Factors associated with short-term changes in HIV viral load and CD4+ cell count in antiretroviral-naive individuals

AIDS

Volumn 28, Issue 9, 2014, Pages 1351-1356

  Nakagawa, Fumiyo ^a   Lodwick, Rebecca ^a   Smith, Colette ^a   Costagliola, Dominique ^a   Van Sighem, Ard ^a   Ledergerber, Bruno ^a   Monforte, Antonella D'Arminio ^a   Dorrucci, Maria ^a   Torti, Carlo ^a   Suarez Lozano, Ignacio ^a   Obel, Niels ^a   Brockmeyer, Norbert ^a   Thiebaut, Rodolphe ^a   Lundgren, Jens ^a   Castagna, Antonella ^a   Alejos, Belén ^a   De Wit, Stéphane ^a   Zangerle, Robert ^a   Pantazis, Nikos ^a   Ehren, Kathrin ^a   Casabona, Jordi ^a   Grarup, Jesper ^a   Chêne, Geneviève ^a   Phillips, Andrew ^a   more..

^a NONE

Author keywords

Antiretroviral naive; CD4+ lymphocyte count; HIV; HIV viral load

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; ASSOCIATION; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; DATA BASE; FEMALE; HETEROSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ABUSE; MAJOR CLINICAL STUDY; MALE; MEN WHO HAVE SEX WITH MEN; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RACE; VIRUS LOAD; VIRUS TRANSMISSION; ADOLESCENT; AGE; AGED; DISEASE COURSE; EUROPE; IMMUNOLOGY; MIDDLE AGED; TIME; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; DISEASE PROGRESSION; EUROPE; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; TIME FACTORS; VIRAL LOAD; YOUNG ADULT;

EID: 84918551768     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000224     Document Type: Article

References (15)

1. Sabin CA, Devereux H, Phillips AN, Hill A, Janossy G, Lee CA, et al. Course of viral load throughout HIV-1 infection. J Acquir Immune Defic Syndr 2000; 23:172-177.
2. Mellors JW, Munoz A, Giorgi JV, Margolick JB, Tassoni CJ, Gupta P, et al. Plasma viral load and CD4R lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997; 126:946-954.
3. Lyles RH, Munoz A, Yamashita TE, Bazmi H, Detels R, Rinaldo CR, et al. Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. J Infect Dis 2000; 181:872-880.
4. Phillips AN, Lee CA, Elford J, Janossy G, Timms A, Bofill M, et al. Serial lymphocyte CD4 counts and development of AIDS. Lancet 1991; 337:389-392.
5. CASCADE Collaboration. Short-term risk of AIDS according to current CD4 cell count and viral load in antiretroviral drugnaive individuals and those treated in the monotherapy era. AIDS 2004; 18:51-58.
6. Goujard C, Bonarek M, Meyer L, Bonnet F, Chaix ML, Deveau C, et al. CD4 cell count and HIV DNA level are independent predictors of disease progression after primary HIV type 1 infection in untreated patients. Clin Infect Dis 2006; 42:709-715.
7. Langford S, Ananworanich J, Cooper D. Predictors of disease progressioninHIVinfection: a review. AIDSRes Ther2007; 4:11.
8. Cambiano V, Phillips AN. Modelling the impact of treatment with individual antiretrovirals. Curr Opin HIV AIDS 2011; 6:124-130.
9. Phillips AN, Sabin C, Pillay D, Lundgren JD. HIV in the UK 1980-2006: reconstruction using a model of HIV infection and the effect of antiretroviral therapy. HIV Med 2007; 8:536-546.
10. The Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study group. Response to combination antiretroviral therapy: variation by age. AIDS 2008; 22:1463-1473.
11. Phillips AN, Lampe FC, Smith CJ, Geretti AM, Rodger A, Lodwick RK, et al. Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletion. AIDS 2010; 24:1561-1567.
12. Touloumi G, Pantazis N, Babiker AG, Walker SA, Katsarou O, Karafoulidou A, et al. Differences in HIV RNA levels before the initiation of antiretroviral therapy among 1864 individuals with known HIV-1 seroconversion dates. AIDS 2004; 18:1697-1705.
13. Rodriguez B, Sethi AK, Cheruvu VK, Mackay W, Bosch RJ, Kitahata M, et al. Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection. JAMA 2006; 296:1498-1506.
14. Touloumi G, Hatzakis A, Rosenberg PS, O'Brien TR, Goedert JJ. Effects of age at seroconversion and baseline HIV RNA level on the loss of CD4R cells among persons with hemophilia. AIDS 1998; 12:1691-1697.
15. Malone JL, Simms TE, Gray GC, Wagner KF, Burge JR, Burke DS. Sources of variability in repeated T-helper lymphocyte counts from human immunodeficiency virus type 1-infected patients - total lymphocyte count fluctuations and diurnal cycle are important. J Acquir Immune Defic Syndr Hum Retrovirol 1990; 3:144-151.