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Volumn 110, Issue , 2015, Pages 26-29

Medical genetics-based drug repurposing for Alzheimer's disease

Author keywords

Alzheimer's disease; Angiotensin converting enzyme inhibitors; Drug repurposing; Medical genetics

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; NOOTROPIC AGENT;

EID: 84918839466     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2014.11.003     Document Type: Review
Times cited : (8)

References (49)
  • 1
    • 84882730546 scopus 로고    scopus 로고
    • ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer's disease
    • AbdAlla S., Langer A., Fu X., Quitterer U. ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer's disease. Int. J. Mol. Sci. 2013, 14(8):16917-16942.
    • (2013) Int. J. Mol. Sci. , vol.14 , Issue.8 , pp. 16917-16942
    • AbdAlla, S.1    Langer, A.2    Fu, X.3    Quitterer, U.4
  • 2
    • 0020326438 scopus 로고
    • Angiotensin converting enzyme in Alzheimer's disease increased activity in caudate nucleus and cortical areas
    • Arregui A., Perry E.K., Rossor M., Tomlinson B.E. Angiotensin converting enzyme in Alzheimer's disease increased activity in caudate nucleus and cortical areas. J. Neurochem. 1982, 38(5):1490-1492.
    • (1982) J. Neurochem. , vol.38 , Issue.5 , pp. 1490-1492
    • Arregui, A.1    Perry, E.K.2    Rossor, M.3    Tomlinson, B.E.4
  • 3
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: identifying and developing new uses for existing drugs
    • Ashburn T.T., Thor K.B. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov. 2004, 3(8):673-683.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , Issue.8 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 4
    • 84887924089 scopus 로고    scopus 로고
    • Discovering new treatments for Alzheimer's disease by repurposing approved medications
    • Appleby B.S., Cummings J.L. Discovering new treatments for Alzheimer's disease by repurposing approved medications. Curr. Top. Med. Chem. 2013, 13:2306-2327.
    • (2013) Curr. Top. Med. Chem. , vol.13 , pp. 2306-2327
    • Appleby, B.S.1    Cummings, J.L.2
  • 5
    • 0025766144 scopus 로고
    • Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease
    • Barnes N.M., Cheng C.H., Costall B., Naylor R.J., Williams T.J., Wischik C.M. Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease. Eur. J. Pharmacol. 1991, 200(2-3):289-292.
    • (1991) Eur. J. Pharmacol. , vol.200 , Issue.2-3 , pp. 289-292
    • Barnes, N.M.1    Cheng, C.H.2    Costall, B.3    Naylor, R.J.4    Williams, T.J.5    Wischik, C.M.6
  • 6
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    • Bertram L., McQueen M.B., Mullin K., Blacker D., Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 2007, 39(1):17-23.
    • (2007) Nat. Genet. , vol.39 , Issue.1 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 9
    • 38949123654 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias
    • Casado A., López-Fernández M.E., Casado M.C., de La Torre R. Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochem. Res. 2008, 33(3):450-458.
    • (2008) Neurochem. Res. , vol.33 , Issue.3 , pp. 450-458
    • Casado, A.1    López-Fernández, M.E.2    Casado, M.C.3    de La Torre, R.4
  • 10
    • 0037409218 scopus 로고    scopus 로고
    • The angiotensin converting enzyme (ACE)
    • Coates D. The angiotensin converting enzyme (ACE). Int. J. Biochem. Cell Biol. 2003, 35(6):769-773.
    • (2003) Int. J. Biochem. Cell Biol. , vol.35 , Issue.6 , pp. 769-773
    • Coates, D.1
  • 12
    • 84880243950 scopus 로고    scopus 로고
    • Is a potential Alzheimer's therapy already in use for other conditions? Can medications for hypertension, diabetes and acne help with the symptoms?
