Antipsychotic use in elderly patients and the risk of pneumonia

Expert Opinion on Drug Safety

Volumn 14, Issue 1, 2015, Pages 1-6

  Gambassi, Giovanni ^a   Sultana, Janet ^b   Trifirò, Gianluca ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Antipsychotics; Behavioral disorders; Dementia; Elderly; Observational studies; Pneumonia

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; NEUROLEPTIC AGENT;

DRUG EFFICACY; HOSPITALIZATION; HUMAN; PNEUMONIA; REVIEW; RISK BENEFIT ANALYSIS; AGED; CHEMICALLY INDUCED; RISK FACTOR;

AGED; ANTIPSYCHOTIC AGENTS; HUMANS; PNEUMONIA; RISK FACTORS;

EID: 84918507898     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2015.984684     Document Type: Review

References (18)

1. Ilyas S, Moncrieff J. Trends in prescriptions and costs of drugs for mental disorders in England, 1998-2010. Br J Psychiatry 2012;200:393-8
2. Food and Drug Association (FDA). Public health advisory: deaths with antipsychotics in elderly patients with behavioral disturbances. 2005. Available from: www.fda.gov/drugs/drugsafety/postmarketdrugs afetyinformationforpatientsandproviders/ucm053171
3. Information for Healthcare Professionals: conventional Antipsychotics 2008 Food and Drug Association (FDA Available from www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationfor PatientsandProviders/ucm124830.htm
4. Knol W, Van Marum R, Jansen P, et al. Antipsychotic drug use and risk of pneumonia in elderly people J Am Geriatr Soc 2008 56 661-6
5. Trifiro G, Gambassi G, Sen EF, et al. Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study. Ann Intern Med 2010;152:418-25. W139-40
6. Huybrechts KF, Rothman KJ, Silliman RA, et al. Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes. Cmaj 2011;183:E411-19
7. Huybrechts KF, Schneeweiss S, Gerhard T, et al. Comparative safety of antipsychotic medications in nursing home residents. J Am Geriatr Soc 2012;60:420-9
8. Barnett MJ, Perry PJ, Alexander B, et al. Risk of mortality associated with antipsychotic and other neuropsychiatric drugs in pneumonia patients. J Clin Psychopharmacol 2006;26:182-7
9. Gau JT, Acharya U, Khan S, et al. Pharmacotherapy and the risk for community-acquired pneumonia. BMC Geriatr 2010;10:45
10. Aparasu RR, Chatterjee S, Chen H. Risk of pneumonia in elderly nursing home residents using typical versus atypical antipsychotics. Ann Pharmacother 2013;47:464-74
11. Trifiro G, Sultana J, Spina E. Are the safety profiles of antipsychotic drugs used in dementia the same?. An updated review of observational studies. Drug Saf 2014;37:501-20
12. Wang PS, Schneeweiss S, Setoguchi S, et al. Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications. J Clin Psychopharmacol 2007;27:707-10
13. Pratt N, Roughead EE, Ramsay E, et al. Risk of hospitalization for hip fracture and pneumonia associated with antipsychotic prescribing in the elderly: a self-controlled case-series analysis in an Australian health care claims database. Drug Saf 2011;34:567-75
14. Pratt N, Roughead EE, Salter A, et al. Choice of observational study design impacts on measurements of antipsychotic risks in the elderly: a systematic review. BMC Med Res Methodol 2012;12:72
15. Kuo C-J, Yang S-Y, Liao Y-T, et al. Second-generation antipsychotic medications and risk of pneumonia in schizophrenia. Schizophr Bull 2013;39:648-57
16. Yang SY, Liao YT, Chen WJ, et al. Antipsychotic drugs, mood stabilizers, and risk of pneumonia in bipolar disorder: a nationwide case-control study. J Clin Psychiatry 2013;74:e79-86
17. Star K, Bate A, Meyboom RH, et al. Pneumonia following antipsychotic prescriptions in electronic health records: a patient safety concern?. Br J Gen Pract 2010;60:e385-94
18. Hatta K, Kishi Y, Wada K, et al. Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients: a prospective observational study. Int J Geriatr Psychiatry 2014;29:253-62