메뉴 건너뛰기




Volumn 743, Issue , 2014, Pages 1-10

Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice

Author keywords

Cachexia; Cancer; Ghrelin; Muscle atrophy

Indexed keywords

ATROGIN 1; C REACTIVE PROTEIN; FORKHEAD BOX PROTEIN O1; FORKHEAD TRANSCRIPTION FACTOR; GHRELIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MUSCLE RING FINGER 1 PROTEIN; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PROTEIN KINASE B;

EID: 84918786476     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.09.025     Document Type: Article
Times cited : (32)

References (44)
  • 2
    • 0015275622 scopus 로고
    • Work and metabolic patterns of fast and slow twitch skeletal muscle contracting in situ
    • K.M. Baldwin, and C.M. Tipton Work and metabolic patterns of fast and slow twitch skeletal muscle contracting in situ Pflug. Arch. 334 1972 345 356
    • (1972) Pflug. Arch. , vol.334 , pp. 345-356
    • Baldwin, K.M.1    Tipton, C.M.2
  • 3
    • 0024377089 scopus 로고
    • Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat
    • R.J. Bodnar, G.W. Pasternak, P.E. Mann, D. Paul, R. Warren, and D.B. Donner Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat Cancer Res. 49 1989 6280 6284
    • (1989) Cancer Res. , vol.49 , pp. 6280-6284
    • Bodnar, R.J.1    Pasternak, G.W.2    Mann, P.E.3    Paul, D.4    Warren, R.5    Donner, D.B.6
  • 4
    • 0035052711 scopus 로고    scopus 로고
    • Angiotensin II induces skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor i
    • M. Brink, S.R. Price, J. Chrast, J.L. Bailey, A. Anwar, W.E. Mitch, and P. Delafontaine Angiotensin II induces skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor I Endocrinology 142 2001 1489 1496
    • (2001) Endocrinology , vol.142 , pp. 1489-1496
    • Brink, M.1    Price, S.R.2    Chrast, J.3    Bailey, J.L.4    Anwar, A.5    Mitch, W.E.6    Delafontaine, P.7
  • 8
    • 43449104499 scopus 로고    scopus 로고
    • Cancer cachexia: Developing multimodal therapy for a multidimensional problem
    • K.C. Fearon Cancer cachexia: developing multimodal therapy for a multidimensional problem Eur. J. Cancer 44 2008 1124 1132
    • (2008) Eur. J. Cancer , vol.44 , pp. 1124-1132
    • Fearon, K.C.1
  • 9
    • 84864646651 scopus 로고    scopus 로고
    • Cancer cachexia: Mediators, signaling, and metabolic pathways
    • K.C. Fearon, D.J. Glass, and D.C. Guttridge Cancer cachexia: mediators, signaling, and metabolic pathways Cell Metab. 16 2012 153 166
    • (2012) Cell Metab. , vol.16 , pp. 153-166
    • Fearon, K.C.1    Glass, D.J.2    Guttridge, D.C.3
  • 10
    • 84874083358 scopus 로고    scopus 로고
    • Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: A multicenter, randomized, double-blind, crossover, pilot study
    • J.M. Garcia, J. Friend, and S. Allen Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study Support. Care Cancer 21 2013 129 137
    • (2013) Support. Care Cancer , vol.21 , pp. 129-137
    • Garcia, J.M.1    Friend, J.2    Allen, S.3
  • 12
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 14
    • 84900563749 scopus 로고    scopus 로고
    • Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle
    • J.M. Kristensen, J.T. Treebak, P. Schjerling, L. Goodyear, and J.F. Wojtaszewski Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle Am. J. Physiol. Endocrinol. Metab. 306 2014 E1099 E1109
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. 1099-E1109
    • Kristensen, J.M.1    Treebak, J.T.2    Schjerling, P.3    Goodyear, L.4    Wojtaszewski, J.F.5
  • 16
    • 0242691782 scopus 로고    scopus 로고
    • Cancer anorexia: Clinical implications, pathogenesis, and therapeutic strategies
    • A. Laviano, M.M. Meguid, and F. Rossi-Fanelli Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies Lancet Oncol. 4 2003 686 694
    • (2003) Lancet Oncol. , vol.4 , pp. 686-694
    • Laviano, A.1    Meguid, M.M.2    Rossi-Fanelli, F.3
  • 17
    • 14644400387 scopus 로고    scopus 로고
    • TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