    • Corbett A., Ballard C. Is a potential Alzheimer's therapy already in use for other conditions? Can medications for hypertension, diabetes and acne help with the symptoms?. Expert Opin. Investig. Drugs 2013, 22:941-943.
    • (2013) Expert Opin. Investig. Drugs , vol.22 , pp. 941-943
    • Corbett, A.1    Ballard, C.2
  • 13
    • 84894211326 scopus 로고    scopus 로고
    • Repackaging FDA-approved drugs for degenerative diseases: promises and challenges
    • Cummings J.L., Zhong K. Repackaging FDA-approved drugs for degenerative diseases: promises and challenges. Expert Rev. Clin. Pharmacol. 2014, 7:161-165.
    • (2014) Expert Rev. Clin. Pharmacol. , vol.7 , pp. 161-165
    • Cummings, J.L.1    Zhong, K.2
  • 14
    • 24644435956 scopus 로고    scopus 로고
    • Angiotensin-II behaves as an endogenous pro-inflammatory molecule
    • Das U.N. Angiotensin-II behaves as an endogenous pro-inflammatory molecule. J. Assoc. Physicians India 2005, 53:472-476.
    • (2005) J. Assoc. Physicians India , vol.53 , pp. 472-476
    • Das, U.N.1
  • 15
    • 80052647359 scopus 로고    scopus 로고
    • Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease
    • Dong Y.F., Kataoka K., Kataoka K., Tokutomi Y., Nako H., Nakamura T., Toyama K., Sueta D., Koibuchi N., Yamamoto E., Ogawa H., et al. Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 2011, 25(9):2911-2920.
    • (2011) FASEB J. , vol.25 , Issue.9 , pp. 2911-2920
    • Dong, Y.F.1    Kataoka, K.2    Kataoka, K.3    Tokutomi, Y.4    Nako, H.5    Nakamura, T.6    Toyama, K.7    Sueta, D.8    Koibuchi, N.9    Yamamoto, E.10    Ogawa, H.11
  • 17
    • 84870538997 scopus 로고    scopus 로고
    • Sildenafil provides sustained neuroprotection in the absence of learning recovery following the 4-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion in middle-aged rats
    • Dias Fiuza Ferreira E., Valerio Romanini C., Cypriano P.E., Weffort de Oliveira R.M., Milani H. Sildenafil provides sustained neuroprotection in the absence of learning recovery following the 4-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion in middle-aged rats. Brain Res. Bull. 2013, 90:58-65.
    • (2013) Brain Res. Bull. , vol.90 , pp. 58-65
    • Dias Fiuza Ferreira, E.1    Valerio Romanini, C.2    Cypriano, P.E.3    Weffort de Oliveira, R.M.4    Milani, H.5
  • 19
    • 0037162725 scopus 로고    scopus 로고
    • New therapies. New Alzheimer's treatments that may ease the mind
    • Helmuth L. New therapies. New Alzheimer's treatments that may ease the mind. Science 2002, 297(5585):1260-1262.
    • (2002) Science , vol.297 , Issue.5585 , pp. 1260-1262
    • Helmuth, L.1
  • 20
    • 33947245344 scopus 로고    scopus 로고
    • Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease
    • Hemming M.L., Selkoe D.J., Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiol. Dis. 2007, 26(1):273-281.
    • (2007) Neurobiol. Dis. , vol.26 , Issue.1 , pp. 273-281
    • Hemming, M.L.1    Selkoe, D.J.2    Farris, W.3
  • 21
    • 27844534846 scopus 로고    scopus 로고
    • Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor
    • Hemming M.L., Selkoe D.J. Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. J. Biol. Chem. 2005, 280(45):37644-37650.
    • (2005) J. Biol. Chem. , vol.280 , Issue.45 , pp. 37644-37650
    • Hemming, M.L.1    Selkoe, D.J.2
  • 22
    • 84901357361 scopus 로고    scopus 로고
    • Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines
    • Jin G., Wong S.T. Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines. Drug Discov. Today 2014, 19(5):637-644.
    • (2014) Drug Discov. Today , vol.19 , Issue.5 , pp. 637-644
    • Jin, G.1    Wong, S.T.2
  • 24
    • 33847791727 scopus 로고    scopus 로고
    • Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?
    • Kehoe P.G., Wilcock G.K. Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?. Lancet Neurol. 2007, 6:373-378.
