Nakajima C, Shimojo N, Naka K, Okuda K, Yamamoto M, Fujii S Clinical significance of urinary laminin P1 in diabetic patients. J Diabet Complications. 5:1991;197-198.
77. Ziyadeh FN Renal tubular membrane and collagen type IV in diabetes mellitus. Kidney Int. 43:1993;114-120.
78. Olgemoller B, Schleicher E Alterations of glomerular matrix proteins in the pathogenesis of diabetic nephropathy. Clin Invest Med. 71(suppl 5):1993;s13-19.
79. Matsumoto E, Matsumoto G, Bessho H, Kikuoka H, Nanjo K Serum concentrations of intact type IV collagen in diabetics. J Diabet Complications. 5:1991;189-190.
80. Watanabe T, Negishi K, Katayama S, Ishii J, Kawazu S Serum or urinary concentration of type IV collagen in diabetics. J Diabet Complications. 5:1991;191-192.
81. Hayashi Y, Makino H, Shikata K, Hartomo T, Yamasaki Y, Kumagai I, Ota Z Increased concentrations of the basement membrane component type IV collagen in sera and urine of diabetics. J Diabet Complications. 5:1991;195-196.
82. Olgemoller B, Schwaabe S, Gerbitz KD, Schleicher ED Elevated glucose decreases the content of a basement membrane associated heparan sulphate proteoglycan in proliferating cultured porcine mesangial cells. Diabetologica. 35:1992;183-186.
83. van den Born J, van Kraats AA, Bakker MA, Assmann KJ, van den Heuvel LP, Veerkamp JH, Berden JH Selective proteinuria in diabetic nephropathy in the rat basement membrane heparan sulphate. Diabetologica. 38:1995;161-172.
84. Makino H, Ikeda S, Haramoto T, Ota Z Heparan sulphate proteoglycans are lost in patients with diabetic nephropathy. Nephron. 61:1992;415-421.
85. Tamsma JT, van den Born J, Bruijn JA, Assmann KJ, Weening JJ, Berdem JH, Wieslander J, Schrama E, Hermans J, Veerkamp JH, Lemkes HHPJ, van der Woude FJ Expression of glomerular extracellular matrix components in human diabetic nephropathy. Decrease of heparan sulphate in the glomerular basement membrane Diabetologica. 37:1994;313-320.
86. Shield JP, Carradus M, Stone JE, Hunt LP, Baum JD, Pennock CA Urinary heparan sulphate proteoglycan excretion is abnormal in insulin dependent diabetes. Ann Clin Biochem. 32:1995;557-560.
87. Piscator M Markers of tubular dysfunction. Toxicol Lett. 46:1989;197-204.
88. 2-microglobulin, albumin and total protein J Clin Invest. 48:1969;1189-1198.
89. Butler EA, Flynn FV: The proteinuria of renal tubular disorders. Lancet ii:978-980, 1958.
90. Piscator M Proteinuria in chronic cadmium poisoning. 4. Gel-filtration and ion-exchange chromatography of urinary proteins from cadmium workers. Arch Environ Health. 12:1966;345-359.
91. Peterson PA, Berggård I Isolation and properties of a human retinol-transporting protein. Biochemistry. 10:1971;25-33.
92. Elkström B, Peterson PA, Berggård I A urinary and plasma protein of low molecular weight. Isolation and some properties Biochem Biophys Res Commun. 65:1975;1427-1433.
93. Lopes-Virella MF, Virella G, Rosebrock G, Sorgel J, Gonroles J, Calwell J Early diagnosis of renal manifestations in diabetics. Diabetologica. 16:1979;165-171.
94. Fletcher JA, Crockson RA, Mijovic C, Cooper EH, Bradwell AR, Barnett AH Low molecular weight proteinuria in insulin-dependent diabetes. Diabetes Res. 3:1986;203-206.
95. 2-microglobulin in apparently healthy subjects. Scand J Clin Lab Invest. 29:1972;69-74.
96. 2 microglobulin and retinol-binding protein in alkalinised patients with and without microalbuminuria Diabetes Res. 12:1989;31-36.
97. Mutti A, Ghiggeri GM, Bergamaschi E, Candiano G, Rasi A, Gusmano R, Franchini I, Borghetti A Urinary excretion of brush-border antigen and plasma proteins in early stages of diabetic nephropathy. Clin Chim Acta. 188:1990;93-100.
