Evaluation of reference intervals for methylmalonic acid in plasma/serum and urine

Clinica Chimica Acta

Volumn 411, Issue 21-22, 2010, Pages 1827-1829

  Erdogan, Evrim ^a   Nelson, Gordon J ^b   Rockwood, Alan L ^a   Frank, Elizabeth L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b ARUP LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLMALONIC ACID;

AGE DISTRIBUTION; BLOOD ANALYSIS; BLOOD LEVEL; BLOOD SAMPLING; DIAGNOSTIC ACCURACY; HUMAN; ISOTOPE DILUTION ASSAY; LETTER; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REFERENCE VALUE; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE LEVEL;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; METHYLMALONIC ACID; MIDDLE AGED; REFERENCE VALUES; YOUNG ADULT;

EID: 77956488432     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.06.017     Document Type: Letter

References (20)

1. Cox E.V., White A.M. Methylmalonic acid excretion: an index of vitamin-B12 deficiency. Lancet 1962, 2:853-856.
2. Klee G.G. Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B12 and folate. Clin Chem 2000, 46:1277-1283.
3. Shenkin A., Baines M., Fell G.S., et al. Vitamins and trace elements. Tietz textbook of clinical chemistry and molecular diagnostics 2006, 1075-1164. Elsevier Saunders, St. Louis. C.A. Burtis, E.R. Ashwood, D.E. Bruns (Eds.).
4. Lindenbaum J., Savage D.G., Stabler S., Allen R.H. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 1990, 34:99-107.
5. Moelby L., Rasmussen K., Jensen M.K., Pedersen K.O. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid. J Intern Med 1990, 228:373-378.
6. Marcell P.D., Stabler S.P., Podell E.R., Allen R.H. Quantitation of methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1985, 150:58-66.
7. Rasmussen K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989, 35:260-264.
8. Rasmussen K., Moelby L., Jensen M.K. Studies on methylmalonic acid in humans. II. Relationship between concentrations in serum and urinary excretion, and the correlation between serum cobalamin and accumulation of methylmalonic acid. Clin Chem 1989, 35:2277-2280.
9. Rasmussen K., Moller J., Ostergaard K., Kristensen M.O., Jensen J. Methylmalonic acid concentrations in serum of normal subjects: biological variability and effect of oral l-isoleucine loads before and after intramuscular administration of cobalamin. Clin Chem 1990, 36:1295-1299.
10. Windelberg A., Arseth O., Kvalheim G., Ueland P.M. Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem 2005, 51:2103-2109.
11. Komaromy-Hiller G., Ash K.O., Costa R., Howerton K. Comparison of representative ranges based on U.S. patient population and literature reference intervals for urinary trace elements. Clin Chim Acta 2000, 296:71-90.
12. Kushnir M.M., Komaromy-Hiller G., Shushan B., Urry F.M., Roberts W.L. Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine. Clin Chem 2001, 47:1993-2002.
13. Kushnir M.M., Rockwood A.L., Nelson G.J. Simultaneous quantitative analysis of isobars by tandem mass spectrometry from unresolved chromatographic peaks. J Mass Spectrom 2004, 39:532-540.
14. National Kidney Disease Education Program (NKDEP). http://www.nkdep.nih.gov/labprofessionals/Clinical_Laboratories.htm (Accessed May 2010).
15. Clinical and Laboratory Standards Institute Defining, establishing, and verifying reference intervals in the clinical laboratory; approved guideline. CLSI document C28-A3 2008, Clinical Laboratory Standards Institute, Wayne, PA. Third edition.
16. Fenton W.A., Gravel R.A., Rosenblatt D.S. Disorders of propionate and methylmalonate metabolism. The metabolic & molecular bases of inherited disease 2001, 2165-2193. McGraw-Hill, New York. 8th ed. C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.).
17. Lindenbaum J., Rosenberg I.H., Wilson P.W., Stabler S.P., Allen R.H. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994, 60:2-11.
18. Horn P.S., Feng L., Li Y., Pesce A.J. Effect of outliers and nonhealthy individuals on reference interval estimation. Clin Chem 2001, 47:2137-2145.
19. Hoffmann R.G. Statistics in the practice of medicine. JAMA 1963, 185:864-873.
20. Bock B.J., Dolan C.T., Miller G.C., et al. The data warehouse as a foundation for population-based reference intervals. Am J Clin Pathol 2003, 120:662-670.