    • (2007) Lancet Neurol. , vol.6 , pp. 373-378
    • Kehoe, P.G.1    Wilcock, G.K.2
  • 25
    • 46749115113 scopus 로고    scopus 로고
    • PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease
    • Landreth G., Jiang Q., Mandrekar S., Heneka M. PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics 2008, 5:481-489.
    • (2008) Neurotherapeutics , vol.5 , pp. 481-489
    • Landreth, G.1    Jiang, Q.2    Mandrekar, S.3    Heneka, M.4
  • 27
    • 74949127613 scopus 로고    scopus 로고
    • Antihypertensive agents and prevention of dementia
    • Maxwell C.J., Hogan D.B. Antihypertensive agents and prevention of dementia. BMJ 2010, 340:b5409.
    • (2010) BMJ , vol.340 , pp. b5409
    • Maxwell, C.J.1    Hogan, D.B.2
  • 32
    • 81855204959 scopus 로고    scopus 로고
    • Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA
    • Radak Z., Zhao Z., Goto S., Koltai E. Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA. Mol. Aspects Med. 2011, 32:305-315.
    • (2011) Mol. Aspects Med. , vol.32 , pp. 305-315
    • Radak, Z.1    Zhao, Z.2    Goto, S.3    Koltai, E.4
  • 33
    • 0034974108 scopus 로고    scopus 로고
    • Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia
    • Savaskan E., Hock C., Olivieri G., Bruttel S., Rosenberg C., Hulette C., Muller-Spahn F. Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia. Neurobiol. Aging 2001, 22(4):541-546.
    • (2001) Neurobiol. Aging , vol.22 , Issue.4 , pp. 541-546
    • Savaskan, E.1    Hock, C.2    Olivieri, G.3    Bruttel, S.4    Rosenberg, C.5    Hulette, C.6    Muller-Spahn, F.7
  • 34
    • 71749121407 scopus 로고    scopus 로고
    • Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review
    • Shah K., Qureshi S.U., Johnson M., Parikh N., Schulz P.E., Kunik M.E. Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review. Am. J. Geriatr. Pharmacother. 2009, 7(5):250-261.
    • (2009) Am. J. Geriatr. Pharmacother. , vol.7 , Issue.5 , pp. 250-261
    • Shah, K.1    Qureshi, S.U.2    Johnson, M.3    Parikh, N.4    Schulz, P.E.5    Kunik, M.E.6
  • 35
    • 84878068664 scopus 로고    scopus 로고
    • Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible involvement of PPAR-(agonistic property
    • Singh B., Sharma B., Jaggi A.S., Singh N. Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible involvement of PPAR-(agonistic property. J. Renin Angiotensin Aldosterone Syst. 2013, 14(2):124-136.
    • (2013) J. Renin Angiotensin Aldosterone Syst. , vol.14 , Issue.2 , pp. 124-136
    • Singh, B.1    Sharma, B.2    Jaggi, A.S.3    Singh, N.4
  • 36
    • 67650481228 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study?
    • Sink K.M., Leng X., Williamson J., Kritchevsky S.B., Yaffe K., Kuller L., Yasar S., Atkinson H., Robbins M., Psaty B., et al. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study?. Arch. Intern. Med. 2009, 169(13):1195-1202.
    • (2009) Arch. Intern. Med. , vol.169 , Issue.13 , pp. 1195-1202
    • Sink, K.M.1    Leng, X.2    Williamson, J.3    Kritchevsky, S.B.4    Yaffe, K.5    Kuller, L.6    Yasar, S.7    Atkinson, H.8    Robbins, M.9    Psaty, B.10
  • 37
    • 84884286721 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors and Alzheimer's disease progression in older adults: results from the Reseau sur la Maladie d'Alzheimer Francais cohort
    • Soto M.E., van Kan G.A., Nourhashemi F., Gillette-Guyonnet S., Cesari M., Cantet C., Rolland Y., Vellas B. Angiotensin-converting enzyme inhibitors and Alzheimer's disease progression in older adults: results from the Reseau sur la Maladie d'Alzheimer Francais cohort. J. Am. Geriatr. Soc. 2013, 61:1482-1488.
    • (2013) J. Am. Geriatr. Soc. , vol.61 , pp. 1482-1488