98. Sitjar de Togores AM, Muros de Fuentes M, Leon LC, Garcia NVM, Lopez ME, Rial RJM, Rodriguez RI, Trujillo AR Urinary excretion of N-acetyl-beta-D-glucosaminidase and microglobulin 2 in type I diabetes mellitus [Abstract]. An Esp Pediatr. 34:1991;225-229.
99. Asami T, Nakano T, Sakal K Study on the relation between renal tubular disorders and glomerular dysfunction in the early phase of insulin-dependent diabetes mellitus in children. Nippon Jinzo Gakkai Shi. 34:1992;57-63.
100. Ginervi F, Piccotti E, Alinovi R, DeToni T, Biagini C, Chiggeri GM, Gusmano R Reversible tubular proteinuria preceded microalbuminuria and correlates with the metabolic status in diabetic children. Pediatr Nephrol. 7:1993;23-26.
101. Stenouwer CD, Fischer HR, Hackeng WH, den Ottolander GJ, Donker AJ Diurnal variation in urinary protein excretion in diabetic nephropathy. Nephrol Dial Transplant. 6:1991;238-243.
102. Lervang HH, Jensen S, Brochner MJ, Ditzel J Does increased glomerular filtration rate of disturbed tubular dysfunciton early in the course of childhood type 1 diabetes predict the development of nephropathy? Diabetic Med. 9:1992;635-640.
103. Mocan Z, Erm C, Yildirim M, Telatar M, Deger O Urinary beta 2-microglobulin leels and urinary N-acetyl-beta-D-glucosaminidase enzyme activities in early diagnosis of non-insulin-dependent diabetes mellitus nephropathy. Diabetes Res. 26:1994;101-107.
104. Kanauchi M, Ishihara K, Nishioka H, Nishiura K, Dohi K Glomerular lesions in patients with non-insulin-dependent diabetes mellitus and microalbuminuria. Intern Med. 32:1993;753-757.
105. Niskanen L, Voutilainen R, Terasvirta M, Lehtinen J, Teppo AM, Groop L, Uusitupa M A prospective study of clinical and metabolic associates of proteinuria in patients with type 2 diabetes mellitus. Diabetic Med. 10:1993;543-549.
106. Neri S, Bruno CM Plasma beta 2-microglobulin in patients with non-insulin-dependent diabetes mellitus [Abstract]. Minerva Med. 86:1995;11-15.
107. Stiegler H, Standl E, Schulz K, Roth R, Lehmacher W Morbidity, mortality, and albuminuria in type 2 diabetic patients. A three-year prospective study of a random cohort in general practice Diabetic Med. 9:1992;646-653.
108. Shimizu H, Negishi M, Shimomura Y, Mori M Changes in urinary retinol-binding protein excretion and other indices of renal tubular damage in patients with non-insulin dependent diabetes. Diabetes Res Clin Pract. 18:1992;207-210.
109. Aoki Y, Yanagisawa Y, Oguchi H, Furuta S Contribution of hyperglycaemia and renal damage to urinary C-peptide clearance in non-insulin-dependent diabetic patietns. Diabetes Res Clin Pract. 14:1991;85-89.
110. Yu JY, Xiong NN, Guo HF Clinical observation on diabetic nephropathy treated with alcohol of abelmoschus manihot [Abstract]. Chung Kuo Ching Hsi I Chieh Ho Tsa Chih. 15:1995;263-265.
111. Lauwerys R, Bernard A Preclinical detection of nephrotoxicity. Description of the tests and appraisal of their health significance Toxicol Lett. 46:1989;13-29.
112. Lucertini S, Valcavi P, Mutti A, Franchini I Enzyme-linked immunosorbent assay of retinol-binding protein in serum and urine. Clin Chem. 30:1984;149-151.
113. Beetham R, Dawnay A, Landon J, Cattell R A radioimmunoassay for retinol-binding protein in serum and urine. Clin Chem. 31:1985;1364-1367.
114. Parviainen MT, Ylitalo P Immunoephelometric determination of retinol-binding protein in serum and urine. Clin Chem. 29:1983;853-856.
115. 2-microglobulin and retinol binding protein at different values of pH and temperature in normal and pathological urine. Clin Chim Acta. 195:1990;133-138.
116. 2-microglobulin determination in urine for the early detection of tubular proteinuria. Clin Chim Acta. 126:1982;1-7.
