Recurrent late-onset sepsis in the neonatal intensive care unit: Incidence, clinical characteristics and risk factors

Clinical Microbiology and Infection

Volumn 20, Issue 11, 2014, Pages O928-O935

  Tsai, M H ^a,b,c   Chu, S M ^a,b   Lee, C W ^c   Hsu, J F ^a,b   Huang, H R ^a,b   Chiang, M C ^a,b   Fu, R H ^a,b   Lien, R ^a,b   Huang, Y C ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Antibiotic resistance; Bacteraemia; Late onset sepsis; Recurrence; Risk factor

Indexed keywords

ARTICLE; BIRTH WEIGHT; CASE CONTROL STUDY; CLINICAL FEATURE; COMORBIDITY; CONGENITAL MALFORMATION; FEMALE; GESTATIONAL AGE; HUMAN; INCIDENCE; INFECTION RISK; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEWBORN; NEWBORN INTENSIVE CARE; NEWBORN SEPSIS; PRIORITY JOURNAL; RISK FACTOR; TEACHING HOSPITAL; PATHOLOGY; RECURRENT DISEASE; SEPSIS; SURVIVAL; TAIWAN; TERTIARY CARE CENTER; TREATMENT OUTCOME;

CASE-CONTROL STUDIES; FEMALE; HOSPITALS, TEACHING; HUMANS; INCIDENCE; INFANT, NEWBORN; INTENSIVE CARE, NEONATAL; MALE; RECURRENCE; RISK FACTORS; SEPSIS; SURVIVAL ANALYSIS; TAIWAN; TERTIARY CARE CENTERS; TREATMENT OUTCOME;

EID: 84917679670     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/1469-0691.12661     Document Type: Article

References (30)

1. Boghossian NS, Page GP, Bell EF et al. Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. J Pediatr 2013; 12: 01423.
2. Stoll BJ, Hansen NI, Bell EF et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010; 126: 443-456.
3. Chapman RL, Faix RG. Persistent bacteremia and outcome in late onset infection among infants in a neonatal intensive care unit. Pediatr Infect Dis J 2003; 22: 17-21.
4. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B. Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics 2002; 109: 34-39.
5. Stoll BJ, Hansen N, Fanaroff AA et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110: 285-291.
6. Graham PL 3rd, Begg MD, Larson E, Della-Latta P, Allen A, Saiman L. Risk factors for late onset gram-negative sepsis in low birth weight infants hospitalized in the neonatal intensive care unit. Pediatr Infect Dis J 2006; 25: 113-117.
7. Nambiar S, Singh N. Change in epidemiology of health care-associated infections in a neonatal intensive care unit. Pediatr Infect Dis J 2002; 21: 839-842.
8. Schlapbach LJ, Aebischer M, Adams M et al. Impact of sepsis on neurodevelopmental outcome in a Swiss National Cohort of extremely premature infants. Pediatrics 2011; 128: e348-e357.
9. Stoll BJ, Hansen NI, Adams-Chapman I et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004; 292: 2357-2365.
10. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B, Israel Neonatal Network. Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. Clin Infect Dis 2005; 40: 218-224.
11. Hira V, Sluijter M, Estevão S et al. Clinical and molecular epidemiologic characteristics of coagulase-negative staphylococcal bloodstream infections in intensive care neonates. Pediatr Infect Dis J 2007; 26: 607-612.
12. Cohen-Wolkowiez M, Moran C, Benjamin DK et al. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J 2009; 28: 1052-1056.
13. Jensen US, Knudsen JD, Wehberg S, Gregson DB, Laupland KB. Risk factors for recurrence and death after bacteraemia: a population-based study. Clin Microbiol Infect 2011; 17: 1148-1154.
14. AI-Hasan MN, Eckel-Passow JE, Baddour LM. Recurrent gram-negative bloodstream infection: a 10-year population-based cohort study. J Infect 2010; 61: 28-33.
15. Jensen US, Knudsen JD, Ostergaard C, Gradel KO, Frimodt-Møller N, Schønheyder HC. Recurrent bacteraemia: a 10-year regional population-based study of clinical and microbiological risk factors. J Infect 2010; 60: 191-199.
16. Sanz-Garcia M, Fernández-Cruz A, Rodriguez-Créixems M et al. Recurrent Escherichia coli bloodstream infections: epidemiology and risk factors. Medicine 2009; 88: 77-82.
17. Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG. Seventy-five years of neonatal sepsis at Yale: 1928-2003. Pediatrics 2005; 116: 595-602.
18. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16: 128-140.
19. Sutter D, Stagliano D, Braun L et al. Polymicrobial bloodstream infection in pediatric patients: risk factors, microbiology, and antimicrobial management. Pediatr Infect Dis J 2008; 27: 400-405.
20. Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Matched case-control analysis of polymicrobial bloodstream infection in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2008; 29: 914-920.
21. Taeusch HW, Ballard RA, Gleason CA. Avery's disease of the newborn, 8th edn. Philadelphia, PA: Elsevier Saunders, 2006.
22. Gray JE, Richardson DK, McCormick MC, Workman-Daniels K, Goldmann DA. Neonatal therapeutic intervention scoring system: a therapy-based severity-of-illness index. Pediatrics 1992; 90: 561-567.
23. Perlman SE, Saiman L, Larson EL. Risk factors for late-onset health care-associated bloodstream infections in patients in neonatal intensive care unit. Am J Infect Control 2007; 35: 17-82.
24. Flidel-Rimon O, Friedman S, Lev E, Juster-Reicher A, Amitay M, Shinwell ES. Early enteral feeding and nosocomial sepsis in very low birth weight infants. Arch Dis Child Fetal Neonatal Ed 2004; 89: F289-F292.
25. Samanta S, Farrer K, Breathnach A, Heath PT. Risk factors for late onset gram-negative infections: a case-control study. Arch Dis Child Fetal Neonatal Ed 2011; 96: F15-F18.
26. Yang SP, Chen YY, Hsu HS, Wang FD, Chen LY, Fung CP. A risk factor analysis of healthcare-associated fungal infections in an intensive care unit: a retrospective cohort study. BMC Infect Dis 2013; 13: 10.
27. Kreisel K, Boyd K, Langenberg P, Roghmann MC. Risk factors for recurrence in patients with Staphylococcus aureus infections complicated with bacteremia. Diagn Microbiol Infect Dis 2006; 55: 179-184.
28. Walker TM, Bowler IC, Bejon P. Risk factors for recurrence after Staphylococcus aureus bacteremia. A retrospective matched case-control study. J Infect 2009; 58: 411-416.
29. Linkin DR, Fishman NO, Patel JB, Merrill JD, Lautenbach E. Risk factors for extended-spectrum beta-lactamase-producing Enterobacteriaceae in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2004; 25: 781-783.
30. Le J, Nguyen T, Okamoto M, McKamy S, Lieberman JM. Impact of empiric antibiotic use on the development of infection caused by extended-spectrum beta-lactamase bacteria in a neonatal intensive care unit. Pediatr Infect Dis J 2008; 27: 314-318.