Intraepithelial macrophage infiltration is related to a high number of regulatory T cells and promotes a progressive course of HPV-induced vulvar neoplasia

International Journal of Cancer

Volumn 136, Issue 4, 2015, Pages E85-E94

  Van Esch, Edith M G ^a   Van Poelgeest, Mariette I E ^a   Trimbos, J Baptist M Z ^a   Fleuren, Gert Jan ^a   Jordanova, Ekaterina S ^a   Van Der Burg, Sjoerd H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD14; HPV; Macrophages; Usual VIN; Vulvar carcinoma

Indexed keywords

CD14 ANTIGEN; CD163 ANTIGEN; CD33 ANTIGEN;

ADULT; AGED; ARTICLE; BONE MARROW CELL; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER RISK; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MARKER; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE COUNT; M1 MACROPHAGE; M2 MACROPHAGE; MACROPHAGE; MACROPHAGE INFILTRATION; MACROPHAGE MIGRATION; MAJOR CLINICAL STUDY; RECURRENCE FREE SURVIVAL; REGULATORY T LYMPHOCYTE; RISK ASSESSMENT; TUMOR PROMOTION; VULVA TUMOR; VULVAR INTRAEPITHELIAL NEOPLASIA; WART VIRUS; CARCINOMA IN SITU; CASE CONTROL STUDY; DISEASE FREE SURVIVAL; IMMUNOLOGY; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; PAPILLOMAVIRUS INFECTION; PHYSIOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA IN SITU; CASE-CONTROL STUDIES; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MACROPHAGES; MIDDLE AGED; PAPILLOMAVIRUS INFECTIONS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; T-LYMPHOCYTES, REGULATORY; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; VULVAR NEOPLASMS; YOUNG ADULT;

EID: 84918797715     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29173     Document Type: Article

References (44)

