메뉴 건너뛰기




Volumn 2, Issue 5, 2014, Pages 503-509

The Risks, Benefits, and Uncertainties of Stepping Down Asthma Medications

Author keywords

Anti asthmatic agents; Asthma; Cessation; Decrease; Discontinue; Step down; Wean; Withdraw

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; EOSINOPHIL CATIONIC PROTEIN; EOTAXIN; LEUKOTRIENE RECEPTOR STIMULATING AGENT; LONG ACTING BETA AGONIST; NITRIC OXIDE; UNCLASSIFIED DRUG; ANTIASTHMATIC AGENT;

EID: 84918832074     PISSN: 22132198     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaip.2014.03.004     Document Type: Article
Times cited : (16)

References (54)
  • 1
    • 84926193425 scopus 로고    scopus 로고
    • Global Strategy for Asthma Management and Prevention 2011 update
    • Available from: Accessed December 29
    • Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2011 update. Available from: . Accessed December 29, 2013. http://www.ginasthma.org/uploads/users/files/GINA_Report_2011.pdf.
    • (2013)
  • 2
    • 84926220327 scopus 로고    scopus 로고
    • National Asthma Education and Prevention Program
    • Available from: Accessed December 29
    • National Heart Lung and Blood Institute. National Asthma Education and Prevention Program. Available from: . Accessed December 29, 2013. http://www.nhlbi.nih.gov/about/naepp/.
    • (2013)
  • 4
    • 84890289336 scopus 로고    scopus 로고
    • Inhaled corticosteroids and the risk of pneumonia in people with asthma: a case-control study
    • McKeever T., Harrison T.W., Hubbard R., Shaw D. Inhaled corticosteroids and the risk of pneumonia in people with asthma: a case-control study. Chest 2013, 144:1788-1794.
    • (2013) Chest , vol.144 , pp. 1788-1794
    • McKeever, T.1    Harrison, T.W.2    Hubbard, R.3    Shaw, D.4
  • 5
    • 77950481806 scopus 로고    scopus 로고
    • The FDA and safe use of long-acting beta-agonists in the treatment of asthma
    • Chowdhury B.A., Dal Pan G. The FDA and safe use of long-acting beta-agonists in the treatment of asthma. NEngl J Med 2010, 362:1169-1171.
    • (2010) NEngl J Med , vol.362 , pp. 1169-1171
    • Chowdhury, B.A.1    Dal Pan, G.2
  • 6
    • 61849130565 scopus 로고    scopus 로고
    • Asthma
    • Fanta C.H. Asthma. NEngl J Med 2009, 360:1002-1014.
    • (2009) NEngl J Med , vol.360 , pp. 1002-1014
    • Fanta, C.H.1
  • 7
    • 84890353043 scopus 로고    scopus 로고
    • The optimal practice of evidence-based medicine: incorporating patient preferences in practice guidelines
    • Montori V.M., Brito J.P., Murad M.H. The optimal practice of evidence-based medicine: incorporating patient preferences in practice guidelines. JAMA 2013, 310:2503-2504.
    • (2013) JAMA , vol.310 , pp. 2503-2504
    • Montori, V.M.1    Brito, J.P.2    Murad, M.H.3
  • 9
    • 84885822183 scopus 로고    scopus 로고
    • Full disclosure: out-of-pocket costs as side effects
    • Ubel P.A., Abernethy A.P., Zafar S.Y. Full disclosure: out-of-pocket costs as side effects. NEngl J Med 2013, 369:1484-1486.
    • (2013) NEngl J Med , vol.369 , pp. 1484-1486
    • Ubel, P.A.1    Abernethy, A.P.2    Zafar, S.Y.3
  • 11
    • 15744362248 scopus 로고    scopus 로고
    • Switching asthma patients to a once-daily inhaled steroid improves compliance and reduces healthcare costs
    • Guest J.F., Davie A.M., Ruiz F.J., Greener M.J. Switching asthma patients to a once-daily inhaled steroid improves compliance and reduces healthcare costs. Prim Care Respir J 2005, 14:88-98.
    • (2005) Prim Care Respir J , vol.14 , pp. 88-98
    • Guest, J.F.1    Davie, A.M.2    Ruiz, F.J.3    Greener, M.J.4
  • 12
    • 48949114938 scopus 로고    scopus 로고
    • Maintaining asthma control in persistent asthma: comparison of three strategies in a 6-month double-blind randomized study
    • Godard P., Greillier P., Pigearias B., Nachbaur G., Desfougeres J.L., Attali V. Maintaining asthma control in persistent asthma: comparison of three strategies in a 6-month double-blind randomized study. Respir Med 2008, 102:1124-1131.
