Radiation-induced matrix metalloproteinases limit natural killer cell-mediated anticancer immunityin NCI-H23 lung cancer cells

Molecular Medicine Reports

Volumn 11, Issue 3, 2015, Pages 1800-1806

  Heo, Woong ^a   Lee, Young Shin ^a   Son, Cheol Hun ^a,b   Yang, Kwangmo ^b   Park, You Soo ^b   Bae, Jaeho ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Dongnam Institute of Radiological and Medical Sciences   (South Korea)

Author keywords

Ionizing radiation; Matrix metalloproteases; Natural killer group 2 member D ligands

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE INHIBITOR; NATURAL KILLER CELL RECEPTOR NKG2D; ADAM10 PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; MESSENGER RNA; MHC CLASS I-RELATED CHAIN A; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; SECRETASE;

ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL DEATH; CYTOTOXICITY ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IONIZING RADIATION; LUNG CANCER CELL LINE; NATURAL KILLER CELL; NON SMALL CELL LUNG CANCER; PROTEIN EXPRESSION; TUMOR IMMUNITY; CELL MEMBRANE; CYTOTOXICITY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG TUMOR; METABOLISM; RADIATION RESPONSE; TUMOR CELL LINE;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE, TUMOR; CELL MEMBRANE; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE INHIBITORS; MATRIX METALLOPROTEINASES; MEMBRANE PROTEINS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; RADIATION, IONIZING; RNA, MESSENGER;

EID: 84916625702     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2918     Document Type: Article

References (23)

1. Friedman EJ: Immune modulation by ionizing radiation and its implications for cancer immunotherapy. Curr Pharm Des 8: 1765-1780, 2002.
2. Nakagawa K, Yoshida F, Omori N, Tsunoda T and Nose T: The effect of radiation therapy combined with natural killer cells against spontaneous murine fibrosarcoma. Biotherapy 2: 69-75, 1990.
3. Kim JY, Son YO, Park SW, et al: Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation. Exp Mol Med 38: 474-484, 2006.
4. von Essen CF: Radiation enhancement of metastasis: a review. Clin Exp Metastasis 9: 77-104, 1991.
5. Wang CJ, Chen HC, Huang EY and Lee SP: Elective neck irradiation for nasopharyngeal carcinoma. Chang Gung Med J 23: 387-395, 2000.
6. Davidson B, Goldberg I, Kopolovic J, et al: MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma ? a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization. Gynecol Oncol 73: 372-382, 1999.
7. Ekinci T, Ozbay PO, Yig-it S, Yavuzcan A, Uysal S and Soylu F: The correlation between immunohistochemical expression of MMP-2 and the prognosis of epithelial ovarian cancer. Ginekol Pol 85: 121-130, 2014.
8. Liu WW, Zeng ZY, Wu QL, Hou JH and Chen YY: Overexpression of MMP-2 in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. Otolaryngol Head Neck Surg 132: 395-400, 2005.
9. Boutet P, Agüera-González S, Atkinson S, et al: Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. J Immunol 182: 49-53, 2009.
10. Kohga K, Takehara T, Tatsumi T, et al: Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. Cancer Res 69: 8050-8057, 2009.
11. Lee BK, Kim MJ, Jang HS, et al: A high concentration of MMP-2/gelatinase A and MMP-9/gelatinase B reduce NK cell-mediated cytotoxicity against an oral squamous cell carcinoma cell line. In Vivo 22: 593-597, 2008.
12. Liu G, Atteridge CL, Wang X, Lundgren AD and Wu JD: The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases. J Immunol 184: 3346-3350, 2010.
13. Sun D, Wang X, Zhang H, Deng L and Zhang Y: MMP9 mediates MICA shedding in human osteosarcomas. Cell Biol Int 35: 569-574, 2011.
14. Park SW, Bae JH, Kim SD, et al: Comparison of level of NKG2D ligands between normal and tumor tissue using multiplex RT-PCR. Cancer Invest 25: 299-307, 2007.
15. Eissmann P, Evans JH, Mehrabi M, Rose EL, Nedvetzki S and Davis DM: Multiple mechanisms downstream of TLR-4 stimulation allow expression of NKG2D ligands to facilitate macrophage/NK cell crosstalk. J Immunol 184: 6901-6909, 2010.
16. Gasser S, Orsulic S, Brown EJ and Raulet DH: The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436: 1186-1190, 2005.
17. Lanier LL: NK cell recognition. Annu Rev Immunol 23: 225-274, 2005.
18. Ljunggren HG and Malmberg KJ: Prospects for the use of NK cells in immunotherapy of human cancer. Nat Rev Immunol 7: 329-339, 2007.
19. Bae JH, Kim JY, Kim MJ, et al: Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70. J Immunother 33: 391-401, 2010.
20. Son CH, Keum JH, Yang K, et al: Synergistic enhancement of NK cell-mediated cytotoxicity by combination of histone deacetylase inhibitor and ionizing radiation. Radiat Oncol 9: 49, 2014.
21. Kim JY, Bae JH, Lee SH, et al: Induction of NKG2D ligands and subsequent enhancement of NK cell-mediated lysis of cancer cells by arsenic trioxide. J Immunother 31: 475-486, 2008.
22. Chitadze G, Bhat J, Lettau M, Janssen O and Kabelitz D: Generation of soluble NKG2D ligands: proteolytic cleavage, exosome secretion and functional implications. Scand J Immunol 78: 120-129, 2013.
23. Groh V, Wu J, Yee C and Spies T: Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419: 734-738, 2002.