Interaction of the intermembrane space domain of Tim23 protein with mitochondrial membranes

Journal of Biological Chemistry

Volumn 289, Issue 50, 2014, Pages 34620-34626

  Bajaj, Rakhi ^a   Munari, Francesca ^a,b   Becker, Stefan ^a   Zweckstetter, Markus ^a,b,c  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; MITOCHONDRIA; PHOSPHOLIPIDS; PROTEINS;

INNER MEMBRANES; INTERMEMBRANE SPACE; MITOCHONDRIAL MEMBRANES; MOLECULAR BASIS; OUTER MEMBRANE; OUTER MITOCHONDRIAL MEMBRANES; PROTEIN IMPORT; PROTEIN TRANSLOCATION;

MEMBRANES;

CARDIOLIPIN; LIPOSOME; MITOCHONDRIAL PROTEIN; TIM23 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEIN; TIM23 PROTEIN, S CEREVISIAE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HYDROPHOBICITY; INTERMEMBRANE SPACE DOMAIN; MEMBRANE BINDING; MITOCHONDRIAL MEMBRANE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; AMINO ACID SEQUENCE; ANIMAL; BOVINE; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CARDIOLIPINS; CATTLE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPOSOMES; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL MEMBRANES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84918499431     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.595702     Document Type: Article

References (33)

1. Bauer, M. F., Hofmann, S., Neupert, W., and Brunner, M. (2000) Protein translocation into mitochondria: the role of TIM complexes. Trends Cell Biol. 10, 25-31
2. Chacinska, A., Koehler, C. M., Milenkovic, D., Lithgow, T., and Pfanner, N. (2009) Importing mitochondrial proteins: machineries and mechanisms. Cell 138, 628-644
3. Ryan, K. R., and Jensen, R. E. (1995) Protein translocation across mitochondrial membranes: what a long, strange trip it is. Cell 83, 517-519
4. Schatz, G. (1996) The protein import system of mitochondria. J. Biol. Chem. 271, 31763-31766
5. Neupert, W., and Herrmann, J. M. (2007) Translocation of proteins into mitochondria. Annu. Rev. Biochem. 76, 723-749
6. Glick, B. S., Brandt, A., Cunningham, K., Müller, S., Hallberg, R. L., and Schatz, G. (1992) Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism. Cell 69, 809-822
7. Pfanner, N., and Geissler, A. (2001) Versatility of the mitochondrial protein import machinery. Nat. Rev. Mol. Cell Biol. 2, 339-349
8. van der Laan, M., Hutu, D. P., and Rehling, P. (2010) On the mechanism of preprotein import by the mitochondrial presequence translocase. Biochim. Biophys. Acta 1803, 732-739
9. van der Laan, M., Meinecke, M., Dudek, J., Hutu, D. P., Lind, M., Perschil, I., Guiard, B., Wagner, R., Pfanner, N., and Rehling, P. (2007) Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat. Cell Biol. 9, 1152-1159
10. Chacinska, A., Rehling, P., Guiard, B., Frazier, A. E., Schulze-Specking, A., Pfanner, N., Voos, W., and Meisinger, C. (2003) Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J. 22, 5370-5381
11. Horst, M., Hilfiker-Rothenfluh, S., Oppliger, W., and Schatz, G. (1995) Dynamic interaction of the protein translocation systems in the inner and outer membranes of yeast mitochondria. EMBO J. 14, 2293-2297
12. Schülke, N., Sepuri, N. B., Gordon, D. M., Saxena, S., Dancis, A., and Pain, D. (1999)Amultisubunit complex of outer and inner mitochondrial membrane protein translocases stabilized in vivo by translocation intermediates. J. Biol. Chem. 274, 22847-22854
13. Popov-Celeketić, D., Mapa, K., Neupert, W., and Mokranjac, D. (2008) Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. EMBO J. 27, 1469-1480
14. Tamura, Y., Harada, Y., Shiota, T., Yamano, K., Watanabe, K., Yokota, M., Yamamoto, H., Sesaki, H., and Endo, T. (2009) Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J. Cell Biol. 184, 129-141
15. Donzeau, M., Káldi, K., Adam, A., Paschen, S., Wanner, G., Guiard, B., Bauer, M. F., Neupert, W., and Brunner, M. (2000) Tim23 links the inner and outer mitochondrial membranes. Cell 101, 401-412
16. de la Cruz, L., Bajaj, R., Becker, S., and Zweckstetter, M. (2010) The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences. Protein Sci. 19, 2045-2054
17. Bauer, M. F., Sirrenberg, C., Neupert, W., and Brunner, M. (1996) Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell 87, 33-41
18. Truscott, K. N., Kovermann, P., Geissler, A., Merlin, A., Meijer, M., Driessen, A. J., Rassow, J., Pfanner, N., and Wagner, R. (2001) A presequenceand voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat. Struct. Biol. 8, 1074-1082
19. Vogel, F., Bornhövd, C., Neupert, W., and Reichert, A. S. (2006) Dynamic subcompartmentalization of the mitochondrial inner membrane. J. Cell Biol. 175, 237-247
20. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6, 277-293
21. Schwarzinger, S., Kroon, G. J., Foss, T. R., Chung, J., Wright, P. E., and Dyson, H. J. (2001) Sequence-dependent correction of random coil NMR chemical shifts. J. Am. Chem. Soc. 123, 2970-2978
22. Berjanskii, M. V., and Wishart, D. S. (2005) A simple method to predict protein flexibility using secondary chemical shifts. J. Am. Chem. Soc. 127, 14970-14971
23. Jiang, F., Ryan, M. T., Schlame, M., Zhao, M., Gu, Z., Klingenberg, M., Pfanner, N., and Greenberg, M. L. (2000) Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J. Biol. Chem. 275, 22387-22394
24. Schlame, M., and Ren, M. (2009) The role of cardiolipin in the structural organization of mitochondrial membranes. Biochim. Biophys. Acta 1788, 2080-2083
25. Zhang, M., Mileykovskaya, E., and Dowhan, W. (2002) Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane. J. Biol. Chem. 277, 43553-43556
26. Fernández, C., and Wüthrich, K. (2003) NMR solution structure determination of membrane proteins reconstituted in detergent micelles. FEBS Lett. 555, 144-150
27. Wieprecht, T., Apostolov, O., Beyermann, M., and Seelig, J. (2000) Interaction of a mitochondrial presequence with lipid membranes: role of helix formation for membrane binding and perturbation. Biochemistry 39, 15297-15305
28. Hammen, P. K., Gorenstein, D. G., and Weiner, H. (1996) Amphiphilicity determines binding properties of three mitochondrial presequences to lipid surfaces. Biochemistry 35, 3772-3781
29. Swanson, S. T., and Roise, D. (1992) Binding of a mitochondrial presequence to natural and artificial membranes-role of surface potential. Biochemistry 31, 5746-5751
30. Chacinska, A., Lind, M., Frazier, A. E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H. E., Truscott, K. N., Guiard, B., Pfanner, N., and Rehling, P. (2005) Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-829
31. Ardail, D., Privat, J. P., Egret-Charlier, M., Levrat, C., Lerme, F., and Louisot, P. (1990) Mitochondrial contact sites. Lipid composition and dynamics. J. Biol. Chem. 265, 18797-18802
32. Haines, T. H., and Dencher, N. A. (2002) Cardiolipin: a proton trap for oxidative phosphorylation. FEBS Lett. 528, 35-39
33. Bajaj, R., Jaremko, L., Jaremko, M., Becker, S., and Zweckstetter, M. (2014) Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space. Structure 22, 1501-1511