    • (2008) Respir Med , vol.102 , pp. 1124-1131
    • Godard, P.1    Greillier, P.2    Pigearias, B.3    Nachbaur, G.4    Desfougeres, J.L.5    Attali, V.6
  • 13
    • 54949154566 scopus 로고    scopus 로고
    • Deterioration in asthma control when subjects receiving fluticasone propionate/salmeterol 100/50 mcg Diskus are "stepped-down."
    • Koenig S.M., Ostrom N., Pearlman D., Waitkus-Edwards K., Yancey S., Prilaman B.A., et al. Deterioration in asthma control when subjects receiving fluticasone propionate/salmeterol 100/50 mcg Diskus are "stepped-down.". JAsthma 2008, 45:681-687.
    • (2008) JAsthma , vol.45 , pp. 681-687
    • Koenig, S.M.1    Ostrom, N.2    Pearlman, D.3    Waitkus-Edwards, K.4    Yancey, S.5    Prilaman, B.A.6
  • 14
    • 76149101621 scopus 로고    scopus 로고
    • Efficacy and safety of budesonide/formoterol pressured metered-dose inhaler: randomized controlled trial comparing once-and twice-daily dosing in patients with asthma
    • Berger W.E., Bleeker E.R., O'Dowd L., Miller C.J., Mezzanotte W. Efficacy and safety of budesonide/formoterol pressured metered-dose inhaler: randomized controlled trial comparing once-and twice-daily dosing in patients with asthma. Allergy Asthma Proc 2010, 31:49-59.
    • (2010) Allergy Asthma Proc , vol.31 , pp. 49-59
    • Berger, W.E.1    Bleeker, E.R.2    O'Dowd, L.3    Miller, C.J.4    Mezzanotte, W.5
  • 15
    • 77953928883 scopus 로고    scopus 로고
    • Down-titration from high-dose combination therapy in asthma: removal of long-acting beta(2)-agonist
    • Reddel H.K., Gibson P.G., Peters M.J., Wark P.A., Sand I.B., Hoyos C.M., et al. Down-titration from high-dose combination therapy in asthma: removal of long-acting beta(2)-agonist. Respir Med 2010, 104:1110-1120.
    • (2010) Respir Med , vol.104 , pp. 1110-1120
    • Reddel, H.K.1    Gibson, P.G.2    Peters, M.J.3    Wark, P.A.4    Sand, I.B.5    Hoyos, C.M.6
  • 17
    • 0025774963 scopus 로고
    • Reduction of budesonide after a year of increased use: a randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained
    • Juniper E.F., Kline P.A., Vanzieleghem M.A., Hargreave F.E. Reduction of budesonide after a year of increased use: a randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained. JAllergy Clin Immunol 1991, 87:483-489.
    • (1991) JAllergy Clin Immunol , vol.87 , pp. 483-489
    • Juniper, E.F.1    Kline, P.A.2    Vanzieleghem, M.A.3    Hargreave, F.E.4
  • 20
    • 0037901033 scopus 로고    scopus 로고
    • Stepping down inhaled corticosteroids in asthma: a randomized controlled trial
    • Hawkins G., McMahon A.D., Twaddle S., Wood S.F., Ford I., Thomson N.C. Stepping down inhaled corticosteroids in asthma: a randomized controlled trial. BMJ 2003, 326:1115.
    • (2003) BMJ , vol.326 , pp. 1115
    • Hawkins, G.1    McMahon, A.D.2    Twaddle, S.3    Wood, S.F.4    Ford, I.5    Thomson, N.C.6
  • 21
    • 79951812951 scopus 로고    scopus 로고
    • Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomized, double-blind, placebo-controlled trial
    • Martinez F.D., Chinchilli V.M., Morgan W.J., Boehmer S.J., Lemanske R.F., Mauger D.T., et al. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomized, double-blind, placebo-controlled trial. Lancet 2011, 377:650-657.
    • (2011) Lancet , vol.377 , pp. 650-657
    • Martinez, F.D.1    Chinchilli, V.M.2    Morgan, W.J.3    Boehmer, S.J.4    Lemanske, R.F.5    Mauger, D.T.6
  • 22
    • 34249021521 scopus 로고    scopus 로고
    • Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma
    • Papi A., Canonica G.W., Maestrelli P., Paggiaro P., Olivieri D., Pozzi E., et al. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. NEngl J Med 2007, 356:2040-2052.
