Influence of human papillomavirus and p16INK4a on treatment outcome of patients with anal cancer

Radiotherapy and Oncology

Volumn 113, Issue 3, 2014, Pages 331-336

  Koerber, Stefan Alexander ^a,b   Schoneweg, Clara ^a,b   Slynko, Alla ^b   Krug, David ^a,b   Haefner, Matthias F ^a,b   Herfarth, Klaus ^a,b   Debus, Juergen ^a,b   Sterzing, Florian ^a,b   Von Knebel Doeberitz, Magnus ^c   Prigge, Elena Sophie ^c   Reuschenbach, Miriam ^c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Anal canal cancer; HPV; Human papillomavirus; p16; Chemo radiation

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; ETOPOSIDE; FLUOROURACIL; MITOMYCIN; VIRUS DNA; TUMOR MARKER;

ADULT; AGED; ANUS CANCER; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED STUDY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN PAPILLOMAVIRUS TYPE 33; HUMAN PAPILLOMAVIRUS TYPE 45; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NONHUMAN; NUCLEIC ACID AMPLIFICATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RADIATION DOSE; RISK FACTOR; SQUAMOUS CELL CARCINOMA; THROMBOCYTOPENIA; TOMOTHERAPY; TREATMENT OUTCOME; VERY ELDERLY; WART VIRUS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; DISEASE FREE SURVIVAL; ISOLATION AND PURIFICATION; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PAPILLOMAVIRIDAE; PATHOLOGY; PROCEDURES; PROGNOSIS; SURVIVAL RATE; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PAPILLOMAVIRIDAE; POLYMERASE CHAIN REACTION; PROGNOSIS; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84915753318     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2014.11.013     Document Type: Article

References (37)