    • Y.P. Li, Y. Chen, J. John, J. Moylan, B. Jin, D.L. Mann, and M.B. Reid TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle FASEB J. 19 2005 362 370
    • (2005) FASEB J. , vol.19 , pp. 362-370
    • Li, Y.P.1    Chen, Y.2    John, J.3    Moylan, J.4    Jin, B.5    Mann, D.L.6    Reid, M.B.7
  • 18
    • 0030888377 scopus 로고    scopus 로고
    • Mechanisms of host wasting induced by administration of cytokines in rats
    • P.R. Ling, J.H. Schwartz, and B.R. Bistrian Mechanisms of host wasting induced by administration of cytokines in rats Am. J. Physiol. 272 1997 E333 E339
    • (1997) Am. J. Physiol. , vol.272 , pp. 333-E339
    • Ling, P.R.1    Schwartz, J.H.2    Bistrian, B.R.3
  • 19
    • 0020531450 scopus 로고
    • Major effect on susceptibility to urethan-induced pulmonary adenoma by a single gene in BALB/cBy mice
    • A.M. Malkinson, and D.S. Beer Major effect on susceptibility to urethan-induced pulmonary adenoma by a single gene in BALB/cBy mice J. Natl. Cancer Inst. 70 1983 931 936
    • (1983) J. Natl. Cancer Inst. , vol.70 , pp. 931-936
    • Malkinson, A.M.1    Beer, D.S.2
  • 20
    • 0031835510 scopus 로고    scopus 로고
    • Cytokine activity in cancer-related anorexia/cachexia: Role of megestrol acetate and medroxyprogesterone acetate
    • G. Mantovani, A. Maccio, P. Lai, E. Massa, M. Ghiani, and M.C. Santona Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate Semin. Oncol. 25 1998 45 52
    • (1998) Semin. Oncol. , vol.25 , pp. 45-52
    • Mantovani, G.1    Maccio, A.2    Lai, P.3    Massa, E.4    Ghiani, M.5    Santona, M.C.6
  • 21
    • 23444461754 scopus 로고    scopus 로고
    • PTEN expression in non-small-cell lung cancer: Evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
    • C.J. Marsit, S. Zheng, K. Aldape, P.W. Hinds, H.H. Nelson, J.K. Wiencke, and K.T. Kelsey PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration Hum. Pathol. 36 2005 768 776
    • (2005) Hum. Pathol. , vol.36 , pp. 768-776
    • Marsit, C.J.1    Zheng, S.2    Aldape, K.3    Hinds, P.W.4    Nelson, H.H.5    Wiencke, J.K.6    Kelsey, K.T.7
  • 24
    • 20844460120 scopus 로고    scopus 로고
    • Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    • N. Nagaya, J. Moriya, Y. Yasumura, M. Uematsu, F. Ono, W. Shimizu, K. Ueno, M. Kitakaze, K. Miyatake, and K. Kangawa Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure Circulation 110 2004 3674 3679
    • (2004) Circulation , vol.110 , pp. 3674-3679
    • Nagaya, N.1    Moriya, J.2    Yasumura, Y.3    Uematsu, M.4    Ono, F.5    Shimizu, W.6    Ueno, K.7    Kitakaze, M.8    Miyatake, K.9    Kangawa, K.10
  • 25
    • 0035908954 scopus 로고    scopus 로고
    • Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    • N. Nagaya, M. Uematsu, M. Kojima, Y. Ikeda, F. Yoshihara, W. Shimizu, H. Hosoda, Y. Hirota, H. Ishida, H. Mori, and K. Kangawa Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430 1435
    • (2001) Circulation , vol.104 , pp. 1430-1435
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3    Ikeda, Y.4    Yoshihara, F.5    Shimizu, W.6    Hosoda, H.7    Hirota, Y.8    Ishida, H.9    Mori, H.10    Kangawa, K.11
  • 26
    • 84881258990 scopus 로고    scopus 로고
    • Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model
    • R. Northrup, K. Kuroda, E.M. Duus, S.R. Barnes, L. Cheatham, T. Wiley, and C. Pietra Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model Support. Care Cancer 21 2013 2409 2415
    • (2013) Support. Care Cancer , vol.21 , pp. 2409-2415
    • Northrup, R.1    Kuroda, K.2    Duus, E.M.3    Barnes, S.R.4    Cheatham, L.5    Wiley, T.6    Pietra, C.7
  • 27
    • 0036677403 scopus 로고    scopus 로고
    • Early restriction of peripheral and proximal cell lineages during formation of the lung
    • A.K. Perl, S.E. Wert, A. Nagy, C.G. Lobe, and J.A. Whitsett Early restriction of peripheral and proximal cell lineages during formation of the lung Proc. Natl. Acad. Sci. USA. 99 2002 10482 10487
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , pp. 10482-10487
