Expression of epithelial cell adhesion molecule associated with elevated ductular reactions in hepatocellar carcinoma

Clinics and Research in Hepatology and Gastroenterology

Volumn 38, Issue 6, 2014, Pages 699-705

  Xu, Minhui ^a,b   Qian, Guangyang ^b,c   Xie, Feng ^b   Shi, Changying ^b   Yan, Long ^b   Yu, Lihan ^b   Zheng, Tao ^b   Wei, Lixin ^b   Yang, Jiamei ^b  

^a SUZHOU MUNICIPAL HOSPITAL   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EPITHELIAL CELL ADHESION MOLECULE; CELL ADHESION MOLECULE; TUMOR ANTIGEN; TUMOR-ASSOCIATED ANTIGEN GA733;

ADULT; ARTICLE; CANCER PROGNOSIS; CELL DIFFERENTIATION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HEPATIC DUCT; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; STEM CELL; BIOSYNTHESIS; LIVER TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS;

ANTIGENS, NEOPLASM; CARCINOMA, HEPATOCELLULAR; CELL ADHESION MOLECULES; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS;

EID: 84919329489     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2014.04.015     Document Type: Article

References (25)

1. Llovet J.M. Updated treatment approach to hepatocellular carcinoma. J Gastroenterol 2005, 40:225-235.
2. Imamura H., Matsuyama Y., Tanaka E., Ohkubo T., Hasegawa K., Miyagawa S., et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 2003, 38:200-207.
3. Spizzo G., Fong D., Wurm M., Ensinger C., Obrist P., Hofer C., et al. EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis. J Clin Pathol 2011, 64:415-420.
4. Schmidt M., Hasenclever D., Schaeffer M., Boehm D., Cotarelo C., Steiner E., et al. Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer. Clin Cancer Res 2008, 14:5849-5855.
5. Varga M., Obrist P., Schneeberger S., Muhlmann G., Felgel-Farnholz C., Fong D., et al. Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival. Clin Cancer Res 2004, 10:3131-3136.
6. Spizzo G., Went P., Dirnhofer S., Obrist P., Moch H., Baeuerle P.A., et al. Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer. Gynecol Oncol 2006, 103:483-488.
7. Fong D., Steurer M., Obrist P., Barbieri V., Margreiter R., Amberger A., et al. Ep-CAM expression in pancreatic and ampullary carcinomas: frequency and prognostic relevance. J Clin Pathol 2008, 61:31-35.
8. Yamashita T., Forgues M., Wang W., Kim J.W., Ye Q., Jia H., et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res 2008, 68:1451-1461.
9. Murakata A., Tanaka S., Mogushi K., Yasen M., Noguchi N., Irie T., et al. Gene expression signature of the gross morphology in hepatocellular carcinoma. Ann Surg 2011, 253:94-100.
10. Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 2004, 39:1477-1487.
11. Roskams T. Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 2006, 25:3818-3822.
12. Lowes K.N., Brennan B.A., Yeoh G.C., Olynyk J.K. Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 1999, 154:537-541.
13. Theise N.D., Yao J.L., Harada K., Hytiroglou P., Portmann B., Thung S.N., et al. Hepatic 'stem cell' malignancies in adults: four cases. Histopathology 2003, 43:263-271.
14. Komuta M., Spee B., Vander Borght S., De Vos R., Verslype C., Aerts R., et al. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology 2008, 47:1544-1556.
15. Bruix J., Llovet J.M. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002, 35:519-524.
16. Hickman I.J., Clouston A.D., Macdonald G.A., Purdie D.M., Prins J.B., Ash S., et al. Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C. Gut 2002, 51:89-94.
17. Park Y.N., Kojiro M., Di Tommaso L., Dhillon A.P., Kondo F., Nakano M., et al. Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. In book ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer 2007, 109:915-923.
18. de Boer C.J., van Krieken J.H., Janssen-van Rhijn C.M., Litvinov S.V. Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver. J Pathol 1999, 188:201-206.
19. Zhang L., Theise N., Chua M., Reid L.M. The stem cell niche of human livers: symmetry between development and regeneration. Hepatology 2008, 48:1598-1607.
20. Yamashita T., Ji J., Budhu A., Forgues M., Yang W., Wang H.Y., et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 2009, 136. 1012-1024.e1014.
21. Sell S., Dunsford H.A. Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am J Pathol 1989, 134:1347-1363.
22. Sell S. Cellular origin of hepatocellular carcinomas. Semin Cell Dev Biol 2002, 13:419-424.
23. Tang Y., Kitisin K., Jogunoori W., Li C., Deng C.X., Mueller S.C., et al. Progenitor/stem cells give rise to liver cancer due to aberrant TGF- and IL-6 signaling. Proc Natl Acad Sci 2008, 105:2445-2450.
24. Libbrecht L., Desmet V., Van Damme B., Roskams T. The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol 2000, 33:76-84.
25. Clouston A.D., Powell E.E., Walsh M.J., Richardson M.M., Demetris A.J., Jonsson J.R. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 2005, 41:809-818.