Tumorigenic risk of human induced pluripotent stem cell explants cultured on mouse SNL76/7 feeder cells

Biochemical and Biophysical Research Communications

Volumn 453, Issue 3, 2014, Pages 668-673

  Kamada, Mizuna ^a   Mitsui, Youji ^a   Kumazaki, Tsutomu ^a   Kawahara, Yuta ^a   Matsuo, Taira ^a   Takahashi, Tomoko ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Cell transplantation; Human iPS cells; SNL76 7 feeder cell; Tumor formation

Indexed keywords

MITOMYCIN;

ANGIOSARCOMA; ANIMAL CELL; ARTICLE; CANCER CELL; CANCER GENETICS; CANCER RISK; CARCINOGENESIS; CELL CULTURE; CELL FUSION; CELL TRANSPLANTATION; CONTROLLED STUDY; EXPLANT; FEEDER CELL; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; SOLITARY FIBROUS TUMOR; TERATOMA; ANIMAL; CELL LINE; CYTOLOGY; EXPERIMENTAL NEOPLASM; GENE EXPRESSION PROFILING; METABOLISM; PATHOLOGY; SCID MOUSE; STEM CELL TRANSPLANTATION;

IPS; MUS;

ANIMALS; CARCINOGENESIS; CELL LINE; FEEDER CELLS; GENE EXPRESSION PROFILING; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, SCID; NEOPLASMS, EXPERIMENTAL; STEM CELL TRANSPLANTATION;

EID: 84918567810     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.10.009     Document Type: Article

References (15)

1. J. Yu, M.A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J.L. Frane, S. Tian, J. Nie, G.A. Jonsdottir, V. Ruotti, R. Stewart, I.I. Slukvin, J.A. Thomson, Induced pluripotent stem cell lines derived from human somatic cells, Science 318 (2007) 1917-1920.
2. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, S. Yamanaka, Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell 131 (2007) 861-872.
3. K. Miura, Y. Okada, T. Aoi, A. Okada, K. Takahashi, K. Okita, M. Nakagawa, M. Koyanagi, K. Tanabe, M. Ohnuki, D. Ogawa, E. Ikeda, H. Okano, S. Yamanaka, Variation in the safety of induced pluripotent stem cell lines, Nat. Biotechnol. 27 (2009) 743-745.
4. A. Yamashita, S. Liu, K. Woltjen, B. Thomas, G. Meng, A. Hotta, K. Takahashi, J. Ellis, S. Yamanaka, D.E. Rancourt, Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells, Sci. Rep. 3 (2013) 1978.
5. V. Akopian, P.W. Andrews, S. Beil, N. Benvenisty, J. Brehm, M. Christie, A. Ford, V. Fox, P.J. Gokhale, L. Healy, F. Holm, O. Hovatta, B.B. Knowles, T.E. Ludwig, R.D. McKay, T. Miyazaki, N. Nakatsuji, S.K. Oh, M.F. Pera, J. Rossant, G.N. Stacey, H. Suemori, Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells, Vitro Cell Dev. Biol. Anim. 46 (2010) 247-258.
6. S. Yamasaki, Y. Taguchi, A. Shimamoto, H. Mukasa, H. Tahara, T. Okamoto, Generation of human induced pluripotent stem (Ips) cells in serum- and feeder-free defined culture and TGF-Beta1 regulation of pluripotency, PLoS One 9 (2014) e87151.
7. M. Tomasz, Mitomycin C: small, fast and deadly (but very selective), Chem. Biol. 2 (1995) 575-579.
8. A.P. McMahon, A. Bradley, The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain, Cell 62 (1990) 1073-1085.
9. M. Ohashi, S. Aizawa, H. Ooka, T. Ohsawa, K. Kaji, H. Kondo, T. Kobayashi, T. Noumura, M. Matsuo, Y. Mitsui, S. Murota, K. Yamamoto, H. Ito, H. Shimada, T. Utakoji, A new human diploid cell strain, TIG-1, for the research on cellular aging, Exp. Gerontol. 15 (1980) 121-133.
10. M. Kamada, T. Kumazaki, T. Matsuo, Y. Mitsui, T. Takahashi, Establishment of ultra long-lived cell lines by transfection of TERT into normal human fibroblast TIG-1 and their characterization, Cell Biol. Int. 36 (2012) 519-527.
11. T. Kumazaki, S. Kurata, T. Matsuo, Y. Mitsui, T. Takahashi, Establishment of human induced pluripotent stem cell lines from normal fibroblast TIG-1, Hum. Cell 24 (2011) 96-103.
12. T. Kumazaki, T. Takahashi, T. Matsuo, M. Kamada, Y. Mitsui, Re-emergence of undifferentiated cells from transplants of human induced pluripotent stem cells as a possible risk factor of tumourigenesis, Cell Biol. Int. Rep. 21 (2014) 17-24.
13. C.A. Cowan, J. Atienza, D.A. Melton, K. Eggan, Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells, Science 309 (2005) 1369-1373.
14. Y. Bi, D. Mukhopadhyay, M. Drinane, B. Ji, X. Li, S. Cao, V.H. Shah, Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics, Am. J. Physiol. Cell Physiol. (2014).
15. D. Kim, C.H. Kim, J.I. Moon, Y.G. Chung, M.Y. Chang, B.S. Han, S. Ko, E. Yang, K.Y. Cha, R. Lanza, K.S. Kim, Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins, Cell Stem Cell 4 (2009) 472-476.