The effect of age on the systemic inflammatory response in patients with community-acquired pneumonia

Clinical Microbiology and Infection

Volumn 20, Issue 11, 2014, Pages 1183-1188

  Van Vught, L A ^a   Endeman, H ^b   Meijvis, S C ^c   Zwinderman, A H ^d   Scicluna, B P ^a   Biesma, D H ^c,e   van der Poll, T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^c ST ANTONIUS HOSPITAL   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Ageing; C reactive protein; Community acquired pneumonia; Cytokines; Systemic inflammatory response

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; CYTOKINE;

ADULT; AGE DISTRIBUTION; AGED; AGING; ARTICLE; BLOOD SAMPLING; COMMUNITY ACQUIRED PNEUMONIA; FEMALE; GERIATRIC PATIENT; HOSPITALIZATION; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PNEUMONIA SEVERITY INDEX; PRIORITY JOURNAL; PROSPECTIVE STUDY; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; VERY ELDERLY; ADOLESCENT; AGE; BLOOD; COMMUNITY ACQUIRED INFECTION; COMPLICATION; MIDDLE AGED; PATHOLOGY; SEVERITY OF ILLNESS INDEX; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; YOUNG ADULT;

STREPTOCOCCUS PNEUMONIAE;

ADOLESCENT; ADULT; AGE FACTORS; AGED, 80 AND OVER; C-REACTIVE PROTEIN; COMMUNITY-ACQUIRED INFECTIONS; CYTOKINES; FEMALE; HUMANS; MALE; MIDDLE AGED; PNEUMONIA, PNEUMOCOCCAL; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; YOUNG ADULT;

EID: 84917671792     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/1469-0691.12717     Document Type: Article

References (30)

1. Pereira JM, Paiva JA, Rello J. Severe sepsis in community-acquired pneumonia-early recognition and treatment. Eur J Intern Med 2012; 23: 412-419.
2. World Health Organisation. The top 10 causes of death. Geneva: World Health Organisation, 2013. Available from http://www.who.int/mediacentre/factsheets/fs310/en/index.html.
3. Kaplan V, Angus DC. Community-acquired pneumonia in the elderly. Crit Care Clin 2003; 19: 729-748.
4. Yende S, Alvarez K, Loehr L et al. Epidemiology and long-term clinical and biologic risk factors for pneumonia in community-dwelling older Americans: analysis of three cohorts. Chest 2013; 144: 1008-1017.
5. Kaplan V, Angus DC, Griffin MF et al. Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med 2002; 165: 766-772.
6. Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med 2006; 34: 15-21.
7. Kaplan V, Clermont G, Griffin MF et al. Pneumonia: still the old man's friend? Arch Intern Med 2003; 163: 317-323.
8. Opal SM, Girard TD, Ely EW. The immunopathogenesis of sepsis in elderly patients. Clin Infect Dis 2005; 41 (Suppl 7): S504-S512.
9. Yende S, Angus DC, Ali IS et al. Influence of comorbid conditions on long-term mortality after pneumonia in older people. J Am Geriatr Soc 2007; 55: 518-525.
10. Hearps AC, Martin GE, Angelovich TA et al. Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell 2012; 11: 867-875.
11. Michaud M, Balardy L, Moulis G et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc 2013; 14: 877-882.
12. Kale SS, Yende S. Effects of aging on inflammation and hemostasis through the continuum of critical illness. Aging Dis 2011; 2: 501-511.
13. Gentile LF, Cuenca AG, Vanzant EL et al. Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Methods 2013; 61: 3-9.
14. Endeman H, Meijvis SC, Rijkers GT et al. Systemic cytokine response in patients with community-acquired pneumonia. Eur Respir J 2011; 37: 1431-1438.
15. Fine MJ, Auble TE, Yealy DM et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997; 336: 243-250.
16. Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol 2013; 13: 875-887.
17. Reber AJ, Chirkova T, Kim JH et al. Immunosenescence and challenges of vaccination against influenza in the aging population. Aging Dis 2012; 3: 68-90.
18. Kale S, Yende S, Kong L et al. The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia. PLoS ONE 2010; 5: e13852.
19. Krone CL, van de Groep K, Trzcinski K, Sanders EA, Bogaert D. Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions. Lancet Respir Med 2014; 2: 141-153.
20. Kelly E, MacRedmond RE, Cullen G et al. Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia? Respirology 2009; 14: 210-216.
21. Pinheiro da Silva F, Zampieri FG, Barbeiro DF et al. Septic shock in older people: a prospective cohort study. Immun Ageing 2013; 10: 21.
22. Della Bella S, Bierti L, Presicce P et al. Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. Clin Immunol 2007; 122: 220-228.
23. Panda A, Qian F, Mohanty S et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010; 184: 2518-2527.
24. Gon Y, Hashimoto S, Hayashi S et al. Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin Exp Immunol 1996; 106: 120-126.
25. Agrawal A, Agrawal S, Cao JN et al. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol 2007; 178: 6912-6922.
26. Butcher SK, Chahal H, Nayak L et al. Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001; 70: 881-886.
27. Kushner I, Rzewnicki D, Samols D. What does minor elevation of C-reactive protein signify? Am J Med 2006; 119: 166 e117-128.
28. Nash SD, Cruickshanks KJ, Klein R et al. Long-term variability of inflammatory markers and associated factors in a population-based cohort. J Am Geriatr Soc 2013; 61: 1269-1276.
29. Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev 2011; 10: 319-329.
30. Wester AL, Blaasaas KG, Wyller TB. Is the concentration of C-reactive protein in bacteraemia associated with age? Immun Ageing 2008; 5: 8.