1. De Vuijst H, Clifford GM, Nascimento MC, et al. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: A metaanalysis. Int J Cancer 2009;124:1626-36
2. Hillemanns P, Wang X, Staehle S, et al. Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy. Gynecol Oncol 2006;100:271-5
3. Van Seters M, Van Beurden M, de Craen AJ. Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol Oncol 2005;97:645-51
4. van de Nieuwenhof HP, van der Avoort IA, de Hullu JA. Review of squamous premalignant vulvar lesions. Crit Rev Oncol Hematol 2008;68: 131-56
5. Van Seters M, Van Beurden M, ten Kate FJ, et al. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N Engl J Med 2008;358: 1465-73
6. Kenter GG, Welters MJ, Valentijn AR, et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med 2009;361: 1838-47
7. Daayana S, Elkord E, Winters U, et al. Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia. Br J Cancer 2010;102:1129-36
8. Winters U, Daayana S, Lear JT, et al. Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia. Clin Cancer Res 2008;14:5292-9
9. Petry KU, Kochel H, Bode U, et al. Human papillomavirus is associated with the frequent detection of warty and basaloid high-grade neoplasia of the vulva and cervical neoplasia among immunocompromised women. Gynecol Oncol 1996;60:30-4
10. Jamieson DJ, Paramsothy P, Cu-Uvin S, et al. Vulvar, vaginal, and perianal intraepithelial neoplasia in women with or at risk for human immunodeficiency virus. Obstet Gynecol 2006;107: 1023-8
11. van Poelgeest MI, Van Seters M, Van Beurden M, et al. Detection of human papillomavirus (HPV) 16-specific CD41 T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment. Clin Cancer Res 2005;11:5273-80
12. van der Burg SH, Melief CJ. Therapeutic vaccination against human papilloma virus induced malignancies. Curr Opin Immunol 2011;23:252-7
13. Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 2012;12:253-68
14. Heusinkveld M, van der Burg SH. Identification and manipulation of tumor associated macrophages in human cancers. J Transl Med 2011;9: 216
15. Gottfried E, Kreutz M, Mackensen A. Tumorinduced modulation of dendritic cell function. Cytokine Growth Factor Rev 2008;19:65-77
16. Terlou A, Van Seters M, KleinJan A, et al. Imiquimod- induced clearance of HPV is associated with normalization of immune cell counts in usual type vulvar intraepithelial neoplasia. Int J Cancer 2010;127:2831-40
17. Van Seters M, Beckmann I, Heijmans-Antonissen C, et al. Disturbed patterns of immunocompetent cells in usual-type vulvar intraepithelial neoplasia. Cancer Res 2008;68:6617-22
18. Ambarus CA, Krausz S, van Eijk M, et al. Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods 2012;375:196-206
19. Martinez FO, Sica A, Mantovani A, et al. Macrophage activation and polarization. Front Biosci 2008;13:453-61
20. de Vos van Steenwijk PJ, Ramwadhdoebe TH, Goedemans R, et al. Tumor-infiltrating CD14- positive myeloid cells and CD8-positive T-cells prolong survival in patients with cervical carcinoma. Int J Cancer 2013
21. Abdel-Hady ES, Martin-Hirsch P, Duggan-Keen M, et al. Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy. Cancer Res 2001;61:192-6
22. Figel AM, Brech D, Prinz PU, et al. Human renal cell carcinoma induces a dendritic cell subset that uses T-cell crosstalk for tumor-permissive milieu alterations. Am J Pathol 2011;179:436-51
23. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005;5:953-64
24. Crocker PR, Varki A. Siglecs, sialic acids and innate immunity. Trends Immunol 2001;22:337-42
25. Buechler C, Ritter M, Orso E, et al. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by proand antiinflammatory stimuli. J Leukoc Biol 2000;67:97-103
26. Maniecki MB, Moller HJ, Moestrup SK, et al. CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes. Immunobiology 2006;211: 407-17
27. Lau SK, Chu PG, Weiss LM. CD163: A specific marker of macrophages in paraffin-embedded tissue samples. Am J Clin Pathol 2004;122:794-801
28. Van Gorp H, Delputte PL, Nauwynck HJ. Scavenger receptor CD163, a Jack-of-All-trades and potential target for cell-directed therapy. Mol Immunol 2010;47:1650-60
29. Sideri M, Jones RW, Wilkinson EJ, et al. Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med 2005;50:807-10
30. van Esch EM, van Poelgeest MI, Kouwenberg S, et al. Expression of co-inhibitory receptors on T cells in the microenvironment of usual VIN is related to differentiated proinflammatory effector T cells and an increased recurrence free survival. Submitted back to back to Int J Cancer 2014
31. van Esch EM, Tummers B, Baartmans V, et al. Alterations in classical and non-classical HLA expression in recurrent and progressive HPV induced vulvar intraepithelial neoplasia (uVIN) and implications for immunotherapy. Int J Cancer 2014;135:830-42
32. van den Brule AJ, Pol R, Fransen-Daalmeijer N, et al. GP51/61 PCR followed by reverse line blot analysis enables rapid and high-throughput identification of human papillomavirus genotypes. J Clin Microbiol 2002;40:779-87
33. Kleter B, van Doorn LJ, Schrauwen L, et al. Development and clinical evaluation of a highly sensitive PCR-reverse hybridization line probe assay for detection and identification of anogeni- tal human papillomavirus. J Clin Microbiol 1999; 37:2508-17
34. van Esch EM, Dam MC, Osse ME, et al. Clinical characteristics associated with development of recurrence and progression in usual-type vulvar intraepithelial neoplasia. Int J Gynecol Cancer 2013;23:1476-83
35. Yan J, Zhang Y, Zhang JP, et al. Tim-3 expression defines regulatory T cells in human tumors. PLoS One 2013;8:e58006
36. Ohri CM, Shikotra A, Green RH, et al. Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival. Eur Respir J 2009;33:118-26
37. Heys SD, Stewart KN, McKenzie EJ, et al. Characterisation of tumour-infiltrating macrophages: impact on response and survival in patients receiving primary chemotherapy for breast cancer. Breast Cancer Res Treat 2012;135:539-48
38. Kinouchi M, Miura K, Mizoi T, et al. Infiltration of CD14-positive macrophages at the invasive front indicates a favorable prognosis in colorectal cancer patients with lymph node metastasis. Hepatogastroenterology 2011;58:352-8
39. Kinouchi M, Miura K, Mizoi T, et al. Infiltration of CD40-positive tumor-Associated macrophages indicates a favorable prognosis in colorectal cancer patients. Hepatogastroenterology 2013;60:83-8
40. Ma J, Liu L, Che G, et al. The M1 form of tumor-Associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 2010;10:112
41. Del Pino M, Rodriguez-Carunchio L, Ordi J. Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. Histopathology 2013;62: 161-75
42. van de Nieuwenhof HP, van Kempen LC, de Hullu JA, et al. The etiologic role of HPV in vulvar squamous cell carcinoma fine tuned. Cancer Epidemiol Biomarkers Prev 2009;18:2061-7
43. Santegoets LA, Van SM, Heijmans-Antonissen C, et al. Reduced local immunity in HPV-related VIN: expression of chemokines and involvement of immunocompetent cells. Int J Cancer 2008; 123:616-22
44. Davidson EJ, Boswell CM, Sehr P, et al. Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins. Cancer Res 2003;63: 6032-41.