    • (2007) NEngl J Med , vol.356 , pp. 2040-2052
    • Papi, A.1    Canonica, G.W.2    Maestrelli, P.3    Paggiaro, P.4    Olivieri, D.5    Pozzi, E.6
  • 23
    • 84895527766 scopus 로고    scopus 로고
    • The risk of asthma exacerbation after reducing inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials
    • Hagan J.B., Samant S.A., Volcheck G.V., Li J.T., Hagan C.R., Erwin P.J., et al. The risk of asthma exacerbation after reducing inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials. Allergy 2014, 69:510-516.
    • (2014) Allergy , vol.69 , pp. 510-516
    • Hagan, J.B.1    Samant, S.A.2    Volcheck, G.V.3    Li, J.T.4    Hagan, C.R.5    Erwin, P.J.6
  • 24
    • 84898764266 scopus 로고    scopus 로고
    • Effect of inhaled corticosteroid therapy step-down and dosing regimen on measures of asthma control
    • Price D., Chisholm A., Hillyer E.V., Burden A., von Ziegenweidt J., Svedsater H., et al. Effect of inhaled corticosteroid therapy step-down and dosing regimen on measures of asthma control. JAllergy Ther 2013, 4:1-8.
    • (2013) JAllergy Ther , vol.4 , pp. 1-8
    • Price, D.1    Chisholm, A.2    Hillyer, E.V.3    Burden, A.4    von Ziegenweidt, J.5    Svedsater, H.6
  • 25
    • 34249081246 scopus 로고    scopus 로고
    • Randomized comparison of strategies for reducing treatment in mild persistent asthma
    • American Lung Association Asthma Clinical Research Network
    • Randomized comparison of strategies for reducing treatment in mild persistent asthma. NEngl J Med 2007, 356:2027-2039. American Lung Association Asthma Clinical Research Network.
    • (2007) NEngl J Med , vol.356 , pp. 2027-2039
  • 26
    • 0028341327 scopus 로고
    • Comparison of patients' compliance with prescribed oral and inhaled asthma medications
    • Kelloway J.S., Wyatt R.A., Adlis S.A. Comparison of patients' compliance with prescribed oral and inhaled asthma medications. Arch Intern Med 1994, 154:1349-1352.
    • (1994) Arch Intern Med , vol.154 , pp. 1349-1352
    • Kelloway, J.S.1    Wyatt, R.A.2    Adlis, S.A.3
  • 27
    • 0035212498 scopus 로고    scopus 로고
    • Adherence to oral montelukast and inhaled fluticasone in children with persistent asthma
    • Sherman J., Patel P., Hutson A., Chesrown S., Hendeles L. Adherence to oral montelukast and inhaled fluticasone in children with persistent asthma. Pharmacotherapy 2001, 21:1464-1467.
    • (2001) Pharmacotherapy , vol.21 , pp. 1464-1467
    • Sherman, J.1    Patel, P.2    Hutson, A.3    Chesrown, S.4    Hendeles, L.5
  • 28
    • 68149123409 scopus 로고    scopus 로고
    • Impact of asthma controller medications on clinical, economic, and patient-reported outcomes
    • Tan H., Sarawate C., Singer J., Elward K., Cohen R.I., Smart B.A., et al. Impact of asthma controller medications on clinical, economic, and patient-reported outcomes. Mayo Clin Proc 2009, 84:675-684.
    • (2009) Mayo Clin Proc , vol.84 , pp. 675-684
    • Tan, H.1    Sarawate, C.2    Singer, J.3    Elward, K.4    Cohen, R.I.5    Smart, B.A.6
  • 29
    • 84875230783 scopus 로고    scopus 로고
    • The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: a systemic review and meta-analysis of randomized controlled trials
    • Rank M.A., Hagan J.B., Park M.A., Podjasek J.C., Samant S.A., Volcheck G.W., et al. The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: a systemic review and meta-analysis of randomized controlled trials. JAllergy Clin Immunol 2013, 131:724-729.
    • (2013) JAllergy Clin Immunol , vol.131 , pp. 724-729
    • Rank, M.A.1    Hagan, J.B.2    Park, M.A.3    Podjasek, J.C.4    Samant, S.A.5    Volcheck, G.W.6
  • 30
    • 0027366769 scopus 로고
    • Cessation of long-term treatment with inhaled corticosteroid (budesonide) in children with asthma results in deterioration
    • Waalkens H.J., Van Essen-Zandvliet E.E., Hughes M.D., Gerritsen J., Duiverman E.F., Knol K., et al. Cessation of long-term treatment with inhaled corticosteroid (budesonide) in children with asthma results in deterioration. Am Rev Respir Dis 1993, 148:1252-1257.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1252-1257
    • Waalkens, H.J.1    Van Essen-Zandvliet, E.E.2    Hughes, M.D.3    Gerritsen, J.4    Duiverman, E.F.5    Knol, K.6
  • 31
    • 0028023279 scopus 로고
    • Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma
    • Haahtela T., Jarvinen M., Kava T., Kiviranta K., Koskinen S., Lehtonen K., et al. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. NEngl J Med 1994, 331:700-705.