117. 2-microglobulin for the routine screening of renal tubular function Clin Chem. 27:1981;1781-1782.
118. Bernard AM, Vyskocil AA, Mahieu P, Lauwerys RR Assessment of urinary retinol-binding protein as an index of proximal tubular injury. Clin Chem. 33:1987;775-780.
119. Holm J, Hemmingsen L, Nielsen NV, Thomsen M Increased urinary ecretion of the retinol-binding protein in insulin-dependent diabetes mellitus in the absence of microalbuminuria. Clin Chim Acta. 170:1987;345-350.
120. Rowe DJF, Anthony F, Polak A, Shwa K, Ward CD, Watts GF Retinol binding protein as a small molecular weight marker of renal tubular function in diabetes mellitus. Ann Clin Biochem. 24:1987;477-482.
121. Catalano C, Winocour PH, Gillespie S, Gibb I, Alberti KG Effect of posture and acute glycaemic control on the excretion of retinol-binding protein in normoalbuminuric insulin-dependent diabetic patients. Clin Sci. 84:1993;461-467.
122. Pontuch P, Toserova E, Vozar J, Bulas J, Kratochvilova H 24-hour ambulatory blood pressure, daytime and night-time urinary albumin and retinol-binding protein excretion in type I diabetic patients. J Diabet Complications. 9:1995;234-236.
123. Kemp SF, Frindik JP Effect of metabolic control on serum protein concentrations in diabetes. Acta Paediatr Scand. 80:1991;938-943.
124. Holm J, Hemmingsen L, Nielsen V Low-molecular-mass proteinuria as a marker of proximal renal tubular dysfunction in normo- and microalbuminuric non-insulin-dependent diabetic subjects. Clin Chem. 39:1993;517-519.
125. Sumpio BE, Maack T Kinetics competition and selectivity of tubular absorption of proteins. Am J Physiol. 243:1982;F379-392.
126. Holm J, Nielsen NV, Hemmingsen L Retinopathy in type II diabetes mellitus associated with above-normal urinary excretion of RBP. Kidney Int Suppl. 47:1994;S105-108.
127. Kido T, Honda R, Yamada Y, Tsuritani I, Ishizaki M, Nogawa K α-1 microglobulin determination in urine for the early detection of tubular proteinuria caused by exposure to cadmium. Toxicol Lett. 24:1985;195-201.
128. Zimmerhackl LB, Pfeiderer S, Kinne R, Manz F, Schuler G, Brandis M Tamm-Horsfall-Protein excretion as a marker of ascending limb transport indicates early renal tubular damage in diabetes mellitus type I. J Diabet complications. 5:1991;112-114.
129. Pfleiderer S, Zimmerhackl LB, Kinne R, Manz F, Schuler G, Brandis M Renal proximal and distal tubular function is attenuated in diabetes mellitus type 1 as determined by the renal excretion of alpha 1-microglobulin and Tamm Horsfall protein. Clin Invest Med. 71:1993;972-977.
130. Wainal H, Katsukawa F, Takei T, Maruyama H, Kataoka K, Saruta T Influence of glycemic control and hypertension in urinary microprotein excretion in non-insulin-dependent diabetes mellitus. J Diabet Complications. 5:1991;160-161.
131. Bernard AM, Thielemans NO, Lauwerys RR Urinary protein 1 or Clara cell protein. A new sensitive marker of proximal tubular dysfunction Kidney Int Suppl. 47:1994;s34-37.
132. Ayates JO, Wright JW The use of urine protein 1 as an indicator of renal tubular function in type I (insulin-dependent) diabetes. Acta Med Hung. 50:1994;99-107.
133. Schenk EA, Schwarz RH, Lewis RA Tamm-Horsfall mucoprotein. Part 1. Localisation in the kidney Lab Invest. 25:1971;92-95.
134. Yu M, Zhu YQ Clinical significance of determination of urinary albumin, beta 2 microglobulin and Tamm-Horsfall protein in diabetics [Abstract]. Chung Hua Nei Ko Tsa Chih. 30:1991;354-356.
135. Lapsley M, Flynn FV, Sansom PA Beta 2-glycoprotein-1 (apolipoprotein H) excretion and renal tubular malfunction in diabetic patients without clinical proteinuria. J Clin Pathol. 46:1993;465-469.
