Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance

European Journal of Nutrition

Volumn 53, Issue 7, 2014, Pages 1445-1456

  Rauh Pfeiffer, Astrid ^a   Handel, Uschi ^a   Demmelmair, Hans ^a   Peissner, Wolfgang ^a   Niesser, Mareile ^a   Moretti, Diego ^b,c   Martens, Vanessa ^b   Wiseman, Sheila ^b   Weichert, Judith ^d   Heene, Moritz ^d   Bühner, Markus ^d   Koletzko, Berthold ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^c ETH ZURICH   (Switzerland)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

B vitamin supplementation; Cognition; Pre school children

Indexed keywords

CALCIUM; CREATININE; CYANOCOBALAMIN; FOLIC ACID; HEMOGLOBIN; HOMOCYSTEINE; METHYLMALONIC ACID; PYRIDOXINE; RIBOFLAVIN; BIOLOGICAL MARKER; CALCIUM INTAKE; VITAMIN B COMPLEX;

ARTICLE; BLOOD SAMPLING; CHILD; COGNITION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SHORT TERM MEMORY; VITAMIN SUPPLEMENTATION; WECHSLER INTELLIGENCE SCALE; ADMINISTRATION AND DOSAGE; BLOOD; CALCIUM INTAKE; DIET SUPPLEMENTATION; DRUG EFFECTS; GERMANY; URINE;

BIOLOGICAL MARKERS; CALCIUM, DIETARY; CHILD; CHILD, PRESCHOOL; COGNITION; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FOLIC ACID; GERMANY; HOMOCYSTEINE; HUMANS; MALE; MEMORY, SHORT-TERM; METHYLMALONIC ACID; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 84918769307     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-013-0647-y     Document Type: Article

References (52)

