Tipping the MYC-MIZ1 balance: Targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes

EMBO Molecular Medicine

Volumn 6, Issue 12, 2014, Pages 1509-1511

  Schaub, Franz X ^a   Cleveland, John L ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MIZ1 PROTEIN; MYC PROTEIN; ONCOPROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE HUWE1; UNCLASSIFIED DRUG; MOLECULAR LIBRARY;

CANCER CELL; CANCER GROWTH; CELL CYCLE ARREST; CELL GROWTH; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; HUMAN; NOTE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN TARGETING; SOMATIC MUTATION; TUMOR REGRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; COLORECTAL TUMOR; ENZYMOLOGY; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY;

ANIMALS; COLORECTAL NEOPLASMS; HUMANS; ONCOGENE PROTEIN P55(V-MYC); SMALL MOLECULE LIBRARIES; UBIQUITIN-PROTEIN LIGASES;

EID: 84918588909     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404735     Document Type: Note

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