A novel assay to diagnose hereditary angioedema utilizing inhibition of bradykinin-forming enzymes

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 70, Issue 1, 2015, Pages 115-119

  Joseph, K ^a   Bains, S ^a   Tholanikunnel, B G ^a   Bygum, A ^b   Aabom, A ^b   Koch, C ^b   Farkas, H ^c   Varga, L ^c   Ghebrehiwet, B ^d   Kaplan, A P ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

bradykinin; factor XIIa; hereditary angioedema; hereditary angioedema diagnosis; kallikrein

Indexed keywords

BLOOD CLOTTING FACTOR 12A; COMPLEMENT COMPONENT C1S INHIBITOR; PLASMA KALLIKREIN; BRADYKININ;

ANGIONEUROTIC EDEMA; ARTICLE; BIOTINYLATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MAJOR CLINICAL STUDY; PLASMA; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; ANGIOEDEMAS, HEREDITARY; BIOSYNTHESIS; CASE CONTROL STUDY; DIAGNOSTIC USE; ENZYMOLOGY; METABOLISM; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ANGIOEDEMAS, HEREDITARY; BRADYKININ; CASE-CONTROL STUDIES; COMPLEMENT C1 INHIBITOR PROTEIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR XIIA; HUMANS; PLASMA KALLIKREIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84915820025     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12520     Document Type: Article

References (15)

1. Frank MM, Gelfand JA, Atkinson JP,. Hereditary angioedema: the clinical syndrome and its management. Ann Intern Med 1976; 84: 580-593.
2. Zuraw B,. Clinical practice. Hereditary angioedema. N Engl J Med 2008; 359: 1027-1036.
3. Agostoni A, Cicardi M,. Hereditary and acquired C1-inhibitor deficiency: biological and clinical characteristics in 235 patients. Medicine (Baltimore) 1992; 71: 206-215.
4. Bork K, Siedlecki K, Bosch S, Schopf RE, Kreuz W,. Asphyxiation by laryngeal edema in patients with hereditary angioedema. Mayo Clin Proc 2000; 75: 349-354.
5. Bork K, Hardt J, Witzke G,. Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency. J Allergy Clin Immunol 2012; 130: 692-697.
6. Wagenaar-Bos IGA, Drouet C, Aygoren-Pursun E, Bork K, Bucher C, Bygum A, et al. Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations. J Immunol Methods 2008; 338: 14-20.
7. Kaplan AP, Joseph K,. The bradykinin-forming cascade and its role in hereditary angioedema. Ann Allergy Asthma Immunol 2010; 104: 193-204.
8. Gigli I, Mason JW, Colman RW, Austen KF,. Interaction of plasma kallikrein with the C1 inhibitor. J Immunol 1970; 104: 574-581.
9. Kaplan AP, Joseph K,. Kinin formation in C1 inhibitor deficiency. J Allergy Clin Immunol 2010; 125: 1411-1412.
10. Zahedi R, Bissler JJ, Davis AE III, Andreadis C, Wisnieski JJ,. Unique C1 inhibitor dysfunction in a kindred without angioedema: II. Identification of an Ala443-Val substitution and functional analysis of the recombinant mutant protein. J Clin Invest 1995; 95: 1299-1305.
11. Wisnieski JJ, Knauss TC, Yike I, Dearborn DG, Narvy RL, Naff GB,. Unique C1 inhibitor dysfunction in a kindred without angioedema. I. A mutant c1 inhibitor that inhibits C1s but not C1r. J Immunol 1994; 152: 3199-3209.
12. Bradford MM,. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
13. Harpel PC, Lewin MF, Kaplan AP,. Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes. J Biol Chem 1985; 260: 4257-4263.
14. Tarzi MD, Hickey A, Forster T, Mohammadi M, Longhurst HJ,. An evaluation of tests used for the diagnosis and monitoring of C1 inhibitor deficiency: normal serum C4 does not exclude hereditary angio-oedema. Clin Exp Immunol 2007; 149: 513-516.
15. Austen KF, Sheffer AL,. Detection of hereditary angioneurotic edema by demonstration of a reduction in the second component of complement. N Eng J Med 1965; 272: 649-656.