136. Dubach UC, Le Hir M, Gandhi R Use of urinary enzymes as markers of nephrotoxicity. Toxicol Lett. 46:1988;193-196.
137. Price RG Measurement of N-acetyl-β-glucosaminidase and its isoenzymes in urine. Methods and clinical applications Eur J Clin Chem Clin Biochem. 30:1992;693-705.
138. Severini G, Alberti LM, Di Girolamo M N-acetyl-β-glucosaminidase (NAG) in serum and urine of patients with diabetes mellitus. Clin Chem. 34:1988;2430-2432.
139. Itoh Y, Numata Y, Morita A, Asano Y, Kawai T Varied value of urinary N-acetyl-beta-D-glucosaminidase isoenzyme B in males of reproductive age. Kidney Int Suppl. 47:1994;s38-42.
140. Matteucci E, Pellegrini L, Uncini-Manganelli C, Cecere M, Saviozzi M, Giampietro O Urinary cholinesterase activity is increased in insulin-dependent diabetics. Further evidence of diabetic tubular dysfunction Enzyme. 46:1992;315-318.
141. Jones AP, Lock S, Griffiths KD Urinary N-acetyl-beta-glucosaminidase activity in type I diabetes mellitus. Ann Clin Biochem. 32:1995;58-62.
142. Agardh CD, Agardh E, Isaksson A, Hultberg B Association between urinary N-aceytl-β-glucosaminidase and its isoenzyme patterns and microangiopathy in type 1 diabetes mellitus. Clin Chem. 37:1991;1696-1699.
143. Skrha J, Haas T, Sperl M, Stibor V, Stolba P A six-year follow-up of the relationship between N-acetyl-beta-glucosaminidase and albuminuria in relation to retinopathy. Diabetic Med. 8:1991;817-821.
144. Widstam-Attorps U, Berg U Urinary protein excretion and renal function in young people with diabetes mellitus. Nephrol Dial Transplant. 7:1992;487-492.
145. Maisant A, Sitzmann FC, Strohlein S N-acetyl-beta-glucosaminidase (beta-NAG) in urine. A parameter for early detection of diabetogenic nephropathy in childhood [Abstract]. 28:1993;77-80.
146. Skrha J, Hoding A, Kvansicka J, Stibor V, Sperl M, Stolba P, Hilgertova J Early changes of serum N-acetyl-beta-glucosaminidase, tissue plasminogen activator and erythrocyte superoxide dismutase in relation to retinopathy in type 1 diabetes mellitus. Clin Chim Acta. 229:1994;5-14.
147. Skrha J, Sperl M, Stolba P, Hilgertova J, Stibor V Albuminuria and N-acetyl-beta-glucosaminidase activity in a prospective study of type I diabetics [Abstract]. Vnitr Lek. 39:1993;699-705.
148. Ratzmann KP, Raskovic M, Schimke E The effect of blood pressure-reducing therapy with captopril on tubular marker excretion in type 1 diabetics with nephropathy. Dtsch Med Wochenschr. 119:1994;796-800.
149. Ikenaga H, Suzuki H, Ishii N, Itoh H, Saruta T Enzymuria in non-insulin-dependent patients. Signs of tubular cell dysfunction Clin Sci Colch. 84:1993;469-475.
150. Sanchez Hueso MC, Matea Cass J, Zamora Madaria E Influence of glycaemic blood glucose control and incipient diabetic nephropathy on the urinary excretion of N-acetyl-glucosaminidase (NAG) in diabetes mellitus. An Med Interna. 12:1995;216-220.
151. Nakamura S Clinical evaluation of urinary alanine aminopeptidase in the patients with diabetes mellitus - comparison among AAP, microalbumin and N-acetyl-beta-D-glucosaminidase [Abstract]. Hokkaido Igaku Zasshi. 66:1991;522-533.
152. Morita E, Kaizu K, Uriu K, Hashimoto O, Komine N, Eto S Clinical significance of urinary enzymes in diabetic nephropathy. J Diabet Complications. 5:1991;158-159.
153. Gosiewska A, Linalska T, Zarzycki W, Gorska M, Borejszo I Serum N-acetyl-beta-D-glucosaminidase (NAG) activity in patients with diabetes mellitus with reference to diabetic microangiopathy [Abstract]. Pol Tyg Lek. 47:1992;28-30.
154. Mutti A, Lucertini S, Valcavi PP, Neri TM, Fornari M, Alinovi R, Franchini L: Urinary excretion of brush-border antigens: Early indicators of toxic nephropathy. Lancet ii:914-917, 1985.