The ultraviolet A-activated photosensitizer 2-(4-aminophenyl)-7-methoxybenzothiazole suppresses proliferation and induces apoptosis of keloid fibroblasts: A potential adjunctive therapy for keloids

Clinical and Experimental Dermatology

Volumn 40, Issue 1, 2015, Pages 63-70

  Wu, C S ^a   Kuo, H Y ^a   Hu, W P ^a   Wang, J J ^a   Fang, A H ^b   Tien, L Y ^c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINOPHENYL) 7 METHOXYBENZOTHIAZOLE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; ACETYLCYSTEINE; CASPASE 3; PHOTOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 2-(4-AMINOPHENYL)BENZOTHIAZOLE; BENZOTHIAZOLE DERIVATIVE;

ADULT; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; KELOID; MITOCHONDRIAL MEMBRANE POTENTIAL; ULTRAVIOLET A RADIATION; CELL CULTURE; DRUG EFFECTS; PHOTOCHEMOTHERAPY; PROCEDURES; RADIATION RESPONSE;

APOPTOSIS; BENZOTHIAZOLES; CELL PROLIFERATION; CELLS, CULTURED; FIBROBLASTS; HUMANS; KELOID; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 84916931074     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/ced.12448     Document Type: Article

References (22)

1. Craig RD,. Collagen biosynthesis in normal human skin, normal and hypertrophic scar and keloid. Eur J Clin Invest 1975; 5: 69-74.
2. Al-Attar A, Mess S, Thomassen JM, et al,. Keloid pathogenesis and treatment. Plast Reconstr Surg 2006; 117: 286-300.
3. Sayah DN, Soo C, Shaw WW, et al,. Downregulation of apoptosis-related genes in keloid tissues. J Surg Res 1999; 87: 209-16.
4. Ladin DA, Hou Z, Patel D, et al,. p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair Regen 1998; 6: 28-37.
5. Chodon T, Sugihara T, Igawa HH, et al,. Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance. Am J Pathol 2000; 157: 1661-9.
6. Allison RR, Sibata CH,. Oncologic photodynamic therapy photosensitisers: a clinical review. Photodiagnosis Photodyn Ther 2010; 7: 61-75.
7. Dougherty TJ, Gomer CJ, Henderson BW, et al,. Photodynamic therapy. J Natl Cancer Inst 1998; 90: 889-905.
8. Nie Z, Bayat A, Behzad F, et al,. Positive response of a recurrent keloid scar to topical methyl aminolevulinate-photodynamic therapy. Photodermatol Photoimmunol Photomed 2010; 26: 330-2.
9. Ud-Din S, Thomas G, Morris J, et al,. Photodynamic therapy: an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools. Arch Dermatol Res 2012; 305: 205-14.
10. Hu WP, Chen YK, Liao CC, et al,. Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents. Bioorg Med Chem 2010; 18: 6197-207.
11. Fulda S, Debatin KM,. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006; 25: 4798-811.
12. Morton CA, Brown SB, Collins S, et al,. Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. Br J Dermatol 2002; 146: 552-67.
13. Bruls WAG, Slaper H, Van Der Leun JC, Berrens L,. Transmission of human epidermis and stratum corneum as a function of thickness in the ultraviolet and visible wavelengths. Photochem Photobiol 1984; 40: 485-94.
14. Asawanonda P, Khoo LSW, Fitzpatrick TB, Taylor CR,. UV-A1 for Keloid. Arch Dermatol 1999; 135: 388-9.
15. Iinuma S, Farshi SS, Ortel B, et al,. A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin. Br J Cancer 1994; 70: 21-8.
16. Tuan TL, Nichter LS,. The molecular basis of keloid and hypertrophic scar formation. Mol Med Today 1998; 4: 19-24.
17. Kastan MB, Bartek J,. Cell-cycle checkpoints and cancer. Nature 2004; 432: 316-23.
18. Green DR, Reed JC,. Mitochondria and apoptosis. Science 1998; 281: 1309-12.
19. Zamzami N, Marchetti P, Castedo M, et al,. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 1995; 182: 367-77.
20. Porter AG, Jänicke RU,. Emerging roles of caspase-3 in apoptosis. Cell Death Differ 1999; 6: 99-104.
21. Morita A, Sakakibara S, Skakibara N, et al,. Successful treatment of systemic sclerosis with topical PUVA. J Rheumatol 1995; 22: 2361-5.
22. Kanekura T, Fukumaru S, Matsushita S, et al,. Successful treatmet of scleroderma with PUVA therapy. J Dermatol 1996; 23: 455-9.