    • Soto, M.E.1    van Kan, G.A.2    Nourhashemi, F.3    Gillette-Guyonnet, S.4    Cesari, M.5    Cantet, C.6    Rolland, Y.7    Vellas, B.8
  • 38
    • 84867575084 scopus 로고    scopus 로고
    • Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains
    • Tian M., Zhu D., Xie W., Shi J. Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett. 2012, 586(20):3737-3745.
    • (2012) FEBS Lett. , vol.586 , Issue.20 , pp. 3737-3745
    • Tian, M.1    Zhu, D.2    Xie, W.3    Shi, J.4
  • 40
    • 84890046462 scopus 로고    scopus 로고
    • Rational drug repositioning by medical genetics
    • Wang Z.Y., Zhang H.Y. Rational drug repositioning by medical genetics. Nat. Biotechnol. 2013, 31(12):1080-1082.
    • (2013) Nat. Biotechnol. , vol.31 , Issue.12 , pp. 1080-1082
    • Wang, Z.Y.1    Zhang, H.Y.2
  • 41
    • 84863010950 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of protein networks provides insight into human genetic disease
    • Wang X., Wei X., Thijssen B., Das J., Lipkin S.M., Yu H. Three-dimensional reconstruction of protein networks provides insight into human genetic disease. Nat. Biotechnol. 2012, 30(2):159-164.
    • (2012) Nat. Biotechnol. , vol.30 , Issue.2 , pp. 159-164
    • Wang, X.1    Wei, X.2    Thijssen, B.3    Das, J.4    Lipkin, S.M.5    Yu, H.6
  • 42
    • 84856633096 scopus 로고    scopus 로고
    • Can medical genetics and evolutionary biology inspire drug target identification?
    • Wang Z.Y., Fu L.Y., Zhang H.Y. Can medical genetics and evolutionary biology inspire drug target identification?. Trends Mol. Med. 2012, 18(2):69-71.
    • (2012) Trends Mol. Med. , vol.18 , Issue.2 , pp. 69-71
    • Wang, Z.Y.1    Fu, L.Y.2    Zhang, H.Y.3
  • 43
    • 84891634884 scopus 로고    scopus 로고
    • Medical genetic inspirations for anticancer drug repurposing
    • Wang Z.Y., Quan Y., Zhang H.Y. Medical genetic inspirations for anticancer drug repurposing. Trends Pharmacol. Sci. 2014, 35(1):1-3.
    • (2014) Trends Pharmacol. Sci. , vol.35 , Issue.1 , pp. 1-3
    • Wang, Z.Y.1    Quan, Y.2    Zhang, H.Y.3
  • 45
    • 77956178798 scopus 로고    scopus 로고
    • Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease
    • Yamada K., Uchida S., Takahashi S., Takayama M., Nagata Y., Suzuki N., Shirakura S., Kanda T. Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease. Brain Res. 2010, 1352:176-186.
    • (2010) Brain Res. , vol.1352 , pp. 176-186
    • Yamada, K.1    Uchida, S.2    Takahashi, S.3    Takayama, M.4    Nagata, Y.5    Suzuki, N.6    Shirakura, S.7    Kanda, T.8
  • 46
    • 84887595537 scopus 로고    scopus 로고
    • The effects of perindopril on coognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress
    • Yang W.N., Han H., Hu X.D., Feng G.F., Qian Y.H. The effects of perindopril on coognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress. Pharmacol. Biochem. Behav. 2013, 114-115:31-36.
    • (2013) Pharmacol. Biochem. Behav. , pp. 31-36
    • Yang, W.N.1    Han, H.2    Hu, X.D.3    Feng, G.F.4    Qian, Y.H.5
  • 47
    • 84903461722 scopus 로고    scopus 로고
    • RIFAMPICIN: an antibiotic with brain protective function
    • Yulug B., Hanoglu L., Kilic E., Schabitz W.R. RIFAMPICIN: an antibiotic with brain protective function. Brain Res. Bull. 2014, 107:37-42.
    • (2014) Brain Res. Bull. , vol.107 , pp. 37-42
    • Yulug, B.1    Hanoglu, L.2    Kilic, E.3    Schabitz, W.R.4
  • 48
    • 79551541587 scopus 로고    scopus 로고
    • Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats
    • Zhu D., Shi J., Zhang Y., Wang B., Liu W., Chen Z., Tong Q. Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats. PLoS ONE 2011, 6(1):e16037.
    • (2011) PLoS ONE , vol.6 , Issue.1 , pp. e16037
    • Zhu, D.1    Shi, J.2    Zhang, Y.3    Wang, B.4    Liu, W.5    Chen, Z.6    Tong, Q.7


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