GATA-4 protects against hypoxia-induced cardiomyocyte injury: effects on mitochondrial membrane potential

Canadian Journal of Physiology and Pharmacology

Volumn 92, Issue 8, 2014, Pages 669-678

  Li, Hong Xia ^a   Zhou, Ya Feng ^a   Zhao, Xin ^a   Jiang, Bin ^a   Yang, Xiang Jun ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Apoptosis; Cardioprotection; Conditioned media; GATA 4; Hypoxia; Mesenchymal stem cell; Mitochondrial membrane potential; Paracrine factors

Indexed keywords

CULTURE MEDIUM; SOMATOMEDIN C; TRANSCRIPTION FACTOR GATA 4; VASCULOTROPIN;

ANIMAL; APOPTOSIS; CELL CULTURE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL SURVIVAL; COCULTURE; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; FEMUR; GENETIC TRANSDUCTION; GENETICS; HEART MUSCLE CELL; MALE; MESENCHYMAL STROMA CELL; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NEWBORN; SPRAGUE DAWLEY RAT; TIBIA;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELL DIFFERENTIATION; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; FEMUR; GATA4 TRANSCRIPTION FACTOR; INSULIN-LIKE GROWTH FACTOR I; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENCHYMAL STROMAL CELLS; MYOCYTES, CARDIAC; RATS, SPRAGUE-DAWLEY; TIBIA; TRANSDUCTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 84905037528     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2014-0009     Document Type: Article

References (25)