1. L.G. Johnson, M.M. Madeleine, L.M. Newcomer, S.M. Schwartz, and J.R. Dailing Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973-2000 Cancer 101 2004 281 288
2. R. Siegel, J. Ma, Z. Zou, and A. Jemal Cancer statistics, 2014 CA Cancer J Clin 64 2014 9
3. D. Sebag-Montefiore, H.M. Meadows, and D. Cunningham Three cytotoxic drugs combined with pelvic radiation and as maintenance chemotherapy for patients with squamous cell carcinoma of the anus (SCCA): long-term follow-up of a phase II pilot study using 5-fluorouracil, mitomycin C and cisplatin Radiother Oncol 104 2012 155 160
4. T.M. Briere, C.H. Crane, and S. Beddar Reproducibility and genital sparing with a vaginal dilator used for female anal cancer patients Radiother Oncol 104 2012 161 166
5. T. Dasgupta, D. Rothenstein, and J.F. Chou Intensity-modulated radiotherapy vs. conventional radiotherapy in the treatment of anal squamous cell carcinoma: a propensity score analysis Radiother Oncol 107 2013 189 194
6. S.A. Koerber, A. Slynko, and M.F. Haefner Efficacy and toxicity of chemoradiation in patients with anal cancer - a retrospective analysis Radiat Oncol 2014 May 13 10.1186/1748-717X-9-113
7. J.M. Palefsky Anal human papillomavirus infection and anal cancer in HIV-positive individuals: an emerging problem AIDS 8 1994 283
8. H zur Hausen Papillomaviruses and cancer: from basic studies to clinical application Nat Rev Cancer 2 2002 342 350
9. K.K. Ang, J. Harris, and R. Wheeler Human papillomavirus and survival of patients with oropharyngeal cancer N Engl J Med 363 2010 24 35
10. P.M. Weinberger, Z. Yu, and B.G. Haffty Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis J Clin Oncol 24 2006 736 747
11. M. Serrano, G.J. Hannon, and D. Beach A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 Nature 366 1993 704 707
12. J. Koh, G.H. Enders, B.D. Dynlacht, and E. Harlow Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition Nature 375 1995 506 510
13. D. Rischin, R.J. Young, and R. Fisher Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial J Clin Oncol 28 2010 4142 4148
14. R. Klaes, T. Friedrich, and D. Spitkovsky Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri Int J Cancer 92 2001 276 284
15. M. von Knebel Doeberitz, M. Reuschenbach, D. Schmidt, and C. Bergeron Biomarkers for cervical cancer screening: the role of p16(INK4a) to highlight transforming HPV infections Expert Rev Proteomics 9 2012 149 163
16. P. Lassen, J.G. Eriksen, S. Hamilton-Dutoit, T. Tramm, J. Alsner, and J. Overgaard Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck J Clin Oncol 27 2009 1992 1998
17. A.G. Schache, T. Liloglou, and J.M. Risk Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination Clin Cancer Res 17 2011 6262 6271
18. H.Y. Yhim, N.R. Lee, and E.K. Song The prognostic significance of tumor human papillomavirus status for patients with anal squamous cell carcinoma treated with combined chemoradiotherapy Int J Cancer 129 2011 1752 1760
19. E. Serup-Hansen, D. Linnemann, W. Skovrider-Ruminski, E. Høgdall, P.F. Geertsen, and H. Havsteen Human papillomavirus genotyping and p16 expression as prognostic factors for patients with American Joint Committee on cancer stages I-III carcinoma of the anal canal J Clin Oncol 32 2014 1812 1817
20. J.E. Meyer, V.J. Panico, H.M. Marconato, D.L. Sherr, P. Christos, and E.C. Pirog HIV positivity but not HPV/p16 status is associated with higher recurrence rate in anal cancer J Gastrointest Cancer 44 2013 450 455
21. M. Schmitt, I.G. Bravo, P.J. Snijders, L. Gissmann, M. Pawlita, and T. Waterboer Bead-based multiplex genotyping of human papillomaviruses J Clin Microbiol 44 2006 504 512
22. ES Prigge, C Toth, and G Dyckhoff p16INK4a/Ki-67 co-expression specifically identifies transformed cells in the head and neck region Int J Cancer 2014 10.1002/ijc.29130 [Epub ahead of print]
23. R. Klaes, A. Benner, and T. Friedrich P16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia Am J Surg Pathol 26 2002 1389 1399
24. M. Reuschenbach, K. Kansy, and K. Garbe Lack of evidence of human papillomavirus-induced squamous cell carcinomas of the oral cavity in southern Germany Oral Oncol 49 2013 937 942
25. R. Glynne-Jones, P.J. Nilsson, and C. Aschele Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up Radiother Oncol 111 2014 330 339
26. D.C. Gilbert, A. Williams, and K. Allan P16INK4A, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: correlation with outcomes following chemo-radiotherapy Radiother Oncol 109 2013 146 151
27. O. Bruland, O. Fluge, and H. Immervoll Gene expression reveals two distinct groups of anal carcinomas with clinical implications Br J Cancer 98 2008 1264 1273
28. J.A. Ajani, Wang, and J.G. Izzo Molecular biomarkers correlate with disease-free survival in patients with anal canal carcinoma treated with chemoradiation Dig Dis Sci 55 2010 1098 1105
29. M.R. Posner, J.H. Lorch, and O. Goloubeva Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial Ann Oncol 22 2011 1071 1077
30. D. Holzinger, M. Schmitt, and G. Dyckhoff Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement Cancer Res 72 2012 4993 5003
31. R.C. Jordan, M.W. Lingen, and B. Perez-Ordonez Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials Am J Surg Pathol 36 2012 945 954
32. Z. Deng, M. Hasegawa, and K. Aoki A comprehensive evaluation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous cell carcinoma Int J Oncol 45 2014 67 76
33. CR Salazar, N Anayannis, and RV Smith Combined P16 and human papillomavirus testing predicts head and neck cancer survival Int J Cancer 2014 Apr 5 10.1002/ijc.28876 [Epub ahead of print]
34. F Rödel, U Wieland, and I Fraunholz Human papillomavirus DNA load and p16INK4a expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy Int J Cancer 2014 May 16 10.1002/ijc.28979 [Epub ahead of print]
35. F. Perrone, A. Gloghini, B. Cortelazzi, P. Bossi, L. Licitra, and S. Pilotti Isolating p16-positive/HPV-negative oropharyngeal cancer: an effort worth making Am J Surg Pathol 35 2011 774 777
36. M.M. Rietbergen, R.H. Brakenhoff, and E. Bloemena Human papillomavirus detection and comorbidity: critical issues in selection of patients with oropharyngeal cancer for treatment De-escalation trials Ann Oncol 24 2013 2740 2745
37. J.S. Lewis Jr, W.L. Thorstad, R.D. Chernock, B.H. Haughey, J.H. Yip, and Q. Zhang P16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status Am J Surg Pathol 34 2010 1088 1096