Mitofusin 2 ameliorates aortic remodeling by suppressing ras/raf/ERK pathway and regulating mitochondrial function in vascular smooth muscle cells

International Journal of Cardiology

Volumn 178, Issue , 2015, Pages 165-167

  Wang, Zuoguang ^a   Niu, Qiuli ^a   Peng, Xiaoyun ^b   Li, Mei ^a   Liu, Ya ^a   Liu, Jielin ^a   Wen, Shaojun ^a   Wei, Yongxiang ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b NORTHWEST INSTITUTE OF PLATEAU BIOLOGY   (China)

Author keywords

Antihypertensive treatment; Aortic remodeling; Mitochondria; Mitofusin 2; Oxidative stress

Indexed keywords

AMLODIPINE BESYLATE; CANDESARTAN HEXETIL; CARVEDILOL; DIHYDRALAZINE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MITOFUSIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PERINDOPRIL; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; MITOFUSIN 2 PROTEIN, RAT; RAF KINASES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; AORTIC REMODELING; ARTERIAL WALL THICKNESS; BLOOD VESSEL FUNCTION; CELL DENSITY; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; GENE EXPRESSION; HYPERTENSION; LETTER; MFN2 GENE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; ONCOGENE RAS; PROTEIN EXPRESSION; RAF GENE; RAT; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE; ANIMALS; AORTA; BIOSYNTHESIS; GENES, RAS; MAP KINASE SIGNALING SYSTEM; METABOLISM; MITOCHONDRIA; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHYSIOLOGY; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VASCULAR REMODELING;

ANIMALS; AORTA; GENES, RAS; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RAF KINASES; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VASCULAR REMODELING;

EID: 84916196503     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.10.122     Document Type: Article

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