Rates of formal diagnosis in people screened positive for dementia in primary care: Results of the DelpHi-trial

Journal of Alzheimer's Disease

Volumn 42, Issue 2, 2014, Pages 451-458

  Eichler, Tilly ^a   Thyrian, Jochen René ^a   Hertel, Johannes ^a   Köhler, Leonore ^a   Wucherer, Diana ^a   Dreier, Adina ^b   Michalowsky, Bernhard ^a   Teipel, Stefan ^a,c   Hoffmann, Wolfgang ^a,b  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^c ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

Dementia; differential diagnosis; early diagnosis; primary health care; screening

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DELPHI STUDY; DEMENTIA; DIFFERENTIAL DIAGNOSIS; FEMALE; GENERAL PRACTITIONER; HUMAN; INFORMED CONSENT; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MINI MENTAL STATE EXAMINATION; MULTIINFARCT DEMENTIA; PRIMARY MEDICAL CARE; RANDOMIZED CONTROLLED TRIAL; GERMANY; NEUROPSYCHOLOGICAL TEST; OUTCOME ASSESSMENT; PRIMARY HEALTH CARE; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; QUALITY OF LIFE; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DEMENTIA; DIAGNOSIS, DIFFERENTIAL; FEMALE; GERMANY; HUMANS; LOGISTIC MODELS; MALE; NEUROPSYCHOLOGICAL TESTS; OUTCOME ASSESSMENT (HEALTH CARE); PRIMARY HEALTH CARE; PSYCHIATRIC STATUS RATING SCALES; QUALITY OF LIFE;

EID: 84916925386     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-140354     Document Type: Article

References (43)