1. Bryan J, Osendarp S, Hughes D, Calvaresi E, Baghurst K, van Klinken JW (2004) Nutrients for cognitive development in school-aged children. Nutr Rev 62:295–306
2. Bailey LB, Gregory JF III (1999) Folate metabolism and requirements. J Nutr 129:779–782
3. Crowe SF, Ross CK (1997) Effect of folate deficiency and folate and B12 excess on memory functioning in young chicks. Pharmacol Biochem Behav 56:189–197
4. Troen AM, Shukitt-Hale B, Chao WH, Albuquerque B, Smith DE, Selhub J, Rosenberg J (2006) The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice. J Alzheimers Dis 9:381–392
5. Lalonde R, Barraud H, Ravey J, Gueant JL, Bronowicki JP, Strazielle C (2008) Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice. Brain Res 1188:122–131. doi:10.1016/j.brainres.2007.10.068
6. Arija V, Esparó G, Fernández-Ballart J, Murphy MM, Biarnés E, Canals J (2006) Nutritional status and performance in test of verbal and non-verbal intelligence in 6 year old children. Intelligence 34:141–149. doi:10.1016/j.intell.2005.09.001
7. Strand TA, Taneja S, Ueland PM, Refsum H, Bahl R, Schneede J, Sommerfelt H, Bhandari N (2013) Cobalamin and folate status predicts mental development scores in North Indian children 12–18 mo of age. Am J Clin Nutr 97:310–317. doi:10.3945/ajcn.111.032268
8. Bryan J, Calvaresi E, Hughes D (2002) Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr 132:1345–1356
9. Louwman MW, van Dusseldorp M, van de Vijver FJ, Thomas CM, Schneede J, Ueland PM, Refsum H, van Staveren WA (2000) Signs of impaired cognitive function in adolescents with marginal cobalamin status. Am J Clin Nutr 72:762–769
10. Gewa CA, Weiss RE, Bwibo NO, Whaley S, Sigman M, Murphy SP, Harrison G, Neumann CG (2009) Dietary micronutrients are associated with higher cognitive function gains among primary school children in rural Kenya. Br J Nutr 101:1378–1387. doi:10.1017/S0007114508066804
11. Homocysteine Lowering Trialists’ Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 316:894–898
12. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, Genest J Jr (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 354:1567–1577. doi:10.1056/NEJMoa060900
13. Ueland PM, Monsen AL (2003) Hyperhomocysteinemia and B-vitamin deficiencies in infants and children. Clin Chem Lab Med 41:1418–1426. doi:10.1515/CCLM.2003.218
14. Sichert-Hellert W, Wenz G, Kersting M (2006) Vitamin intakes from supplements and fortified food in German children and adolescents: results from the DONALD study. J Nutr 136:1329–1333
15. Mensink GBE, Herseker H, Richter A, Stahl A, Vohmann C (2007) Ernährungstudie als KIGGS-Modul (EsKiMo), German [KIGGS nutrition survey]. In: Robert Koch Institut and Universität Paderborn, Berlin and Paderborn
16. Wolfe JM, Bailey LB, Herrlinger-Garcia K, Theriaque DW, Gregory JF III, Kauwell GP (2003) Folate catabolite excretion is responsive to changes in dietary folate intake in elderly women. Am J Clin Nutr 77:919–923
17. Kim HA, Choi JH, Lim HS (2007) Childbearing women of twenty and under are at greater risk than those of twenty-five and over for compromised folate status. Nutr Res Pract 1:254–259. doi:10.4162/nrp.2007.1.4.254
18. Moher D, Schulz KF, Altman D (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA 285:1987–1991
19. Scientific Committee on Food & Scientific Panel on Dietetic Products Nutrition and Allergies (2006) Tolerable upper intake levels for vitamins and minerals. In: European Food Safety Authority
20. Ricken G, Fritz A, Schuck KD, Preuß U (eds) (2007) HAWIVA-III, Hannover-Wechsler-Intelligenztest für das Vorschulalter-III, German [HAWIVA-III, Hannover-Wechsler-Preschool Scale of Intelligence-III]. Huber, Göttingen
21. Wechsler D (2002) Wechsler Preschool and Primary Scale of Intelligence-III (WPPSI-III). The Psychological Corporation, San Antonio, TX
22. Kaufman AS, Kaufman NL (1983) Kaufman assessment battery for children: K-ABC. American Guidance Service, Circle Pines, MN
23. Melchers P, Preuß U (2005) Kaufman assessment battery for children. Pearson Assessment, Frankfurt/Main
24. Bartels H, Böhmer M, Heierli C (1972) Serum kreatininbestimmung ohne enteiweissen, German [Serum creatinine determination without protein precipitation]. Clin Chim Acta 37:193–197. doi:10.1016/0009-8981(72)90432-9
25. Niesser M, Harder U, Koletzko B, Peissner W (2013) Quantification of urinary folate catabolites using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 929:116–124. doi:10.1016/j.jchromb.2013.04.008
26. Matchar DB, Feussner JR, Millington DS, Wilkinson RH Jr, Watson DJ, Gale D (1987) Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. Ann Intern Med 106:707–710
27. O’Broin S, Kelleher B (1992) Microbiological assay on microtitre plates of folate in serum and red cells. J Clin Pathol 45:344–347
28. Heuck CC, Reinauer H, Wood WG (2008) The alkaline haematin detergent (AHD575) method for the determination of haemoglobin in blood–a candidate reference measurement procedure. Clin Lab 54:255–272
