Early aortic valve inflammation precedes calcification: A longitudinal FDG-PET/CT study

Atherosclerosis

Volumn 238, Issue 2, 2015, Pages 165-172

  Abdelbaky, Amr ^a   Corsini, Erin ^a   Figueroa, Amparo L ^a   Subramanian, Sharath ^a   Fontanez, Sara ^a   Emami, Hamed ^a   Hoffmann, Udo ^a   Narula, Jagat ^b   Tawakol, Ahmed ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Aortic valve calcification; Aortic valve inflammation; FED PET

Indexed keywords

CALCIUM; FLUORODEOXYGLUCOSE F 18; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; AORTA VALVE CALCIFICATION; AORTA VALVE DISEASE; AORTA VALVE INFLAMMATION; ARTICLE; CARDIOVASCULAR RISK; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DISEASE CLASSIFICATION; DISEASE COURSE; FEMALE; FOLLOW UP; HEALTH SURVEY; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; AORTA VALVE; AORTIC VALVE STENOSIS; CALCINOSIS; DIAGNOSTIC USE; INCIDENCE; INFLAMMATION; LONGITUDINAL STUDY; MULTIMODAL IMAGING; MULTIVARIATE ANALYSIS; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY; PREDICTIVE VALUE; RADIOGRAPHY; REPRODUCIBILITY; RISK; RISK FACTOR; SCINTISCANNING; TIME; UNITED STATES;

AGED; AORTIC VALVE; AORTIC VALVE STENOSIS; BOSTON; CALCINOSIS; DISEASE PROGRESSION; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; INCIDENCE; INFLAMMATION; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MULTIMODAL IMAGING; MULTIVARIATE ANALYSIS; ODDS RATIO; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84918843303     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.11.026     Document Type: Article

References (36)

