Czech mass methanol outbreak 2012: Epidemiology, challenges and clinical features

Clinical Toxicology

Volumn 52, Issue 10, 2014, Pages 1013-1024

  Zakharov, Sergey ^a   Pelclova, Daniela ^a   Urban, Pavel ^a   Navratil, Tomas ^a,b   Diblik, Pavel ^c   Kuthan, Pavel ^c   Hubacek, Jaroslav A ^d   Miovsky, Michal ^a   Klempir, Jiri ^a   Vaneckova, Manuela ^a   Seidl, Zdenek ^a   Pilin, Alexander ^a   Fenclova, Zdenka ^a   Petrik, Vit ^a   Kotikova, Katerina ^a   Nurieva, Olga ^a   Ridzon, Petr ^a   Rulisek, Jan ^c   Komarc, Martin ^a   Hovda, Knut Erik ^e  

^a CHARLES UNIVERSITY   (Czech Republic)

^b J HEYROVSKÝ INSTITUTE OF PHYSICAL CHEMISTRY   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Epidemiology; Methanol poisoning; Outcomes; Prognosis; Symptoms; Treatment

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; BICARBONATE; FOLIC ACID; METHANOL; ANTIDOTE; BIOLOGICAL MARKER; PYRAZOLE DERIVATIVE;

ADOLESCENT; ADULT; AGED; ALCOHOL BLOOD LEVEL; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL FEATURE; CLINICAL PROTOCOL; COMA; CONTINUOUS HEMODIALYSIS; CONTROLLED STUDY; CZECH REPUBLIC; DISEASE SEVERITY; DRUG EFFICACY; EPIDEMIC; EPIDEMIOLOGICAL DATA; FEMALE; HEMODIALYSIS; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC ACIDOSIS; METHANOL POISONING; MORTALITY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; PROBABILITY; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; SURVIVOR; VISUAL DISORDER; VISUAL FIELD; ACIDOSIS; BLOOD; CHEMICALLY INDUCED; CONSCIOUSNESS; DRUG OVERDOSE; MASS DISASTER; MIDDLE AGED; RENAL REPLACEMENT THERAPY; RISK; RISK FACTOR; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; TIME; TREATMENT OUTCOME; VISION DISORDERS; YOUNG ADULT;

ACIDOSIS; ADOLESCENT; ADULT; AGED; ANTIDOTES; BIOLOGICAL MARKERS; CONSCIOUSNESS; CZECH REPUBLIC; DISEASE OUTBREAKS; DRUG OVERDOSE; ETHANOL; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; LOGISTIC MODELS; MALE; MASS CASUALTY INCIDENTS; METHANOL; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PROSPECTIVE STUDIES; PYRAZOLES; RENAL DIALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME; VISION DISORDERS; YOUNG ADULT;

EID: 84916227323     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2014.974106     Document Type: Article

References (29)