29. Hellmuth C, Koletzko B, Peissner W (2011) Aqueous normal phase chromatography improves quantification and qualification of homocysteine, cysteine and methionine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 879:83–89. doi:10.1016/j.jchromb.2010.11.016
30. Huemer M, Vonblon K, Fodinger M, Krumpholz R, Hubmann M, Ulmer H, Simma B (2006) Total homocysteine, folate, and cobalamin, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents. Pediatr Res 60:764–769. doi:10.1203/01.pdr.0000246099.39469.18
31. R Development Core Team (2010) R: A language and environment for statistical computing. In: R Foundation for Statistical Computing, Vienna, Austria
32. Heseker H, Kuebler W, Westenhoefer J, Pudel V (1990) Psychische Veraenderungen als Fruehzeichen einer suboptimalen Vitaminversorgung, German [Psychic changes as early symptoms of suboptimal vitamin supply]. 2. Ernaehrungs-Umschau 37:87–94
33. Haskell CF, Scholey AB, Jackson PA, Elliott JM, Defeyter MA, Greer J, Robertson BC, Buchanan T, Tiplady B, Kennedy DO (2008) Cognitive and mood effects in healthy children during 12 weeks’ supplementation with multi-vitamin/minerals. Br J Nutr 100:1086–1096. doi:10.1017/S0007114508959213
34. Osendarp SJ, Baghurst KI, Bryan J, Calvaresi E, Hughes D, Hussaini M, Karyadi SJ, van Klinken BJ, van der Knaap HC, Lukito W, Mikarsa W, Transler C, Wilson C (2007) Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. Am J Clin Nutr 86:1082–1093
35. Durga J, Verhoef P, Anteunis LJ, Schouten E, Kok FJ (2007) Effects of folic acid supplementation on hearing in older adults: a randomized, controlled trial. Ann Intern Med 146:1–9
36. Vogel T, Dali-Youcef N, Kaltenbach G, Andres E (2009) Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. Int J Clin Pract 63:1061–1067. doi:10.1111/j.1742-1241.2009.02026.x
37. Fabian E, Bogner M, Kickinger A, Wagner KH, Elmadfa I (2011) Intake of medication and vitamin status in the elderly. Ann Nutr Metab 58:118–125. doi:10.1159/000327351
38. Mansoor MA, Hervig T, Stakkestad JA, Drablos PA, Apeland T, Wentzel-Larsen T, Bates CJ (2011) Serum folate is significantly correlated with plasma cysteine concentrations in healthy industry workers. Ann Nutr Metab 58:68–73. doi:10.1159/000325537
39. O’Broin SD, Kelleher BP, Davoren A, Gunter EW (1997) Field-study screening of blood folate concentrations: specimen stability and finger-stick sampling. Am J Clin Nutr 66:1398–1405
40. Kerr MA, Livingstone B, Bates CJ, Bradbury I, Scott JM, Ward M, Pentieva K, Mansoor MA, McNulty H (2009) Folate, related B vitamins, and homocysteine in childhood and adolescence: potential implications for disease risk in later life. Pediatrics 123:627–635. doi:10.1542/peds.2008-1049
41. Pfeiffer CM, Johnson CL, Jain RB, Yetley EA, Picciano MF, Rader JI, Fisher KD, Mulinare J, Osterloh JD (2007) Trends in blood folate and vitamin B-12 concentrations in the United States, 1988 2004. Am J Clin Nutr 86:718–727
42. Roza SJ, van Batenburg-Eddes T, Steegers EA, Jaddoe VW, Mackenbach JP, Hofman A, Verhulst FC, Tiemeier H (2010) Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study. Br J Nutr 103:445–452. doi:10.1017/S0007114509991954
43. Nguyen CT, Gracely EJ, Lee BK (2013) Serum folate but not vitamin B-12 concentrations are positively associated with cognitive test scores in children aged 6–16 years. J Nutr 143:500–504. doi:10.3945/jn.112.166165
44. Bjorke-Monsen AL, Torsvik I, Saetran H, Markestad T, Ueland PM (2008) Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation. Pediatrics 122:83–91. doi:10.1542/peds.2007-2716
45. Torsvik I, Ueland PM, Markestad T, Bjorke-Monsen AL (2013) Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study. Am J Clin Nutr 98:1233–1240. doi:10.3945/ajcn.113.061549
46. Homocysteine Lowering Trialists’ Collaboration (2005) Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 82:806–812
47. Chew SC, Khor GL, Loh SP (2011) Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults. J Nutr Sci Vitaminol (Tokyo) 57:150–155
48. Erdogan E, Nelson GJ, Rockwood AL, Frank EL (2010) Evaluation of reference intervals for methylmalonic acid in plasma/serum and urine. Clin Chim Acta 411:1827–1829. doi:10.1016/j.cca.2010.06.017
49. Bjorke Monsen AL, Ueland PM (2003) Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence. Am J Clin Nutr 78:7–21
50. Stanger O, Herrmann W, Pietrzik K, Fowler B, Geisel J, Dierkes J, Weger M, e.V D-LH (2003) DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations. Clin Chem Lab Med 41:1392–1403. doi:10.1515/CCLM.2003.214
51. Lentze MJ, Schaub J, Schulte FJ, Spranger J (2007) Pädiatrie: Grundlagen und Praxis, German [Pediatrics: Basics and practice]. In: Springer Medizin Verlag Heidelberg, Berlin, Heidelberg
52. Statistisches Bundesamt (ed) (2011) Statistisches Jahrbuch 2011, German [statistical yearbook 2011]. Statistisches Bundesamt, Wiesbaden