1. Aries, A., Paradis, P., Lefebvre, C., Schwartz, R.J., and Nemer, M. 2004. Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc. Natl. Acad. Sci. U.S.A. 101(18): 6975-6980. doi:10.1073/pnas.0401833101. PMID: 15100413.
2. Assmus, B., Rolf, A., Erbs, S., Elsasser, A., Haberbosch, W., Hambrecht, R., et al. 2010. Clinical outcome 2 years after intracoronary administration of bone marrow-derived progenitor cells in acute myocardial infarction. Circ. Heart Fail. 3(1): 89-96. doi:10.1161/CIRCHEARTFAILURE.108.843243. PMID:19996415.
3. Cannon, R.O., III. 2005. Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction. Nat. Clin. Pract. Cardiovasc. Med. 2(2): 88-94. doi:10.1038/ncpcardio0096. PMID:16265379.
4. Gnecchi, M., He, H., Noiseux, N., Liang, O.D., Zhang, L., Morello, F., et al. 2006. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. 20(6): 661-669. doi:10.1096/fj.05-5211com. PMID:16581974.
5. Gnecchi, M., Zhang, Z., Ni, A., and Dzau, V.J. 2008. Paracrine mechanisms in adult stem cell signaling and therapy. Circ. Res. 103(11): 1204-1219. doi:10.1161/CIRCRESAHA.108.176826. PMID:19028920.
6. Grepin, C., Nemer, G., and Nemer, M. 1997. Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development, 124(12): 2387-2395. PMID:9199365.
7. Hayakawa, Y., Chandra, M., Miao, W., Shirani, J., Brown, J.H., Dorn, G.W., II, et al. 2003. Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation, 108(24): 3036-3041. doi:10.1161/01.CIR.0000101920.72665.58. PMID:14638549.
8. ILAR (Institute of Laboratory Animal Resources). 1996. Guide for the Care and Use of Laboratory Animals. NIH Publication No. 85-23 (revised 1996). National Academy Press, Washington, D.C. Available from http://www.nap.edu/openbook.php?record_id=5140.
9. Kim, Y., Ma, A.G., Kitta, K., Fitch, S.N., Ikeda, T., Ihara, Y., et al. 2003. Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis. Mol. Pharmacol. 63(2): 368-377. doi:10.1124/mol.63.2.368. PMID:12527808.
10. Li, H., Zuo, S., He, Z., Yang, Y., Pasha, Z., Wang, Y., et al. 2010. Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival. Am. J. Physiol. Heart Circ. Physiol. 299(6): H1772-H1781. doi:10.1152/ajpheart.00557.2010. PMID:20870802.
11. Li, H., Zuo, S., Pasha, Z., Yu, B., He, Z., Wang, Y., et al. 2011. GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via upregulating IGFBP-4. Cytotherapy, 13(9): 1057-1065. doi:10.3109/14653249.2011.597380. PMID:21846294.
12. Li, L., Takemura, G., Li, Y., Miyata, S., Esaki, M., Okada, H., et al. 2006. Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy. Circulation, 113(4): 535-543. doi:10.1161/CIRCULATIONAHA.105.568402. PMID:16449733.
13. Li, W., Ma, N., Ong, L.L., Nesselmann, C., Klopsch, C., Ladilov, Y., et al. 2007. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells, 25(8): 2118-2127. doi:10.1634/stemcells.2006-0771. PMID:17478584.
14. Lin, H., Shabbir, A., Molnar, M., Yang, J., Marion, S., Canty, J.M., Jr., et al. 2008. Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells. J. Cell. Physiol. 216(2): 458-468. doi:10.1002/jcp.21414. PMID:18288639.
15. Makkar, R.R., Price, M.J., Lill, M., Frantzen, M., Takizawa, K., Kleisli, T., et al. 2005. Intramyocardial injection of allogenic bone marrow-derived mesenchymal stem cells without immunosuppression preserves cardiac function in a porcine model of myocardial infarction. J. Cardiovasc. Pharmacol. Ther. 10(4): 225-233. doi:10.1177/107424840501000403. PMID:16382259.
16. Medicetty, S., Wiktor, D., Lehman, N., Raber, A., Popovic, Z.B., Deans, R., et al. 2012. Percutaneous adventitial delivery of allogeneic bone marrow-derived stem cells via infarct-related artery improves long-term ventricular function in acute myocardial infarction. Cell Transplant. 21(6): 1109-1120. doi:10.3727/096368911X603657. PMID:22004910.
17. Mirotsou, M., Zhang, Z., Deb, A., Zhang, L., Gnecchi, M., Noiseux, N., et al. 2007. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc. Natl. Acad. Sci. U.S.A. 104(5): 1643-1648. doi:10.1073/pnas.0610024104. PMID: 17251350.
18. Nagaya, N., Kangawa, K., Itoh, T., Iwase, T., Murakami, S., Miyahara, Y., et al. 2005. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation, 112(8): 1128-1135. doi: 10.1161/CIRCULATIONAHA.104.500447. PMID:16103243.
19. Oka, T., Xu, J., and Molkentin, J.D. 2007. Re-employment of developmental transcription factors in adult heart disease. Semin. Cell Dev. Biol. 18(1): 117-131. doi:10.1016/j.semcdb.2006.11.012. PMID:17161634.
20. Patient, R.K., and McGhee, J.D. 2002. The GATA family (vertebrates and invertebrates). Curr. Opin. Genet. Dev. 12(4): 416-422. doi:10.1016/S0959-437X(02)00319-2. PMID:12100886.
21. Rysa, J., Tenhunen, O., Serpi, R., Soini, Y., Nemer, M., Leskinen, H., et al. 2010. GATA-4 is an angiogenic survival factor of the infarcted heart. Circ. Heart Fail. 3(3): 440-450. doi:10.1161/CIRCHEARTFAILURE.109.889642. PMID:20200331.
22. Shan, X., Xu, X., Cao, B., Wang, Y., Guo, L., Zhu, Q., et al. 2009. Transcription factor GATA-4 is involved in erythropoietin-induced cardioprotection against myocardial ischemia/reperfusion injury. Int. J. Cardiol. 134(3): 384-392. doi: 10.1016/j.ijcard.2008.03.043. PMID:18672303.
23. Uemura, R., Xu, M., Ahmad, N., and Ashraf, M. 2006. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ. Res. 98(11): 1414-1421. doi:10.1161/01.RES.0000225952.61196.39. PMID:16690882.
24. Xu, M., Millard, R.W., and Ashraf, M. 2012. Role of GATA-4 in differentiation and survival of bone marrow mesenchymal stem cells. Prog. Mol. Biol. Transl. Sci. 111: 217-241. doi:10.1016/B978-0-12-398459-3.00010-1. PMID:22917233.
25. Yu, B., Gong, M., Wang, Y., Millard, R.W., Pasha, Z., Yang, Y., et al. 2013. Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles. PLoS One, 8(8): e73304. doi:10.1371/journal.pone.0073304. PMID:24015301.