Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 12, 2014, Pages H1691-H1704

  Maizel, Julien ^a,c   Xavier, Sandhya ^c   Chen, Jun ^c   Lin, Chi Hua Sarah ^c   Vasko, Radovan ^a,b   Goligorsky, Michael S ^c  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Adriamycin cardiomyopathy; Angiogenesis; Echocardiography; Hypoxia; Transverse aortic constriction; VEGF

Indexed keywords

HYDROLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; SIRTUIN 1; SIRTUIN 1 INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SIRT1 PROTEIN, MOUSE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CAPILLARY DENSITY; CARDIOMYOPATHY; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DISEASE COURSE; DISEASE SEVERITY; ENDOTHELIUM CELL; ENZYME INACTIVATION; EX VIVO STUDY; HEART FUNCTION; HEART LEFT VENTRICULAR FIBROSIS; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSVERSE AORTIC CONSTRICTION; AGE; ANIMAL; CARDIOMEGALY; CORONARY BLOOD VESSEL; DIASTOLE; FIBROSIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART VENTRICLE; HEART VENTRICLE FUNCTION; METABOLISM; PATHOLOGY; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

AGE FACTORS; ANIMALS; CARDIOMEGALY; CORONARY VESSELS; DIASTOLE; ENDOTHELIUM, VASCULAR; FIBROSIS; HEART VENTRICLES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIRTUIN 1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR FUNCTION;

EID: 84918822609     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00281.2014     Document Type: Article

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