    • (1994) NEngl J Med , vol.331 , pp. 700-705
    • Haahtela, T.1    Jarvinen, M.2    Kava, T.3    Kiviranta, K.4    Koskinen, S.5    Lehtonen, K.6
  • 32
    • 0030882724 scopus 로고    scopus 로고
    • Fluticasone propionate powder administered through Diskhaler versus triamcinolone acetonide aerosol administered through metered-dose inhaler in patients with persistent asthma
    • Condemi J.J., Chervinsky P., Goldstein M.F., Ford L.B., Berger W.E., Ayars G.H., et al. Fluticasone propionate powder administered through Diskhaler versus triamcinolone acetonide aerosol administered through metered-dose inhaler in patients with persistent asthma. JAllergy Clin Immunol 1997, 100:467-474.
    • (1997) JAllergy Clin Immunol , vol.100 , pp. 467-474
    • Condemi, J.J.1    Chervinsky, P.2    Goldstein, M.F.3    Ford, L.B.4    Berger, W.E.5    Ayars, G.H.6
  • 33
    • 0035938606 scopus 로고    scopus 로고
    • 2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial
    • 2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA 2001, 285:2583-2593.
    • (2001) JAMA , vol.285 , pp. 2583-2593
    • Lazarus, S.C.1    Boushey, H.A.2    Fahy, J.V.3    Chinchilli, V.M.4    Lemanske, R.F.5    Sorkness, C.A.6
  • 34
    • 80052307183 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]
    • editors, Available from: Accessed December 18, 2013
    • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from: . Accessed December 18, 2013. http://www.cochrane-handbook.org.
    • (2011) The Cochrane Collaboration
    • Higgins, J.P.T.1    Green, S.2
  • 36
    • 33344478154 scopus 로고    scopus 로고
    • Predictors of symptom recurrence after low-dose inhaled corticosteroid cessation in mild persistent asthma
    • Tonelli M., Bacci E., Dente F.L., Bartoli M.L., Cianchetti S., Di Franco A., et al. Predictors of symptom recurrence after low-dose inhaled corticosteroid cessation in mild persistent asthma. Respir Med 2006, 100:622-629.
    • (2006) Respir Med , vol.100 , pp. 622-629
    • Tonelli, M.1    Bacci, E.2    Dente, F.L.3    Bartoli, M.L.4    Cianchetti, S.5    Di Franco, A.6
  • 39
    • 0036740081 scopus 로고    scopus 로고
    • Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: correlation with serum levels of eosinophil cationic protein
    • Baba K., Sakakibara A., Yagi T., Niwa S., Wakayama H., Takagi K. Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: correlation with serum levels of eosinophil cationic protein. Respirology 2002, 7:255-266.
    • (2002) Respirology , vol.7 , pp. 255-266
    • Baba, K.1    Sakakibara, A.2    Yagi, T.3    Niwa, S.4    Wakayama, H.5    Takagi, K.6
  • 40
    • 18644373492 scopus 로고    scopus 로고
    • Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children
    • Zacharasiewicz A., Wilson N., Lex C., Erin E.M., Li A.M., Hansei T., et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005, 171:1077-1082.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1077-1082
    • Zacharasiewicz, A.1    Wilson, N.2    Lex, C.3    Erin, E.M.4    Li, A.M.5    Hansei, T.6
  • 41
    • 72049100133 scopus 로고    scopus 로고
    • Loss of asthma control in inner city children with asthma after withdraw of asthma controller medication
    • Kwong K.Y.C., Morphew T., Huynh P., Scott L., Radjal N., Dale G. Loss of asthma control in inner city children with asthma after withdraw of asthma controller medication. JAsthma 2009, 46:1001-1005.
    • (2009) JAsthma , vol.46 , pp. 1001-1005
    • Kwong, K.Y.C.1    Morphew, T.2    Huynh, P.3    Scott, L.4    Radjal, N.5    Dale, G.6
  • 42
    • 84883645330 scopus 로고    scopus 로고
    • Step-down of budesonide/formoterol in early stages of asthma treatment leads to insufficient anti-inflammatory effect
    • Obase Y., Ikeda M., Kurose K., Abe M., Shimizu H., Ohue Y., et al. Step-down of budesonide/formoterol in early stages of asthma treatment leads to insufficient anti-inflammatory effect. JAsthma 2013, 50:718-721.