1. Freeman R.V., Otto C.M. Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation 2005, 111:3316-3326.
2. Olsson M., Dalsgaard C.J., Haegerstrand A., Rosenqvist M., Ryden L., Nilsson J. Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J.Am. Coll. Cardiol. 1994, 23:1162-1170.
3. Otto C.M., Kuusisto J., Reichenbach D.D., Gown A.M., O'Brien K.D. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994, 90:844-853.
4. Rajamannan N.M., Subramaniam M., Rickard D., Stock S.R., Donovan J., Springett M., Orszulak T., Fullerton D.A., Tajik A.J., Bonow R.O., Spelsberg T. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003, 107:2181-2184.
5. Aikawa E., Nahrendorf M., Sosnovik D., Lok V.M., Jaffer F.A., Aikawa M., Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 2007, 115:377-386.
6. Rudd J.H., Narula J., Strauss H.W., Virmani R., Machac J., Klimas M., Tahara N., Fuster V., Warburton E.A., Fayad Z.A., Tawakol A.A. Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time?. J.Am. Coll. Cardiol. 2010, 55:2527-2535.
7. Hyafil F., Cornily J.C., Rudd J.H., Machac J., Feldman L.J., Fayad Z.A. Quantification of inflammation within rabbit atherosclerotic plaques using the macrophage-specific CT contrast agent N1177: a comparison with 18F-FDG PET/CT and histology. J.Nucl. Med. 2009, 50:959-965.
8. Zhang Z., Machac J., Helft G., Worthley S.G., Tang C., Zaman A.G., Rodriguez O.J., Buchsbaum M.S., Fuster V., Badimon J.J. Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: a histopathological correlation. BMC Nucl. Med. 2006, 6:3.
9. Tawakol A., Migrino R.Q., Hoffmann U., Abbara S., Houser S., Gewirtz H., Muller J.E., Brady T.J., Fischman A.J. Noninvasive invivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography. J.Nucl. Cardiol. 2005, 12:294-301.
10. Font M.A., Fernandez A., Carvajal A., Gamez C., Badimon L., Slevin M., Krupinski J. Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET. Front. Biosci. 2009, 14:3352-3360.
11. Marincheva-Savcheva G., Subramanian S., Qadir S., Figueroa A., Truong Q., Vijayakumar J., Brady T.J., Hoffmann U., Tawakol A. Imaging of the aortic valve using fluorodeoxyglucose positron emission tomography increased valvular fluorodeoxyglucose uptake in aortic stenosis. J.Am. Coll. Cardiol. 2011, 57:2507-2515.
12. Dweck M.R., Jones C., Joshi N.V., Fletcher A.M., Richardson H., White A., Marsden M., Pessotto R., Clark J.C., Wallace W.A., Salter D.M., McKillop G., van Beek E.J., Boon N.A., Rudd J.H., Newby D.E. Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis. Circulation 2012, 125:76-86.
13. Abdelbaky A., Corsini E., Figueroa A.L., Fontanez S., Subramanian S., Ferencik M., Brady T.J., Hoffmann U., Tawakol A. Focal arterial inflammation precedes subsequent calcification in the same location: a longitudinal FDG-PET/CT study. Circ. Cardiovasc Imaging 2013, 6:747-754.
14. Dweck M.R., Jenkins W.S., Vesey A.T., Pringle M.A., Chin C.W., Malley T.S., Cowie W.J., Tsampasian V., Richardson H., Fletcher A., Wallace W.A., Pessotto R., van Beek E.J., Boon N.A., Rudd J.H., Newby D.E. 18F-sodium fluoride uptake is a marker of active calcification and disease progression in patients with aortic stenosis. Circ. Cardiovasc Imaging 2014, 7:371-378.
15. Einstein A.J., Johnson L.L., Bokhari S., Son J., Thompson R.C., Bateman T.M., Hayes S.W., Berman D.S. Agreement of visual estimation of coronary artery calcium from low-dose CT attenuation correction scans in hybrid PET/CT and SPECT/CT with standard Agatston score. J.Am. Coll. Cardiol. 2010, 56:1914-1921.
16. Thanassoulis G., Massaro J.M., Cury R., Manders E., Benjamin E.J., Vasan R.S., Cupple L.A., Hoffmann U., O'Donnell C.J., Kathiresan S. Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium. J.Am. Coll. Cardiol. 2010, 55:2491-2498.
17. Callister T.Q., Cooil B., Raya S.P., Lippolis N.J., Russo D.J., Raggi P. Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method. Radiology 1998, 208:807-814.
18. Hokanson J.E., MacKenzie T., Kinney G., Snell-Bergeon J.K., Dabelea D., Ehrlich J., Eckel R.H., Rewers M. Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability. AJR Am. J. Roentgenol. 2004, 182:1327-1332.
19. Budoff M.J., Hokanson J.E., Nasir K., Shaw L.J., Kinney G.L., Chow D., Demoss D., Nuguri V., Nabavi V., Ratakonda R., Berman D.S., Raggi P. Progression of coronary artery calcium predicts all-cause mortality. JACC Cardiovasc Imaging 2010, 3:1229-1236.
20. McEvoy J.W., Blaha M.J. Progression of coronary artery calcification: not down-and-out. Arch. Intern. Med. 2010, 170:735-736. author reply 736.
21. Dweck M.R., Khaw H.J., Sng G.K., Luo E.L., Baird A., Williams M.C., Makiello P., Mirsadraee S., Joshi N.V., van Beek E.J., Boon N.A., Rudd J.H., Newby D.E. Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation?. Eur. Heart J. 2013, 34:1567-1574.
22. Agmon Y., Khandheria B.K., Meissner I., Sicks J.R., O'Fallon W.M., Wiebers D.O., Whisnant J.P., Seward J.B., Tajik A.J. Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study. J.Am. Coll. Cardiol. 2001, 38:827-834.
23. Allison M.A., Cheung P., Criqui M.H., Langer R.D., Wright C.M. Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis. Circulation 2006, 113:861-866.
24. Pohle K., Maffert R., Ropers D., Moshage W., Stilianakis N., Daniel W.G., Achenbach S. Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factors. Circulation 2001, 104:1927-1932.
25. Stewart B.F., Siscovick D., Lind B.K., Gardin J.M., Gottdiener J.S., Smith V.E., Kitzman D.W., Otto C.M. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J.Am. Coll. Cardiol. 1997, 29:630-634.
26. Taylor H.A., Clark B.L., Garrison R.J., Andrew M.E., Han H., Fox E.R., Arnett D.K., Samdarshi T., Jones D.W. Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans. Am. J. Cardiol. 2005, 95:401-404.
27. Messika-Zeitoun D., Bielak L.F., Peyser P.A., Sheedy P.F., Turner S.T., Nkomo V.T., Breen J.F., Maalouf J., Scott C., Tajik A.J., Enriquez-Sarano M. Aortic valve calcification: determinants and progression in the population. Arterioscler. Thromb. Vasc. Biol. 2007, 27:642-648.
28. Owens D.S., Katz R., Takasu J., Kronmal R., Budoff M.J., O'Brien K.D. Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA). Am. J. Cardiol. 2010, 105:701-708.
29. Min J.K., Lin F.Y., Gidseg D.S., Weinsaft J.W., Berman D.S., Shaw L.J., Rozanski A., Callister T.Q. Determinants of coronary calcium conversion among patients with a normal coronary calcium scan: what is the "warranty period" for remaining normal?. J.Am. Coll. Cardiol. 2010, 55:1110-1117.
30. Yoon H.C., Emerick A.M., Hill J.A., Gjertson D.W., Goldin J.G. Calcium begets calcium: progression of coronary artery calcification in asymptomatic subjects. Radiology 2002, 224:236-241.
31. Meirelles G.S., Gonen M., Strauss H.W. 18F-FDG uptake and calcifications in the thoracic aorta on positron emission tomography/computed tomography examinations: frequency and stability on serial scans. J.Thorac. Imaging 2011, 26:54-62.
32. Rudd J.H., Myers K.S., Bansilal S., Machac J., Woodward M., Fuster V., Farkouh M.E., Fayad Z.A. Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study. Circ. Cardiovasc Imaging 2009, 2:107-115.
33. Chan K.L., Teo K., Dumesnil J.G., Ni A., Tam J. Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial. Circulation 2010, 121:306-314.
34. Cowell S.J., Newby D.E., Prescott R.J., Bloomfield P., Reid J., Northridge D.B., Boon N.A. Arandomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N.Engl. J. Med. 2005, 352:2389-2397.
35. Rossebo A.B., Pedersen T.R., Boman K., Brudi P., Chambers J.B., Egstrup K., Gerdts E., Gohlke-Barwolf C., Holme I., Kesaniemi Y.A., Malbecq W., Nienaber C.A., Ray S., Skjaerpe T., Wachtell K., Willenheimer R. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N.Engl. J. Med. 2008, 359:1343-1356.
36. Budoff M.J., Nasir K., Kinney G.L., Hokanson J.E., Barr R.G., Steiner R., Nath H., Lopez-Garcia C., Black-Shinn J., Casaburi R. Coronary artery and thoracic calcium on noncontrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort. J.Cardiovasc Comput Tomogr. 2011, 5:113-118.