Granulocyte colony-stimulating factor off-target effect on nerve outgrowth promotes prostate cancer development

International Journal of Cancer

Volumn 136, Issue 4, 2015, Pages 982-988

  Dobrenis, Kostantin ^a   Gauthier, Laurent R ^b   Barroca, Vilma ^b   Magnon, Claire ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

Autonomic nervous system; G CSF; Hematopoietic cytokine; Tumor microenvironment

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; NERVE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FETUS; GENE EXPRESSION; IN VIVO STUDY; MALE; METASTASIS; MOUSE; NERVE FIBER GROWTH; NONHUMAN; PARASYMPATHETIC NERVE CELL; PROSTATE CANCER; TIME LAPSE IMAGING; TRANSGENIC MOUSE; TUMOR GROWTH; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; TUMOR XENOGRAFT; ADRENERGIC NERVE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CANCER TRANSPLANTATION; HL 60 CELL LINE; HUMAN; INNERVATION; METABOLISM; NERVE FIBER; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; PROSTATE; PROSTATE TUMOR;

ADRENERGIC FIBERS; ANIMALS; AXONS; CARCINOGENESIS; CELL SURVIVAL; GRANULOCYTE COLONY-STIMULATING FACTOR; HL-60 CELLS; HUMANS; MALE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; NEOPLASM TRANSPLANTATION; NERVE GROWTH FACTORS; PROSTATE; PROSTATIC NEOPLASMS;

EID: 84918794539     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29046     Document Type: Article

References (27)

1. Martino M, Fedele R, Massara E, et al. Longterm safety of granulocyte colony-stimulating factor in normal donors: Is it all clear? Expert Opin Biol Ther 2012;12:609-21
2. Martino M, Console G, Dattola A, et al. Short and long-term safety of lenograstim administration in healthy peripheral haematopoietic progenitor cell donors: A single centre experience. Bone Marrow Transplant 2009;44:163-8
3. Jeger A, Favre G, Lutz JM, et al. Tumor incidence in related hematopoietic stem cell donors. Bone Marrow Transplant 2011;46:1240-4
4. Deisseroth AB, Zu Z, Claxton D, et al. Genetic marking shows that Ph1 cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. Blood 1994;83:3068-76
5. Brugger W, Bross KJ, Glatt M, et al. Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 1994;83:636-40
6. Franklin WA, Glaspy J, Pflaumer SM, et al. Incidence of tumor-cell contamination in leukapheresis products of breast cancer patients mobilized with stem cell factor and granulocyte colonystimulating factor (G-CSF) or with G-CSF alone. Blood 1999;94:340-7
7. DiPersio JF, Ho AD, Hanrahan J, et al. Relevance and clinical implications of tumor cell mobilization in the autologous transplant setting. Biol Blood Marrow Transplant 2011;17:943-55
8. Bohlius J, Herbst C, Reiser M, et al. Granulopoiesis- stimulating factors to prevent adverse effects in the treatment of malignant lymphoma. Cochrane Database Syst Rev 2008:CD003189
9. Aapro MS, Bohlius J, Cameron DA, et al. 2010 Update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. Eur J Cancer 2011;47:8-32
10. Wang J, Yao L, Zhao S, et al. Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells. Cancer Biol Ther 2012;13:389-400
11. Kowanetz M, Wu X, Lee J, et al. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G1Ly6C1 granulocytes. Proc Natl Acad Sci USA 2010;107:21248-55
12. Hershman D, Neugut AI, Jacobson JS, et al. Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst 2007;99:196-205
13. Gridelli C, Aapro MS, Barni S, et al. Role of colony stimulating factors (CSFs) in solid tumours: Results of an expert panel. Crit Rev Oncol Hematol 2007;63:53-64
14. Rosenberg PS, Alter BP, Bolyard AA, et al. The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. Blood 2006;107:4628-35
15. Kaito K, Kobayashi M, Katayama T, et al. Longterm administration of G-CSF for aplastic anaemia is closely related to the early evolution of monosomy 7 MDS in adults. Br J Haematol 1998; 103:297-303
16. Diederich K, Sevimli S, Dorr H, et al. The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: A characterization of G-CSFdeficient mice. J Neurosc 2009;29:11572-81
17. Liu H, Jia D, Fu J, et al. Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells. Neuroscience 2009;164:1521-30
18. Jung KH, Chu K, Lee ST, et al. Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. Brain Res 2006;1073-1074: 190-201
19. Schneider A, Kruger C, Steigleder T, et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 2005;115:2083-98
20. Olar A, He D, Florentin D, et al. Biologic correlates and significance of axonogenesis in prostate cancer. Hum Pathol 2014;45:1365-9
21. Magnon C, Hall SJ, Lin J, et al. Autonomic nerve development contributes to prostate cancer progression. Science 2013;341:1236361
22. Dobrenis K, Chang HY, Pina-Benabou MH, et al. Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons. J Neurosci Res 2005;82:306-15
23. Gauthier LR, Granotier C, Hoffschir F, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci 2012;69:629-40
24. Schweizerhof M, Stosser S, Kurejova M, et al. Hematopoietic colony-stimulating factors mediate tumor-nerve interactions and bone cancer pain. Nat Med 2009;15:802-7
25. Aboody K, Capela A, Niazi N, et al. Translating stem cell studies to the clinic for CNS repair: current state of the art and the need for a Rosetta stone. Neuron 2011;70:597-613
26. Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;438:820-7
27. Hiratsuka S, Watanabe A, Aburatani H, et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 2006;8: 1369-75.