    • Perl, A.K.1    Wert, S.E.2    Nagy, A.3    Lobe, C.G.4    Whitsett, J.A.5
  • 28
    • 0017367461 scopus 로고
    • The distribution and relative sizes of three histochemical fibre types in the rat tibialis anterior muscle
    • A.H. Pullen The distribution and relative sizes of three histochemical fibre types in the rat tibialis anterior muscle J. Anat. 123 1977 1 19
    • (1977) J. Anat. , vol.123 , pp. 1-19
    • Pullen, A.H.1
  • 29
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and meta-regression analysis
    • A.G. Renehan, M. Zwahlen, C. Minder, S.T. O'Dwyer, S.M. Shalet, and M. Egger Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis Lancet 363 2004 1346 1353
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3    O'Dwyer, S.T.4    Shalet, S.M.5    Egger, M.6
  • 30
    • 0031717379 scopus 로고    scopus 로고
    • Inducible gene targeting in mice using the Cre/lox system
    • B. Sauer Inducible gene targeting in mice using the Cre/lox system Methods 14 1998 381 392
    • (1998) Methods , vol.14 , pp. 381-392
    • Sauer, B.1
  • 31
    • 14844336534 scopus 로고    scopus 로고
    • Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting
    • Y.H. Song, Y. Li, J. Du, W.E. Mitch, N. Rosenthal, and P. Delafontaine Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting J. Clin. Invest. 115 2005 451 458
    • (2005) J. Clin. Invest. , vol.115 , pp. 451-458
    • Song, Y.H.1    Li, Y.2    Du, J.3    Mitch, W.E.4    Rosenthal, N.5    Delafontaine, P.6
  • 33
    • 84865389436 scopus 로고    scopus 로고
    • Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice
    • M. Sugiyama, A. Yamaki, M. Furuya, N. Inomata, Y. Minamitake, K. Ohsuye, and K. Kangawa Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice Regul. Pept. 178 2012 21 28
    • (2012) Regul. Pept. , vol.178 , pp. 21-28
    • Sugiyama, M.1    Yamaki, A.2    Furuya, M.3    Inomata, N.4    Minamitake, Y.5    Ohsuye, K.6    Kangawa, K.7
  • 35
    • 31344479312 scopus 로고    scopus 로고
    • Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
    • J.M. Tang, Q.Y. He, R.X. Guo, and X.J. Chang Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis Lung Cancer 51 2006 181 191
    • (2006) Lung Cancer , vol.51 , pp. 181-191
    • Tang, J.M.1    He, Q.Y.2    Guo, R.X.3    Chang, X.J.4
  • 37
    • 0036830917 scopus 로고    scopus 로고
    • Cachexia in cancer patients
    • M.J. Tisdale Cachexia in cancer patients Nat. Rev. Cancer 2 2002 862 871
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 862-871
    • Tisdale, M.J.1
  • 38
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • M. Tschop, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 40
    • 0027471741 scopus 로고
    • Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice
    • S.E. Wert, S.W. Glasser, T.R. Korfhagen, and J.A. Whitsett Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice Dev. Biol. 156 1993 426 443
    • (1993) Dev. Biol. , vol.156 , pp. 426-443
    • Wert, S.E.1    Glasser, S.W.2    Korfhagen, T.R.3    Whitsett, J.A.4
  • 41
    • 39149139958 scopus 로고    scopus 로고
    • GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1
    • D. Yamamoto, N. Ikeshita, T. Matsubara, H. Tasaki, E.H. Herningtyas, K. Toda, K. Iida, Y. Takahashi, H. Kaji, K. Chihara, and Y. Okimura GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1 Life Sci. 82 2008 460 466
    • (2008) Life Sci. , vol.82 , pp. 460-466
    • Yamamoto, D.1    Ikeshita, N.2    Matsubara, T.3    Tasaki, H.4    Herningtyas, E.H.5    Toda, K.6    Iida, K.7    Takahashi, Y.8    Kaji, H.9    Chihara, K.10    Okimura, Y.11
  • 43
    • 0142089853 scopus 로고    scopus 로고
    • Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats
    • T. Yasuda, T. Masaki, T. Kakuma, and H. Yoshimatsu Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats Neurosci. Lett. 349 2003 75 78
    • (2003) Neurosci. Lett. , vol.349 , pp. 75-78
    • Yasuda, T.1    Masaki, T.2    Kakuma, T.3    Yoshimatsu, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.