1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP (2013) The global prevalence of dementia: A systematic review and metaanalysis. Alzheimers Dement 9, 63-75.
2. Prince M, Bryce R, Ferri C (2011) World Alzheimer Report 2011 - The benefits of early diagnosis and intervention, Alzheimer's Disease International, London.
3. Borson S, Frank L, Bayley PJ, Boustani M, Dean M, Lin PJ, McCarten JR, Morris JC, Salmon DP, Schmitt FA, Stefanacci RG, Mendiondo MS, Peschin S, Hall EJ, Fillit H, Ashford JW (2013) Improving dementia care: The role of screening and detection of cognitive impairment. Alzheimers Dement 9, 151-159.
4. Luck T, Luppa M, Sieber J, Schomerus G, Werner P, Konig HH, Riedel-HellerSG(2012) Attitudes of the German general population toward early diagnosis of dementia-results of a representative telephone survey. PLos ONE 7, e50792.
5. Pinner G, Bouman WP (2003) Attitudes of patients with mild dementia and their carers towards disclosure of the diagnosis. Int Psychogeriatr 15, 279-288.
6. Tinklenberg JR, Kraemer HC,YaffeK, Ross L, Sheikh J, Ashford JW, Yesavage JA, Taylor JL (2007) Donepezil treatment and Alzheimer disease: Can the results of randomized clinical trials be applied to Alzheimer disease patients in clinical practice? Am J Geriatr Psychiatry 15, 953-960.
7. Boustani M, Peterson B, Hanson L, Harris R, LohrKN(2003) Screening for dementia in primary care: A summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 138, 927-937.
8. Birks J, Flicker L (2006) Donepezil for mild cognitive impairment. Cochrane Database Syst Rev 3, Art No.: CD006104.
9. Boustani M, JermoumiR(2012) Forecasting the future impact of early detection and management program for Alzheimer disease. In Dementia Care Research: Scientific Evidence, Current Issues and Future Perspectives, Thyrian J, Hoffmann W, eds. Pabst Science Publishers, Lengerich/Westf., pp. 9-18.
10. Teipel SJ, Ewers M, Reisig V, Schweikert B, Hampel H, Happich M (2007) Long-term cost-effectiveness of donepezil for the treatment of Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci 257, 330-336.
11. Boustani M, Callahan CM, Unverzagt FW, Austrom MG, Perkins AJ, Fultz BA, Hui SL, Hendrie HC (2005) Implementing a screening and diagnosis program for dementia in primary care. J Gen Intern Med 20, 572-577.
12. Connolly A, Gaehl E, Martin H, Morris J, PurandareN(2011) Underdiagnosis of dementia in primary care: Variations in the observed prevalence and comparisons to the expected prevalence. Aging Ment Health 15, 978-984.
13. Mitchell AJ, Meader N, Pentzek M (2011) Clinical recognition of dementia and cognitive impairment in primary care: A meta-analysis of physician accuracy. Acta Psychiatr Scand 124, 165-183.
14. Löppönen M, Raiha I, Isoaho R,Vahlberg T,Kivela SL (2003) Diagnosing cognitive impairment and dementia in primary health care - a more active approach is needed. Age Ageing 32, 606-612.
15. DGPPN and DGN (Deutsche Gesellschaft für Psychiatrie Psychotherapie und Nervenheilkunde and Deutsche Gesellschaft für Neurologie) (2009) S-3 Leitlinie "Demenzen". http://www.dgppn.de/fileadmin/user upload/ medien/ download/pdf/kurzversion-leitlinien/s3-leitlinie-demenz-kf. pdf
16. Vollmar HC, Mand P, Butzlaff M (2008) Demenz. DEGAM - Leitlinie Nr. 12. Omicron Publishing, Düsseldorf.
17. Kaduszkiewicz H,Wiese B, Steinmann S, Schon G, Hoffmann F, van den BH (2013) Diagnosing and diagnosis coding of dementias in claims data from German statutory health insurance. Psychiatr Prax. [Epub] doi: 10.1055/s-0033-1349505
18. Thyrian JR, Fiss T, Dreier A, Böwing G, Angelow A, Lueke S, Teipel S, Flessa S, Grabe HJ, Freyberger HJ, Hoffmann W (2012) Life- and person-centred help in Mecklenburg- Western Pomerania, Germany (DelpHi): Study protocol for a randomised controlled trial. Trial 13, 56.
19. Calabrese P, Kessler J (2000) Screening for cognitive impairment in dementia - the DemTect procedure. Eur Neuropsychopharmacol 10(Suppl 3), 369.
20. Thyrian JR, Hoffmann W (2012) Dementia care and general physicians-a survey on prevalence, means, attitudes and recommendations. Cent Eur J Public Health 20, 270-275.
21. Eichler T, Thyrian JR, Dreier A, Wucherer D, Köhler L, Fiss T, Böwing G, Michalowsky B, HoffmannW(2014) Dementia care management: Going newways in ambulant dementia care within a GP-based randomized controlled intervention trial. Int Psychogeriatr 26, 247-256.
22. Kessler J, Markowitsch HJ, Denzler P (1990) Mini-Mental- Status-Test (MMST) [German Version].
23. Gauggel S, Birkner B (1999) Validity and reliability of a German version of the Geriatric Depression Scale (GDS). Zeitschrift fur Klinische Psychologie-Forschung und Praxis 28, 18-27.
24. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, AdeyM, Leirer VO (1982) Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 17, 37-49.
25. Erzigkeit H, Lehfeld H, Pena-Casanova J, Bieber F,Yekrangi- Hartmann C, Rupp M, Rappard F, Arnold K, Hindmarch I (2001) The Bayer-Activities of Daily Living Scale (B-ADL): Results from a validation study in three European countries. Dement Geriatr Cogn Disord 12, 348-358.
26. Hindmarch I, Lehfeld H, de JP, Erzigkeit H (1998) The Bayer Activities of Daily Living Scale (B-ADL). Dement Geriatr Cogn Disord 9(Suppl 2), 20-26.
27. Breslow N, Day N (1980) Statistical Methods in Cancer Research, Vol 1. The analysis of case-control studies. (IARC Scientific Publication no. 32), International Agency for Research on Cancer, Lyon.
28. Hosmer D, LemeshowS, SturdivantR(2013) Applied Logistic Regression, John Wiley & Sons, New Jersey.
29. Royston P, SauerbreiW(2008) Multivariable Model-Building - A pragmatic approach to regression analysis based on fractional polynomials for continuous variables, John Wiley & Sons, New York.
30. Rust KF, Rao JN (1996) Variance estimation for complex surveys using replication techniques. Stat Methods Med Res 5, 283-310.
31. Stata Corp (2009) Stata Statistical Software: Release 11.
32. Huber M, Kolzsch M, Rapp MA, Wulff I, Kalinowski S, Bolbrinker J, Hofmann W, Scholze J, Drager D, Kreutz R (2012) Antipsychotic drugs predominate in pharmacotherapy of nursing home residents with dementia. Pharmacopsychiatry 45, 182-188.
33. Majic T, Pluta JP, Mell T, Aichberger MC, Treusch Y, Gutzmann H, Heinz A, Rapp MA (2010) The pharmacotherapy of neuropsychiatric symptoms of dementia: A cross-sectional study in 18 homes for the elderly in Berlin. Dtsch Arztebl Int 107, 320-327.
34. Riedel-Heller SG, Schork A, Matschinger H, Angermeyer MC (1999) The role of referrals in diagnosing dementia at the primary care level. Int Psychogeriatr 11, 251-262.
35. Qiu C, De RD, Fratiglioni L (2007) The epidemiology of the dementias: An update. Curr Opin Psychiatry 20, 380-385.
36. Riedel-Heller SG, Schork A, Fromm N, Angermeyer MC (2000) [Dementia patients in general practice-results of a survey]. Z Gerontol Geriatr 33, 300-306.
37. Borson S, Scanlan J, Hummel J, Gibbs K, Lessig M, Zuhr E (2007) Implementing routine cognitive screening of older adults in primary care: Process and impact on physician behavior. J Gen Intern Med 22, 811-817.
38. Riedel-Heller SG, Busse A, Aurich C, Matschinger H, Angermeyer MC (2001) Prevalence of dementia according to DSM-III-R and ICD-10: Results of the Leipzig Longitudinal Study of the Aged (LEILA75+) Part 1. Br J Psychiatry 179, 250-254.
39. Kalbe E, Kessler J, Calabrese P, Smith R, Passmore AP, Brand M, Bullock R (2004) DemTect: A new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int J Geriatr Psychiatry 19, 136-143.
40. Kohn N, Kalbe E, GeorgH,Kessler J (2007)VergleichMMST und DemTect: Spezifität und Sensitivität bei primär kognitiven Störungen. Akt Neurol. 34, P672.
41. Mackin RS, Ayalon L, Feliciano L, Arean PA (2010) The sensitivity and specificity of cognitive screening instruments to detect cognitive impairment in older adults with severe psychiatric illness. J Geriatr Psychiatry Neurol 23, 94-99.
42. Le Couteur DG, Doust J, Creasey H, Brayne C (2013) Political drive to screen for pre-dementia: Not evidence based and ignores the harms of diagnosis. BMJ 347, f5125.
43. Brunet MD, McCartney M, Heath I, Tomlinson J, Gordon P, Cosgrove J, Deveson P, Gordon S, Marciano SA, Colvin D, Sayer M, Silverman R, Bhattia N (2012) There is no evidence base for proposed dementia screening. BMJ 345, e8588.