1. Hovda KE, Hunderi OH, Tafjord AB, Dunlop O, Rudberg N, Jacobsen D. Methanol outbreak in Norway 2002-2004: epidemiology, clinical features and prognostic signs. J Intern Med 2005; 258:181-190.
2. Paasma R, Hovda KE, Tikkerberi A, Jacobsen D. Methanol mass poisoning in Estonia: outbreak in 154 patients. Clin Toxicol 2007; 45:152-157.
3. Bennett IL Jr, Cary FH, Mitchell GL Jr, Cooper MN. Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases. Medicine (Baltimore) 1953; 32:431-463.
4. Sejersted OM, Ostborg J, Jansen H. Methanol poisoning. Emergency measures, diagnostic and therapeutic problems during the Kristian-sand outbreak in 1979. Tidsskr Nor Laegeforen 1981; 101:699-706. Metanolforgftning. Beredskapsmessige, diagnostiske og terapeutiske problemer ved masseulykken i Kristiansand 1979.
5. Hovda KE, Hunderi OH, Rudberg N, Froyshov S, Jacobsen D. Anion and osmolal gaps in the diagnosis of methanol poisoning: clinical study in 28 patients. Intensive Care Med 2004; 30:1842-1846.
6. Megarbane B, Borron SW, Baud FJ. Current recommendations for treatment of severe toxic alcohol poisonings. Intensive Care Med 2005; 31:189-195.
7. Barceloux DG, Bond GR, KrenzelokEP, Cooper H, Vale JA. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol 2002; 40:415-446.
8. Libiger M, Sterba R. Metanolová smes mela jít do ostfikovacu, odmítli vinu hlavní obžalovaní. IDnes [Internet]. 2014 15. 4. 2014. Available from: http://zlin.idnes.cz/hlavni-obzalovani-v-metanolove-kauze-u-zlinskeho-soudu-pje-/zlin-zpravy.aspx?c = A140305-121845-zlin-zpravy-ras.
9. WHO. 18th Model List of Essential Medicines2013; 2014 (20.2.2014). Available from: http://www.who.int/medicines/publications/essential medicines/18th-EML-Final-web-8Jul13.pdf?ua = 1
10. Vaneckova M, Zakharov S, Klempir J, Ruzicka E, Bezdicek O, Liskova I, et al. Methanol intoxication on magnetic resonance imaging. Cesk Slov Neurol N 2014; 77:235-239.
11. Hovda KE, Jacobsen D. Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning. Hum Exp Toxicol 2008; 27:539-546.
12. Hovda KE, Urdal P, Jacobsen D. Increased serum formate in the diagnosis of methanol poisoning. J Anal Toxicol 2005; 29:586-588.
13. Schaller KH, Triebig GT. Formate determination with formate dehydrogenase. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis. Weinheim: Verlag Chemie; 1984:668-672.
14. Blomme B, Lheureux P, Gerlo E, Maes V. Cobas Mira S endpoint enzymatic assay for plasma formate. J Anal Toxicol 2001; 25:77-80.
15. Aabakken L, Johansen KS, Rydningen EB, Bredesen JE, Ovrebo S, Jacobsen D. Osmolal and anion gaps in patients admitted to an emergency medical department. Hum Exp Toxicol 1994; 13:131-134.
16. Zakharov S, Nurieva O, Navratil T, Diblik P, Kuthan P, Pelclova D. Acute methanol poisonings: Folates administration and visual sequelae. J Appl Biomed 2014; DOI: 10.1016/j.jab.2014.04.001.
17. Hassanian-Moghaddam H, Nikfarjam A, Mirafzal A, Saberinia A, Nasehi AA, Masoumi AH, Memaryan N. Methanol mass poisoning in Iran: role of case f nding in outbreak management. J Public Health 2014; doi: 10.1093/pubmed/fdu038.
18. Liu JJ, Daya MR, Carrasquillo O, Kales SN. Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol 1998; 36:175-181.
19. Hubacek JA, Pelclova D, Seidl Z, Vaneckova M, Klempir J, Ruzicka E, et al. Rare alleles within the CYP2E1 (MEOS system) could be associated with better short-term health outcome after acute methanol poisoning. Basic Clin Pharmacol Toxicol 2014; Doi: 10.1111/bcpt.12310.
20. Naraqi S, Dethlefs RF, Slobodniuk RA, Sairere JS. An outbreak of acute methyl alcohol intoxication. Aust N Z J Med 1979; 9:65-68.
21. Lushine KA, Harris CR, Holger JS. Methanol ingestion: prevention of toxic sequelae after massive ingestion. J Emerg Med 2003; 24: 433-436.
22. Brent J, McMartin K, Phillips S, Aaron C, Kulig K. Fomepizole for the treatment of methanol poisoning. N Engl J Med 2001; 344:424-429.
23. Zakharov S, Kurcova I, Navratil T, Salek T, Komarc M, Pelclova D. Is the measurement of serum formate concentration useful in the diagnostics of acute methanol poisoning? A prospective study of 38 patients. Basic Clin Pharmacol Toxicol; DOI: 10.1111/bcpt.12338.
24. Paasma R, Hovda KE, Hassanian-Moghaddam H, Brahmi N, Afshari R, Sandvik L, Jacobsen D. Risk factors related to poor outcome after methanol poisoning and the relation between outcome and antidotes-a multicenter study. Clin Toxicol 2012; 50:823-831.
25. Smith SR, Smith SJ, Buckley BM. Combined formate and lactate acidosis in methanol poisoning. Lancet 1981; 2:1295-1296.
26. Jacobsen D, Hovda KE. Methanol. In: Shannon MW, Borron SW, Burns MJ, eds. Haddad And Winchester's Clinical Management of Poisoning And Drug Overdose. Philadelphia, USA: WB Saunders; 2007:605-611.
27. Sanaei-Zadeh H, Esfeh SK, Zamani N, Jamshidi F, Shadnia S. Hyperglycemia is a strong prognostic factor of lethality in methanol poisoning. J Med Toxicol 2011; 7:189-194.
28. Hantson P, Haufroid V, Wallemacq P. Formate kinetics in methanol poisoning. Hum Exp Toxicol 2005; 24:55-59.
29. Zakharov S, Pelclova D, Navratil T, Belacek J, Kurcova I, Komzak O, et al. Methanol and formate elimination half-life during treatment for methanol poisoning: intermittent haemodialysis vs. continuous haemodialysis/haemodiafltration. Kidney Int 2014; 86:199-207.