    • (2013) JAsthma , vol.50 , pp. 718-721
    • Obase, Y.1    Ikeda, M.2    Kurose, K.3    Abe, M.4    Shimizu, H.5    Ohue, Y.6
  • 43
    • 84926159182 scopus 로고    scopus 로고
    • Evaluation of step-down therapy from an inhaled steroid to montelukast in childhood asthma
    • [Epub ahead of print]
    • Ciolkowski J., Mazurek H., Stasiowska B. Evaluation of step-down therapy from an inhaled steroid to montelukast in childhood asthma. Allergol Immunopathol (Madr) 2013, May 16, [Epub ahead of print].
    • (2013) Allergol Immunopathol (Madr)
    • Ciolkowski, J.1    Mazurek, H.2    Stasiowska, B.3
  • 46
    • 34047217039 scopus 로고    scopus 로고
    • Asthma treatment in a population-based cohort: putting step-up and step-down treatment changes in context
    • Yawn B.P., Wollan P.C., Bertram S.L., Lowe D., Butterfield J.H., Bonde D., et al. Asthma treatment in a population-based cohort: putting step-up and step-down treatment changes in context. Mayo Clin Proc 2007, 82:414-421.
    • (2007) Mayo Clin Proc , vol.82 , pp. 414-421
    • Yawn, B.P.1    Wollan, P.C.2    Bertram, S.L.3    Lowe, D.4    Butterfield, J.H.5    Bonde, D.6
  • 47
    • 77953634969 scopus 로고    scopus 로고
    • Asthmatics able to step down from inhaled corticosteroid treatment without loss of asthma control have low serum eotaxin/CCL11
    • Hoffmann H.J., Nielsen L.P., Harving H., Heinig J.H., Dahl R. Asthmatics able to step down from inhaled corticosteroid treatment without loss of asthma control have low serum eotaxin/CCL11. Clin Respir J 2008, 2:149-157.
    • (2008) Clin Respir J , vol.2 , pp. 149-157
    • Hoffmann, H.J.1    Nielsen, L.P.2    Harving, H.3    Heinig, J.H.4    Dahl, R.5
  • 49
    • 82255165102 scopus 로고    scopus 로고
    • Risk factors for montelukast treatment failure in step-down therapy for controlled asthma
    • Drummond M.B., Peters S.P., Castro M., Holbrook J.T., Irvin C.G., Smith L.J., et al. Risk factors for montelukast treatment failure in step-down therapy for controlled asthma. JAsthma 2011, 48:1051-1057.
    • (2011) JAsthma , vol.48 , pp. 1051-1057
    • Drummond, M.B.1    Peters, S.P.2    Castro, M.3    Holbrook, J.T.4    Irvin, C.G.5    Smith, L.J.6
  • 50
    • 84866129261 scopus 로고    scopus 로고
    • Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial
    • Calhoun W.J., Ameredes B.T., King T.S., Icitovic N., Bleecker E.R., Castro M., et al. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA 2012, 308:987-997.
    • (2012) JAMA , vol.308 , pp. 987-997
    • Calhoun, W.J.1    Ameredes, B.T.2    King, T.S.3    Icitovic, N.4    Bleecker, E.R.5    Castro, M.6
  • 52
    • 79956341663 scopus 로고    scopus 로고
    • Internet-based tapering of oral corticosteroids in severe asthma: a pragmatic randomised controlled trial
    • Hashimoto S., Ten Brinke A., Roldaan A.C., van Zeen I.H., Moller G.M., Sont J.K., et al. Internet-based tapering of oral corticosteroids in severe asthma: a pragmatic randomised controlled trial. Thorax 2011, 66:514-520.
    • (2011) Thorax , vol.66 , pp. 514-520
    • Hashimoto, S.1    Ten Brinke, A.2    Roldaan, A.C.3    van Zeen, I.H.4    Moller, G.M.5    Sont, J.K.6
  • 53
    • 3843105981 scopus 로고    scopus 로고
    • High dose versus low dose inhaled corticosteroid as initial starting dose for asthma in adults and children
    • Powell H., Gibson P.G. High dose versus low dose inhaled corticosteroid as initial starting dose for asthma in adults and children. Cochrane Database Syst Rev 2009, 4.
    • (2009) Cochrane Database Syst Rev , vol.4
    • Powell, H.1    Gibson, P.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.