Chitosan nanoparticles for siRNA Delivery: Optimization of processing/formulation parameters

Nucleic Acid Therapeutics

Volumn 24, Issue 6, 2014, Pages 420-427

  Esmaeilzadeh Gharehdaghi, Elina ^a,b   Amani, Amir ^a,b   Khoshayand, Mohammad Reza ^c   Banan, Mehdi ^d   Esmaeilzadeh Gharehdaghi, Elika ^d   Amini, Mohammad Ali ^e   Faramarzi, Mohammad Ali ^a,f  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d UNIVERSITY OF SOCIAL WELFARE AND REHABILITATION SCIENCES   (Iran)

^e ISLAMIC AZAD UNIVERSITY   (Iran)

^f TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

CHITOSAN; NANOPARTICLE; SMALL INTERFERING RNA; DRUG CARRIER;

ARTICLE; CELL CULTURE; PARTICLE SIZE; PREDICTIVE VALUE; PROCESS OPTIMIZATION; SURFACE PROPERTY; ULTRASOUND; CHEMISTRY; GENE SILENCING; HEK293 CELL LINE; HUMAN; PROCEDURES;

CHITOSAN; DRUG CARRIERS; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; NANOPARTICLES; PARTICLE SIZE; RNA, SMALL INTERFERING; SONICATION;

EID: 84915764341     PISSN: 21593337     EISSN: 21593345     Source Type: Journal    
DOI: 10.1089/nat.2014.0484     Document Type: Article

References (20)

1. Howard KA. (2009). Delivery of RNA interference therapeutics using polycation-based nanoparticles. Adv Drug Deliv Rev 61:710-720.
2. Dodane V and VD Vilivalam. (1998). Pharmaceutical applications of chitosan. Pharm Sci Technolo Today 1:246-253.
3. Yuan X, BA Shah, NK Kotadia, J Li, H Gu and Z Wu. (2010). The development and mechanism studies of cationic chitosan-modified biodegradable PLGA nanoparticles for efficient siRNA drug delivery. Pharm Res 27:1285-1295.
4. Mao S, W Sun and T Kissel. (2010). Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 62:12-27.
5. Tahara K, T Sakai, H Yamamoto, H Takeuchi and Y Kawashima. (2008). Establishing chitosan coated PLGA nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery. Int J Pharm 354:210-216.
6. Katas H and HO Alpar. (2006). Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release 115:216-225.
7. Bodmeier R and P Maincent. Polymeric dispersions as drug carriers. (1998). Marcel Dekker New York.
8. Desai MP, V Labhasetwar, E Walter, RJ Levy and GL Amidon. (1997). The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm Res 14:1568-1573.
9. Naghibzadeh M, A Amani, M Amini, E Esmaeilzadeh, N Mottaghi-Dastjerdi and MA Faramarzi. (2010). An insight into the interactions between-tocopherol and chitosan in ultrasound-prepared nanoparticles. J Nanomater 2010. doi:10. 1155/2010/818717.
10. Esmaeilzadeh-Gharehdaghi E, MA Faramarzi, MA Amini, A Rouholamini Najafabadi, SM Rezayat and A Amani. (2012). Effects of processing parameters on particle size of ultrasound prepared chitosan nanoparticles: An Artificial Neural Networks Study. Pharm Dev Technol 17:638-647.
11. Esmaeilzadeh-Gharehdaghi E, MA Faramarzi, MA Amini, E Moazeni and A Amani. (2014). Processing/formulation parameters determining dispersity of chitosan particles: an ANNs study. J Microencapsul 31:77-85.
12. Box GEP and DW Behnken. (1960). Some new three-level designs for the study of quantitative variables. Technometrics 2:455-475.
13. Sugimoto M, M Morimoto, H Sashiwa, H Saimoto and Y Shigemasa. (1998). Preparation and characterization of water-soluble chitin and chitosan derivatives. Carbohydr Polym 36:49-59.
14. Yoksan R, M Akashi, S Biramontri and S Chirachanchai. (2001). Hydrophobic chain conjugation at hydroxyl group onto-ray irradiated chitosan. Biomacromolecules 2:1038-1044.
15. Felt O, P Buri and R Gurny. (1998). Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm 24:979-993.
16. Tang ESK, M Huang and LY Lim. (2003). Ultrasonication of chitosan and chitosan nanoparticles. Int J Pharm 265(1-2):103-114.
17. Tsai ML, SW Bai and RH Chen. (2008). Cavitation effects versus stretch effects resulted in different size and polydispersity of ionotropic gelation chitosan-sodium tripolyphosphate nanoparticle. Carbohydr Polym 71:448-457.
18. Gazori T, MR Khoshayand, E Azizi, P Yazdizade, A Nomani and I Haririan. (2009). Evaluation of Alginate/Chitosan nanoparticles as antisense delivery vector: formulation, optimization and in vitro characterization. Carbohydr Polym 77:599-606.
19. Chen RH, JR Chang and JS Shyur. (1997). Effects of ultrasonic conditions and storage in acidic solutions on changes in molecular weight and polydispersity of treated chitosan. Carbohydr Res 299:287-294.
20. Liu X, KA Howard, M Dong, Mo Andersen, UL Rahbek, MG Johnsen, OC Hansen, F Besenbacher and J Kjems. (2007). The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials 28:1280-1288.